(Q34389540)

1 August 2017

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title

PKB/AKT: functional insights from genetic models (English)

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1 August 2017

M P Scheid

1

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PubMed ID

11584303

1 August 2017

J R Woodgett

series ordinal

2

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1 August 2017

1 October 2001

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Nature Reviews Molecular Cell Biology

1 August 2017

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1 August 2017

2

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1 August 2017

760-768

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1 August 2017

10

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https://scigraph.springernature.com/pub.10.1038/35096067

1 August 2017

0 references

cites work

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

7 January 2021

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

7 January 2021

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

1 reference

7 January 2021

Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation.

1 reference

7 January 2021

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

7 January 2021

Role of translocation in the activation and function of protein kinase B

1 reference

7 January 2021

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1 reference

7 January 2021

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

7 January 2021

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

1 reference

7 January 2021

Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473.

1 reference

7 January 2021

Two splice variants of protein kinase B gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site serine 472 in the carboxyl-terminal hydrophobic domain

1 reference

7 January 2021

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

1 reference

7 January 2021

Regulation of protein kinase C.

1 reference

7 January 2021

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

1 reference

7 January 2021

Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase

1 reference

7 January 2021

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

1 reference

7 January 2021

Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

1 reference

7 January 2021

Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism

1 reference

7 January 2021

Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase

1 reference

7 January 2021

AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

1 reference

7 January 2021

Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

1 reference

7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

7 January 2021

Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

1 reference

7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

7 January 2021

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

1 reference

7 January 2021

Direct control of the Forkhead transcription factor AFX by protein kinase B

1 reference

7 January 2021

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

1 reference

7 January 2021

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

1 reference

7 January 2021

Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells

1 reference

7 January 2021

Phosphorylation and regulation of Raf by Akt (protein kinase B)

1 reference

7 January 2021

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

1 reference

7 January 2021

The Akt kinase signals directly to endothelial nitric oxide synthase

1 reference

7 January 2021

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

1 reference

7 January 2021

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1 reference

7 January 2021

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1 reference

7 January 2021

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

1 reference

7 January 2021

Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells

1 reference

7 January 2021

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

7 January 2021

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

7 January 2021

A motif-based profile scanning approach for genome-wide prediction of signaling pathways

1 reference

7 January 2021

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

1 reference

7 January 2021

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

1 reference

7 January 2021

Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

1 reference

7 January 2021

Mammary gland neoplasia: insights from transgenic mouse models

1 reference

7 January 2021

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

1 reference

7 January 2021

Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

7 January 2021

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

7 January 2021

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1 reference

7 January 2021

Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

1 reference

7 January 2021

Expression of Active Protein Kinase B in T Cells Perturbs Both T and B Cell Homeostasis and Promotes Inflammation

1 reference

7 January 2021

Impaired Fas response and autoimmunity in Pten+/- mice

1 reference

7 January 2021

Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

1 reference

7 January 2021

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

1 reference

7 January 2021

Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast

1 reference

7 January 2021

Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast

1 reference

7 January 2021

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

1 reference

7 January 2021

Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf

1 reference

7 January 2021

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

1 reference

7 January 2021

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

1 reference

7 January 2021

Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinasein Vivoat Thr-412 as well as Thr-252

1 reference

7 January 2021

Identification of CISK, a new member of the SGK kinase family that promotes IL-3-dependent survival

1 reference

7 January 2021

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox

1 reference

7 January 2021

The PX domains of p47phox and p40phox bind to lipid products of PI(3)K

1 reference

7 January 2021

Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes.

1 reference

7 January 2021

Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides

1 reference

7 January 2021

Identification of the TCL1 gene involved in T-cell malignancies

1 reference

7 January 2021

The protooncogene TCL1 is an Akt kinase coactivator

1 reference

7 January 2021

Synthesis and function of 3-phosphorylated inositol lipids

1 reference

7 January 2021

5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells

1 reference

7 January 2021

Lipid phosphatases in the immune system

1 reference

7 January 2021

The multiple roles of PTEN in tumor suppression

1 reference

7 January 2021

PIK3CA is implicated as an oncogene in ovarian cancer.

1 reference

7 January 2021

AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

1 reference

7 January 2021

Mutational Analysis of thePTENGene in Endometrial Carcinoma and Hyperplasia

1 reference

7 January 2021

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1 reference

7 January 2021

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

7 January 2021

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

1 reference

7 January 2021

Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway.

1 reference

7 January 2021

Regulation of C. elegans life-span by insulinlike signaling in the nervous system

1 reference

7 January 2021

Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family

1 reference

7 January 2021

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

1 reference

7 January 2021

The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila

1 reference

7 January 2021

Genetic analysis of protein kinase B (AKT) in Drosophila

1 reference

7 January 2021

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.

1 reference

7 January 2021

A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development

1 reference

7 January 2021

RasC is required for optimal activation of adenylyl cyclase and Akt/PKB during aggregation

1 reference

7 January 2021

Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium

1 reference

7 January 2021

Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa

1 reference

7 January 2021

Identifiers

DOI

10.1038/35096067

1 reference

PubMed ID

11584303

Dimensions Publication ID

1 August 2017

0 references

1 reference

PubMed ID

11584303