(Q35214808)

7 August 2017

title

Defining the factors that contribute to on-target specificity of antisense oligonucleotides (English)

1 reference

7 August 2017

Walt F Lima

1

1 reference

7 August 2017

Timothy A Vickers

2

1 reference

7 August 2017

Josh Nichols

3

1 reference

7 August 2017

Cheryl Li

4

1 reference

7 August 2017

Stanley T Crooke

5

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7 August 2017

language of work or name

English

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publication date

29 July 2014

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7 August 2017

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7 August 2017

volume

9

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7 August 2017

issue

7

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7 August 2017

page(s)

e101752

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Creative Commons Attribution 4.0 International

7 August 2017

copyright license

start time

29 July 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Structure Activity Relationships of α-L-LNA Modified Phosphorothioate Gapmer Antisense Oligonucleotides in Animals

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Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing

13 July 2018

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RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform

13 July 2018

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Delivery of bifunctional RNAs that target an intronic repressor and increase SMN levels in an animal model of spinal muscular atrophy

13 July 2018

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Gene silencing by synthetic U1 adaptors

13 July 2018

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Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells

13 July 2018

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Modification of MyD88 mRNA splicing and inhibition of IL-1beta signaling in cell culture and in mice with a 2'-O-methoxyethyl-modified oligonucleotide

13 July 2018

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eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay

13 July 2018

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Determination of the role of the human RNase H1 in the pharmacology of DNA-like antisense drugs

13 July 2018

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Reprogramming Alternative Pre-messenger RNA Splicing through the Use of Protein-binding Antisense Oligonucleotides

13 July 2018

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The human DDX and DHX gene families of putative RNA helicases

13 July 2018

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Bifunctional antisense oligonucleotides provide a trans-acting splicing enhancer that stimulates SMN2 gene expression in patient fibroblasts

13 July 2018

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Human RNase H1 activity is regulated by a unique redox switch formed between adjacent cysteines

13 July 2018

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5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly

13 July 2018

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Downstream sequence elements with different affinities for the hnRNP H/H' protein influence the processing efficiency of mammalian polyadenylation signals

13 July 2018

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Determination of the RNA binding specificity of the heterogeneous nuclear ribonucleoprotein (hnRNP) H/H'/F/2H9 family

13 July 2018

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The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

13 July 2018

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Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm

13 July 2018

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Molecular mechanisms of action of antisense drugs

13 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

Predicting oligonucleotide affinity to nucleic acid targets

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro

13 July 2018

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hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells

13 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

Tetracycline repressor, tetR, rather than the tetR-mammalian cell transcription factor fusion derivatives, regulates inducible gene expression in mammalian cells

13 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

2'-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivo

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

Antisense gene inhibition by oligonucleotides containing C-5 propyne pyrimidines

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

Purification, subunit structure, and serologicai analysis of calf thymus ribonuclease H I

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

Identification of functional U1 snRNA-pre-mRNA complexes committed to spliceosome assembly and splicing

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

Molecular cloning of a ribonuclease H (RNase HI) gene from an extreme thermophileThermus thermophilusHB8: a thermostable RNase H can functionally replace theEscherichia colienzymein vivo

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

Selective cloning of genes encoding RNase H from Salmonella typhimurium, Saccharomyces cerevisiae and Escherichia coli rnh mutant

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

Selective inhibition of mutant Ha-ras mRNA expression by antisense oligonucleotides

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

The spliceosome assembly pathway in mammalian extracts

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

Expression, purification, and characterization of a recombinant ribonuclease H from Thermus thermophilus HB8

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

Implication of RNA structure on antisense oligonucleotide hybridization kinetics

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

Versatile PCR-mediated insertion or deletion mutagenesis

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

Comparison of RiboGreen and 18S rRNA quantitation for normalizing real-time RT-PCR expression analysis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

Correction of disease-associated exon skipping by synthetic exon-specific activators

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-alpha expression

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4114480

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1 reference

12 December 2020

Substrate specificity of human RNase H1 and its role in excision repair of ribose residues misincorporated in DNA

1 reference

12 December 2020

Combinatorial screening and rational optimization for hybridization to folded hepatitis C virus RNA of oligonucleotides with biological antisense activity

1 reference

12 December 2020

On the molecular weight and subunit composition of calf thymus ribonuclease H1

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0101752

Identifiers

DOI

1 reference

7 August 2017

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7 August 2017

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