(Q35220552)

7 August 2017

title

Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans (English)

1 reference

7 August 2017

18

Johan Auwerx

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Patrick Schrauwen

20

Patrick Schrauwen

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Matthijs Hesselink

17

Matthijs K C Hesselink

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Evan G Williams

Evan G Williams

Roshan Samuel Livingstone

4

0 references

7

Roshan Livingstone

1 reference

7 August 2017

19

Michael Roden

1 reference

7 August 2017

9

Lauren M Sparks

1 reference

Vera B. Schrauwen-Hinderling

7 August 2017

16

Vera B Schrauwen-Hinderling

1 reference

7 August 2017

3

Lena Bilet

1 reference

7 August 2017

2

Esther Phielix

1 reference

7 August 2017

1

Tineke van de Weijer

1 reference

7 August 2017

10

Sabina Paglialunga

1 reference

7 August 2017

11

Julia Szendroedi

1 reference

7 August 2017

Eduardo R Ropelle

5

1 reference

7 August 2017

Alessandra Bierwagen

6

1 reference

7 August 2017

Peter Nowotny

8

1 reference

7 August 2017

Bas Havekes

12

1 reference

7 August 2017

Norman Moullan

13

1 reference

7 August 2017

Eija Pirinen

14

1 reference

7 August 2017

Jong-Hee Hwang

15

1 reference

7 August 2017

language of work or name

English

0 references

publication date

28 October 2014

1 reference

7 August 2017

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7 August 2017

volume

64

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7 August 2017

issue

4

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7 August 2017

page(s)

1193-1201

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Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle

7 August 2017

cites work

1 reference

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Reduction of non-esterified fatty acids improves insulin sensitivity and lowers oxidative stress, but fails to restore oxidative capacity in type 2 diabetes: a randomised clinical trial

28 July 2018

1 reference

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The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

28 July 2018

1 reference

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Mitonuclear protein imbalance as a conserved longevity mechanism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

PARP-2 regulates SIRT1 expression and whole-body energy expenditure

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Prolonged fasting identifies skeletal muscle mitochondrial dysfunction as consequence rather than cause of human insulin resistance

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Mitochondrial dysfunction and lipotoxicity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

The gross composition of the body

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Mechanism of free fatty acid-induced insulin resistance in humans

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Different acute and chronic effects of acipimox treatment on glucose and lipid metabolism in patients with type 2 diabetes.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

The dawn phenomenon: its origin and contribution to early morning hyperglycemia in diabetes mellitus

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Nocturnal elevation of glucose levels during fasting in noninsulin-dependent diabetes.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Glucose clamp technique: a method for quantifying insulin secretion and resistance

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Muscle mitochondrial ATP synthesis and glucose transport/phosphorylation in type 2 diabetes

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Peroxisome proliferator-activated receptor-gamma coactivator-1 and insulin resistance: acute effect of fatty acids.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Plasma free Fatty Acid uptake and oxidation are already diminished in subjects at high risk for developing type 2 diabetes

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Lipid-dependent control of hepatic glycogen stores in healthy humans.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Calculation of substrate oxidation rates in vivo from gaseous exchange.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375076

Metabolic consequences of sustained suppression of free fatty acids by acipimox in patients with NIDDM

26 September 2018

1 reference

12 December 2020

Pronounced blood glucose-lowering effect of the antilipolytic drug acipimox in noninsulin-dependent diabetes mellitus patients during a 3-day intensified treatment period

1 reference

12 December 2020

Influences of glucose loading and of injected insulin on hepatic glucose output

1 reference

12 December 2020

Paradoxical changes in muscle gene expression in insulin-resistant subjects after sustained reduction in plasma free fatty acid concentration

1 reference

12 December 2020

Optimisation of oil red O staining permits combination with immunofluorescence and automated quantification of lipids

1 reference

12 December 2020

Diet, Muscle Glycogen and Physical Performance

1 reference

12 December 2020

Variability of aerobic performance in the laboratory and its physiologic correlates

1 reference

12 December 2020

Effects of acipimox on serum lipids, lipoproteins and lipolytic enzymes in hypertriglyceridemia

1 reference

12 December 2020

Reduced triglyceridemia and increased high density lipoprotein cholesterol levels after treatment with acipimox, anew inhibitor of lipolysis

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB14-0667

1 reference

7 August 2017

1 reference

7 August 2017

1 reference