(Q35224081)

25263522

7 August 2017

title

Anti-DKK1 antibody promotes bone fracture healing through activation of β-catenin signaling (English)

1 reference

7 August 2017

1 reference

4

1 reference

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4 June 2020

Peijian Tong

11

1 reference

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4 June 2020

author name string

Hongting Jin

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25263522%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Baoli Wang

2

1 reference

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4 June 2020

Jia Li

3

1 reference

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4 June 2020

Qiang Mao

5

1 reference

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4 June 2020

Shan Li

6

1 reference

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4 June 2020

Fuqiang Dong

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25263522%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Yan Sun

8

1 reference

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4 June 2020

Hua-Zhu Ke

9

1 reference

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4 June 2020

Philip Babij

10

1 reference

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4 June 2020

Di Chen

12

1 reference

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4 June 2020

publication date

28 September 2014

1 reference

7 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25263522%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

volume

71

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4 June 2020

page(s)

63-75

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25263522%20AND%20SRC:MED&resulttype=core&format=json

miR-346 regulates osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by targeting the Wnt/β-catenin pathway

4 June 2020

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Chondrocyte BMP2 signaling plays an essential role in bone fracture healing.

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13 July 2018

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13 July 2018

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Potential role for therapies targeting DKK1, LRP5, and serotonin in the treatment of osteoporosis

13 July 2018

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13 July 2018

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Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury

13 July 2018

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Silencing Dkk1 expression rescues dexamethasone-induced suppression of primary human osteoblast differentiation

13 July 2018

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Targeted overexpression of Dkk1 in osteoblasts reduces bone mass but does not impair the anabolic response to intermittent PTH treatment in mice

13 July 2018

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Sclerostin: a gem from the genome leads to bone-building antibodies

13 July 2018

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Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation

13 July 2018

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Modulation of Wnt signaling influences fracture repair

13 July 2018

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Eight genes are highly associated with BMD variation in postmenopausal Caucasian women

13 July 2018

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Mechanisms of bone repair and regeneration

13 July 2018

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Wnt signaling during fracture repair

13 July 2018

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Parathyroid hormone (PTH)-induced bone gain is blunted in SOST overexpressing and deficient mice

13 July 2018

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Mice expressing GFP and CreER in osteochondro progenitor cells in the periosteum

13 July 2018

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Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone

13 July 2018

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Adipogenesis and WNT signalling

13 July 2018

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Beta-catenin in the race to fracture repair: in it to Wnt.

13 July 2018

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Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing

13 July 2018

1 reference

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Bone mass is inversely proportional to Dkk1 levels in mice

13 July 2018

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Epidemiology of adult fractures: A review

13 July 2018

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The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment

13 July 2018

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Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

13 July 2018

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Wnt signaling activation during bone regeneration and the role of Dishevelled in chondrocyte proliferation and differentiation.

13 July 2018

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Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice

13 July 2018

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Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Developmental regulation of the growth plate

13 July 2018

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Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation.

13 July 2018

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High bone density due to a mutation in LDL-receptor-related protein 5

13 July 2018

1 reference

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Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

13 July 2018

1 reference

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A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376475

13 July 2018

1 reference

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Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376475

Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376475

Does adult fracture repair recapitulate embryonic skeletal formation?

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376475

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376475

SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376475

Rats treated with AZD2858, a GSK3 inhibitor, heal fractures rapidly without endochondral bone formation.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376475

A rate-limiting role for Dickkopf-1 in bone formation and the remediation of bone loss in mouse and primate models of postmenopausal osteoporosis by an experimental therapeutic antibody

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376475

Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376475

Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376475

Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376475

Prevalence of long-bone non-unions.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376475

Bone regeneration is regulated by wnt signaling.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376475

Tbx5 is dispensable for forelimb outgrowth.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376475

Hypomorphic expression of Dkk1 in the doubleridge mouse: dose dependence and compensatory interactions with Lrp6.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376475

Chondrocyte-specific enhancer elements in the Col11a2 gene resemble the Col2a1 tissue-specific enhancer

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376475

Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376475

Models of tibial fracture healing in normal and Nf1-deficient mice

26 September 2018

1 reference

12 December 2020

Transcriptional profiling of bone regeneration. Insight into the molecular complexity of wound repair

1 reference

12 December 2020

The cell and molecular biology of fracture healing

1 reference

12 December 2020

Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass

1 reference

12 December 2020

Dickkopf-1 is a master regulator of joint remodeling

1 reference

12 December 2020

Wnt signaling as a therapeutic target for bone diseases

1 reference

12 December 2020

The role of Dkk1 in bone mass regulation: correlating serum Dkk1 expression with bone mineral density

1 reference

12 December 2020

The effects of Dickkopf-1 antibody on metaphyseal bone and implant fixation under different loading conditions

1 reference

12 December 2020

10.1016/J.BONE.2014.07.039

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25263522%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25263522%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

25263522

1 reference