(Q83588890)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19335070%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

review article

1 reference

title

Wnt signaling as a therapeutic target for bone diseases (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19335070%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

author name string

Luke H Hoeppner

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19335070%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Frank J Secreto

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19335070%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Jennifer J Westendorf

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19335070%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

publication date

1 April 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19335070%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Therapeutic Targets

25 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19335070%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

volume

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19335070%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19335070%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

page(s)

485-496

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19335070%20AND%20SRC:MED&resulttype=core&format=json

A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation

25 January 2020

cites work

1 reference

12 December 2020

Changes in osteoblast, chondrocyte, and adipocyte lineages mediate the bone anabolic actions of PTH and small molecule GSK-3 inhibitor.

1 reference

12 December 2020

Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation

1 reference

12 December 2020

Building bone to reverse osteoporosis and repair fractures

1 reference

12 December 2020

Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin

1 reference

12 December 2020

Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo

1 reference

12 December 2020

Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease

1 reference

12 December 2020

Modulation of Dickkopf-1 attenuates glucocorticoid induction of osteoblast apoptosis, adipocytic differentiation, and bone mass loss

1 reference

12 December 2020

Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

1 reference

12 December 2020

Msx2 exerts bone anabolism via canonical Wnt signaling

1 reference

12 December 2020

Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density

1 reference

12 December 2020

Beta-catenin in the race to fracture repair: in it to Wnt.

1 reference

12 December 2020

Alternative wnt signaling is initiated by distinct receptors.

1 reference

12 December 2020

Bisphosphonates: mechanism of action and role in clinical practice

1 reference

12 December 2020

Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum

1 reference

12 December 2020

Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice.

1 reference

12 December 2020

Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis.

1 reference

12 December 2020

Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate.

1 reference

12 December 2020

Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides

1 reference

12 December 2020

Lithium's effect on bone mineral density

1 reference

12 December 2020

Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma.

1 reference

12 December 2020

Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis

1 reference

12 December 2020

Knocking down dickkopf-1 alleviates estrogen deficiency induction of bone loss. A histomorphological study in ovariectomized rats

1 reference

12 December 2020

The many ways of Wnt in cancer

1 reference

12 December 2020

Dickkopf-1 is a master regulator of joint remodeling

1 reference

12 December 2020

Epidemiology of Osteoporosis

1 reference

12 December 2020

Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo

1 reference

12 December 2020

Secreted frizzled-related protein 1 modulates glucocorticoid attenuation of osteogenic activities and bone mass

1 reference

12 December 2020

1 reference

12 December 2020

Epidemiology of fractures in England and Wales

1 reference

12 December 2020

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

1 reference

12 December 2020

Glycogen synthase kinase-3: properties, functions, and regulation

1 reference

12 December 2020

Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

1 reference

12 December 2020

Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development.

1 reference

12 December 2020

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

1 reference

12 December 2020

High bone density due to a mutation in LDL-receptor-related protein 5

1 reference

12 December 2020

Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

1 reference

12 December 2020

Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone (1-34) for 2 years and relevance to human safety

1 reference

12 December 2020

Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial

1 reference

12 December 2020

The natural history of sclerosteosis

1 reference

12 December 2020

Wnt proteins are lipid-modified and can act as stem cell growth factors

1 reference

12 December 2020

Secreted antagonists of the Wnt signalling pathway

1 reference

12 December 2020

High bone mass in mice expressing a mutant LRP5 gene

1 reference

12 December 2020

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

1 reference

12 December 2020

The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma

1 reference

12 December 2020

Nonunion: general principles and experimental data

1 reference

12 December 2020

Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist

1 reference

12 December 2020

The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice

1 reference

12 December 2020

Bone biomechanical properties in LRP5 mutant mice

1 reference

12 December 2020

Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.

1 reference

12 December 2020

Substituted 3-imidazo[1,2-a]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino-[6,7,1-hi]indol-7-yl)pyrrole-2,5-diones as highly selective and potent inhibitors of glycogen synthase kinase-3.

1 reference

12 December 2020

Wnt signaling in osteoblasts and bone diseases

1 reference

12 December 2020

Mutations affecting segment number and polarity in Drosophila

1 reference

12 December 2020

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

1 reference

12 December 2020

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

1 reference

12 December 2020

Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice

1 reference

12 December 2020

Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

1 reference

12 December 2020

Sequential roles of Hedgehog and Wnt signaling in osteoblast development

1 reference

12 December 2020

Regulation of osteoblastogenesis and bone mass by Wnt10b

1 reference

12 December 2020

The role of Axin2 in calvarial morphogenesis and craniosynostosis

1 reference

12 December 2020

Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals

1 reference

12 December 2020

Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes

1 reference

12 December 2020

Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis

1 reference

12 December 2020

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

1 reference

12 December 2020

Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

1 reference

12 December 2020

Essential role of beta-catenin in postnatal bone acquisition

1 reference

12 December 2020

Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

1 reference

12 December 2020

TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro

1 reference

12 December 2020

Calcified rheumatic valve neoangiogenesis is associated with vascular endothelial growth factor expression and osteoblast-like bone formation

1 reference

12 December 2020

Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease

1 reference

12 December 2020

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

1 reference

12 December 2020

Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation

1 reference

12 December 2020

Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis

1 reference

12 December 2020

Reduced relative risk of fractures among users of lithium

1 reference

12 December 2020

Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice

1 reference

12 December 2020

A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

1 reference

12 December 2020

Lithium: a review of its metabolic adverse effects

1 reference

12 December 2020

Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context

1 reference

12 December 2020

Orally bioavailable GSK-3alpha/beta dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo

1 reference

12 December 2020

Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass

1 reference

12 December 2020

Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors.

1 reference

12 December 2020

Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

1 reference

12 December 2020

Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity

1 reference

12 December 2020

Lithium use and the risk of fractures.

1 reference

12 December 2020

Novel LRP5 missense mutation in a patient with a high bone mass phenotype results in decreased DKK1-mediated inhibition of Wnt signaling

1 reference

12 December 2020

Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease

1 reference

12 December 2020

Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing

1 reference

12 December 2020

Bone mass is inversely proportional to Dkk1 levels in mice

1 reference

12 December 2020

Inhibition of SFRP1 reduces severity of periodontitis

1 reference

12 December 2020

GSK-3beta controls osteogenesis through regulating Runx2 activity

1 reference

12 December 2020

Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women

1 reference

12 December 2020

10.1517/14728220902841961

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19335070%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19335070%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference