(Q35225057)

7 August 2017

title

Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics (English)

1 reference

7 August 2017

1 reference

Leigh A Stoddart

3

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Stephen J Briddon

object named as

Stephen J Briddon

4

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Stephen J. Hill

object named as

Stephen J Hill

5

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author name string

Lauren T May

1

1 reference

7 August 2017

Lloyd J Bridge

2

1 reference

7 August 2017

language of work or name

English

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publication date

29 June 2011

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7 August 2017

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7 August 2017

volume

25

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7 August 2017

issue

10

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7 August 2017

page(s)

3465-3476

1 reference

Allostery at G Protein-Coupled Receptor Homo- and Heteromers: Uncharted Pharmacological Landscapes

7 August 2017

cites work

1 reference

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Class A GPCR heterodimers: evidence from binding studies

27 July 2018

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The effect of allosteric modulators on the kinetics of agonist-G protein-coupled receptor interactions in single living cells

27 July 2018

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Antagonist selective modulation of adenosine A1 and A3 receptor pharmacology by the food dye Brilliant Black BN: evidence for allosteric interactions

27 July 2018

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Progress in elucidating the structural and dynamic character of G Protein-Coupled Receptor oligomers for use in drug discovery

27 July 2018

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Bimolecular fluorescence complementation: lighting up seven transmembrane domain receptor signalling networks

27 July 2018

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The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways.

27 July 2018

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GPCR homomers and heteromers: a better choice as targets for drug development than GPCR monomers?

27 July 2018

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Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation.

27 July 2018

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Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2.

27 July 2018

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G protein-coupled receptor hetero-dimerization: contribution to pharmacology and function

27 July 2018

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Modelling the interdependence between the stoichiometry of receptor oligomerization and ligand binding for a coexisting dimer/tetramer receptor system

27 July 2018

1 reference

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Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

27 July 2018

1 reference

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Translocation of arrestin induced by human A(3) adenosine receptor ligands in an engineered cell line: comparison with G protein-dependent pathways

27 July 2018

1 reference

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Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer

27 July 2018

1 reference

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Agonist-occupied A3 adenosine receptors exist within heterogeneous complexes in membrane microdomains of individual living cells.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177574

Collateral efficacy in drug discovery: taking advantage of the good (allosteric) nature of 7TM receptors

27 July 2018

1 reference

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A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein

27 July 2018

1 reference

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International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers.

27 July 2018

1 reference

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How many drug targets are there?

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177574

Adenosine receptors as therapeutic targets

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177574

Allosterism at muscarinic receptors: ligands and mechanisms

27 July 2018

1 reference

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Principles: a model for the allosteric interactions between ligand binding sites within a dimeric GPCR.

27 July 2018

1 reference

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Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177574

Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177574

Allosteric binding sites on cell-surface receptors: novel targets for drug discovery

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177574

The ligand paradox between affinity and efficacy: can you be there and not make a difference?

27 July 2018

1 reference

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G protein-coupled receptor allosterism and complexing

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177574

Identification by site-directed mutagenesis of residues involved in ligand recognition and activation of the human A3 adenosine receptor

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177574

Oligomerization of G-protein-coupled transmitter receptors.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177574

Cardiac muscarinic receptors. Cooperativity as the basis for multiple states of affinity.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177574

Fingerprinting G-protein-coupled receptors

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177574

Therapeutic potential of β-arrestin- and G protein-biased agonists.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177574

Teaching old receptors new tricks: biasing seven-transmembrane receptors

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177574

Evidence for distinct antagonist-revealed functional states of 5-hydroxytryptamine(2A) receptor homodimers.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177574

Plasma membrane diffusion of G protein-coupled receptor oligomers

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177574

Allosteric properties of G protein-coupled receptor oligomers

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177574

New fluorescent adenosine A1-receptor agonists that allow quantification of ligand-receptor interactions in microdomains of single living cells.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177574

Allosteric Modulation of G Protein–Coupled Receptors

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177574

The two-state dimer receptor model: a general model for receptor dimers

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177574

Dopamine D2 receptor dimer formation: evidence from ligand binding

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177574

Kinetic studies of co-operativity at atrial muscarinic M2 receptors with an "infinite dilution" procedure

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177574

GCRDb: a G-protein-coupled receptor database

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3177574

Influence of receptor number on functional responses elicited by agonists acting at the human adenosine A(1) receptor: evidence for signaling pathway-dependent changes in agonist potency and relative intrinsic activity

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21715680

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cooperativity Manifest in the Binding Properties of Purified Cardiac Muscarinic Receptors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21715680

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Dimer-based model for heptaspanning membrane receptors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21715680

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1096/FJ.11-186296

1 reference

7 August 2017

1 reference

7 August 2017

1 reference