(Q35246304)

7 August 2017

title

Molecular mapping of general anesthetic sites in a voltage-gated ion channel (English)

1 reference

7 August 2017

4

Werner Treptow

1 reference

7 August 2017

Annika F Barber

1

1 reference

7 August 2017

Qiansheng Liang

series ordinal

2

1 reference

7 August 2017

Cristiano Amaral

series ordinal

3

1 reference

7 August 2017

Manuel Covarrubias

series ordinal

5

1 reference

7 August 2017

language of work or name

English

0 references

publication date

1 October 2011

1 reference

7 August 2017

1 reference

7 August 2017

volume

101

1 reference

7 August 2017

issue

7

1 reference

7 August 2017

page(s)

1613-1622

1 reference

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

7 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Ion channel voltage sensors: structure, function, and pathophysiology

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Azi-isoflurane, a Photolabel Analog of the Commonly Used Inhaled General Anesthetic Isoflurane

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Modulation of KvAP unitary conductance and gating by 1-alkanols and other surface active agents

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Inhalational anaesthetics and n-alcohols share a site of action in the neuronal Shaw2 Kv channel

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

A Unitary Anesthetic Binding Site at High Resolution

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

The site of anesthetic action

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Dynamics of the Kv1.2 voltage-gated K+ channel in a membrane environment

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Isoflurane inhibits NaChBac, a prokaryotic voltage-gated sodium channel

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Reversal of HCN channel voltage dependence via bridging of the S4-S5 linker and Post-S6.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Environment of the gating charges in the Kv1.2 Shaker potassium channel

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Emerging molecular mechanisms of general anesthetic action.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

HCN subunit-specific and cAMP-modulated effects of anesthetics on neuronal pacemaker currents.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Molecular Features of an Alcohol Binding Site in a Neuronal Potassium Channel

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Coupling between voltage sensors and activation gate in voltage-gated K+ channels

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Interaction of volatile anesthetics with human Kv channels in relation to clinical concentrations

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

The S4-S5 linker couples voltage sensing and activation of pacemaker channels.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Single-channel basis for conductance increase induced by isoflurane in Shaker H4 IR K(+) channels

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

General anesthetic action at an internal protein site involving the S4-S5 cytoplasmic loop of a neuronal K(+) channel

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Simulations of ion permeation through a potassium channel: molecular dynamics of KcsA in a phospholipid bilayer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Gating kinetics of Shaker K+ channels are differentially modified by general anesthetics.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Uncharged S4 residues and cooperativity in voltage-dependent potassium channel activation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Molecular interactions between inhaled anesthetics and proteins.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Ethanol selectively blocks a noninactivating K+ current expressed in Xenopus oocytes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Halothane inhibits two components of calcium current in clonal (GH3) pituitary cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

n-Alcohols inhibit voltage-gated Na+ channels expressed in Xenopus oocytes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Isoform-selective effects of isoflurane on voltage-gated Na+ channels

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Voltage sensor of Kv1.2: structural basis of electromechanical coupling

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

The protein structure prediction problem could be solved using the current PDB library

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Constitutive activation of the Shaker Kv channel

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Allosteric modulation of a neuronal K+ channel by 1-alkanols is linked to a key residue in the activation gate

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Kinetic modulation of HERG potassium channels by the volatile anesthetic halothane

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Inhibition of presynaptic sodium channels by halothane

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Alcohols inhibit a cloned potassium channel at a discrete saturable site. Insights into the molecular basis of general anesthesia.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183804

Gated access to the pore of a voltage-dependent K+ channel

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21961587

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The concerted contribution of the S4-S5 linker and the S6 segment to the modulation of a Kv channel by 1-alkanols

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21961587

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BPJ.2011.08.026

1 reference

7 August 2017

1 reference

7 August 2017

1 reference