(Q35264283)

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Adaptive Upregulation of EGFR Limits Attenuation of Tumor Growth by Neutralizing IL6 Antibodies, with Implications for Combined Therapy in Ovarian Cancer

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scholarly article

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Europe PubMed Central

7 August 2017

Adaptive Upregulation of EGFR Limits Attenuation of Tumor Growth by Neutralizing IL6 Antibodies, with Implications for Combined Therapy in Ovarian Cancer (English)

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Europe PubMed Central

7 August 2017

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9

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2 June 2020

11

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2 June 2020

Daniel Hochhauser

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Daniel Hochhauser

10

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ORCID Public Data File 2021

5

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Hagen Kulbe

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2 June 2020

Carla S Milagre

1

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Carla S Milagre

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2 June 2020

Gemma L A Everitt

3

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Gemma Everitt

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2 June 2020

Ganga Gopinathan

2

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Ganga Gopinathan

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2 June 2020

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Richard G Thompson

4

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2 June 2020

Haihong Zhong

6

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2 June 2020

Robert E Hollingsworth

7

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2 June 2020

Richard Grose

8

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2 June 2020

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10 February 2015

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7 August 2017

Cancer Research

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2 June 2020

75

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2 June 2020

1255-1264

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2 June 2020

7

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2 June 2020

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4384986/fullTextXML

based on heuristic

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Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.

1 reference

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12 July 2018

IL-6 and related cytokines as the critical lynchpins between inflammation and cancer

1 reference

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Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models

1 reference

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Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells

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12 July 2018

Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling

1 reference

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12 July 2018

STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor

1 reference

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Evaluating cell lines as tumour models by comparison of genomic profiles

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Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling

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The changing view of high-grade serous ovarian cancer

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12 July 2018

Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2.

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Paraneoplastic thrombocytosis in ovarian cancer.

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12 July 2018

Blocking epidermal growth factor receptor activation by 3,3'-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo

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12 July 2018

Ligand-dependent EGFR activation induces the co-expression of IL-6 and PAI-1 via the NFkB pathway in advanced-stage epithelial ovarian cancer

1 reference

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12 July 2018

The nuclear epidermal growth factor receptor signaling network and its role in cancer

1 reference

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A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment

1 reference

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Rethinking ovarian cancer: recommendations for improving outcomes

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12 July 2018

Interleukin-6 as a therapeutic target in human ovarian cancer

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STAT3 inhibition is a therapeutic strategy for ABC-like diffuse large B-cell lymphoma

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Erlotinib or gefitinib for the treatment of relapsed platinum pretreated non-small cell lung cancer and ovarian cancer: a systematic review.

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12 July 2018

The therapeutic potential of targeting the EGFR family in epithelial ovarian cancer

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12 July 2018

IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer

1 reference

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Nuclear EGFR contributes to acquired resistance to cetuximab

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Quantifying Western blots: pitfalls of densitometry.

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12 July 2018

Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer

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Epidermal growth factor-induced ovarian carcinoma cell migration is associated with JAK2/STAT3 signals and changes in the abundance and localization of alpha6beta1 integrin.

1 reference

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12 July 2018

Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas

1 reference

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12 July 2018

The inflammatory cytokine tumor necrosis factor-alpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cells

1 reference

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12 July 2018

Signaling via ErbB2 and ErbB3 associates with resistance and epidermal growth factor receptor (EGFR) amplification with sensitivity to EGFR inhibitor gefitinib in head and neck squamous cell carcinoma cells

1 reference

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12 July 2018

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12 July 2018

The inflammatory cytokine tumor necrosis factor-alpha regulates chemokine receptor expression on ovarian cancer cells

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12 July 2018

Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival

1 reference

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1 reference

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based on heuristic

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1 reference

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1 reference

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based on heuristic

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10.1158/0008-5472.CAN-14-1801

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Europe PubMed Central

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2 June 2020

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2 June 2020

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2 June 2020

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