(Q35281575)

7 August 2017

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title

Androgen receptor gene polymorphisms and alterations in prostate cancer: of humanized mice and men. (English)

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7 August 2017

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1

Diane M Robins

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7 August 2017

publication date

12 June 2011

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Molecular and Cellular Endocrinology

7 August 2017

published in

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7 August 2017

volume

352

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7 August 2017

issue

1-2

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7 August 2017

page(s)

26-33

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Small molecule inhibitors targeting the "achilles' heel" of androgen receptor activity

7 August 2017

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Copy number and targeted mutational analysis reveals novel somatic events in metastatic prostate tumors

27 July 2018

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27 July 2018

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Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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Comparative analyses of chromosome alterations in soft-tissue metastases within and across patients with castration-resistant prostate cancer

27 July 2018

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27 July 2018

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Treatment-dependent androgen receptor mutations in prostate cancer exploit multiple mechanisms to evade therapy

27 July 2018

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Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer

27 July 2018

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Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer

27 July 2018

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Profiling human androgen receptor mutations reveals treatment effects in a mouse model of prostate cancer

27 July 2018

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Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance

27 July 2018

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Comparative lesion sequencing provides insights into tumor evolution

27 July 2018

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27 July 2018

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Male infertility and variation in CAG repeat length in the androgen receptor gene: a meta-analysis

27 July 2018

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Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer

27 July 2018

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A splicing variant of the androgen receptor detected in a metastatic prostate cancer exhibits exclusively cytoplasmic actions.

27 July 2018

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Transcriptional activity of androgen receptor is modulated by two RNA splicing factors, PSF and p54nrb.

27 July 2018

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Loss of androgen receptor binding to selective androgen response elements causes a reproductive phenotype in a knockin mouse model

27 July 2018

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Patterns of somatic mutation in human cancer genomes

27 July 2018

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Human cancers express a mutator phenotype

27 July 2018

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Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis

27 July 2018

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Somatic mosaicism and cancer: a micro-genetic examination into the role of the androgen receptor gene in prostate cancer.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

Mutation of the androgen receptor causes oncogenic transformation of the prostate

27 July 2018

1 reference

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X-chromosome inactivation patterns and androgen receptor functionality influence phenotype and social characteristics as well as pharmacogenetics of testosterone therapy in Klinefelter patients

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

Recognition and accommodation at the androgen receptor coactivator binding interface

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

Multiple mechanisms of male-specific gene expression: lessons from the mouse sex-limited protein (Slp) gene

27 July 2018

1 reference

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Structural and functional consequences of glutamine tract variation in the androgen receptor.

27 July 2018

1 reference

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An androgen receptor NH2-terminal conserved motif interacts with the COOH terminus of the Hsp70-interacting protein (CHIP)

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

Is the Achilles' heel for prostate cancer therapy a gain of function in androgen receptor signaling?

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

The development of androgen-independent prostate cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

Hormone status selects for spontaneous somatic androgen receptor variants that demonstrate specific ligand and cofactor dependent activities in autochthonous prostate cancer.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

Inhibition of p160-mediated coactivation with increasing androgen receptor polyglutamine length

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

Functional characterization of mutant androgen receptors from androgen-independent prostate cancer.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

Molecular analysis of the androgen-receptor gene in a family with receptor-positive partial androgen insensitivity: an unusual type of intronic mutation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

The CAG repeat within the androgen receptor gene and its relationship to prostate cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

Intragenic rearrangement and altered RNA splicing of the androgen receptor in a cell-based model of prostate cancer progression

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

Diverse somatic mutation patterns and pathway alterations in human cancers

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

Integrative genomic profiling of human prostate cancer

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

Increased estrogen rather than decreased androgen action is associated with longer androgen receptor CAG repeats

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

The androgen receptor's CAG/glutamine tract in mouse models of neurological disease and cancer.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

Glutamine tract length of human androgen receptors affects hormone-dependent and -independent prostate cancer in mice

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

The androgen receptor: unlocking the secrets of its unique transactivation domain

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

Mechanistic relationship between androgen receptor polyglutamine tract truncation and androgen-dependent transcriptional hyperactivity in prostate cancer cells

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

Coordinate regulation of transcription and splicing by steroid receptor coregulators

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

Androgen receptor mutations in prostate cancer.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

The CAG and GGC microsatellites of the androgen receptor gene are in linkage disequilibrium in men with prostate cancer.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

High-throughput oncogene mutation profiling in human cancer

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3188356

Selective role of an NH2-terminal WxxLF motif for aberrant androgen receptor activation in androgen depletion independent prostate cancer cells

15 November 2018

1 reference

12 December 2020

1 reference

12 December 2020

Reduced transcriptional regulatory competence of the androgen receptor in X-linked spinal and bulbar muscular atrophy

1 reference

12 December 2020

Microsatellite mutation (CAG24-->18) in the androgen receptor gene in human prostate cancer

1 reference

12 December 2020

Re: Prostate cancer and the androgen receptor

1 reference

12 December 2020

Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk

1 reference

12 December 2020

Replacing the Mouse Androgen Receptor with Human Alleles Demonstrates Glutamine Tract Length-Dependent Effects on Physiology and Tumorigenesis in Mice

1 reference

12 December 2020

Germ-Line Genetic Variation in the Key Androgen-Regulating Genes Androgen Receptor, Cytochrome P450, and Steroid-5- -Reductase Type 2 Is Important for Prostate Cancer Development

1 reference

12 December 2020

10.1016/J.MCE.2011.06.003

Identifiers

DOI

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7 August 2017

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7 August 2017

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