(Q35317995)

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Activation of mitogen-activated protein kinases by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) plays an important role in macrophage stimulation

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Europe PubMed Central

PubMed publication ID

7 August 2017

Activation of mitogen-activated protein kinases by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) plays an important role in macrophage stimulation (English)

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

1 reference

based on heuristic

inferred from title

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ChEBI release 2020-05-28

author name string

Jing Sun

1

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Liang-Chuan S Wang

2

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Zvi G Fridlender

3

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Veena Kapoor

4

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Guanjun Cheng

5

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Lai-Ming Ching

6

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Europe PubMed Central

PubMed publication ID

7 August 2017

Steven M Albelda

7

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Europe PubMed Central

PubMed publication ID

7 August 2017

language of work or name

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publication date

26 July 2011

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Europe PubMed Central

PubMed publication ID

7 August 2017

Biochemical Pharmacology

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Europe PubMed Central

PubMed publication ID

7 August 2017

82

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Europe PubMed Central

PubMed publication ID

7 August 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

1175-1185

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Activation of the nucleotide oligomerization domain signaling pathway by the non-bacterially derived xanthone drug 5'6-dimethylxanthenone-4-acetic acid (Vadimezan).

1 reference

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12 July 2018

Phase II study of ASA404 (vadimezan, 5,6-dimethylxanthenone-4-acetic acid/DMXAA) 1800mg/m(2) combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer

1 reference

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12 July 2018

Glycogen synthase kinase-3 promotes the synergistic action of interferon-gamma on lipopolysaccharide-induced IL-6 production in RAW264.7 cells

1 reference

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12 July 2018

Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer

1 reference

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Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1

1 reference

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12 July 2018

MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages

1 reference

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Interferon alpha induces nucleus-independent apoptosis by activating extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase downstream of phosphatidylinositol 3-kinase and mammalian target of rapamycin

1 reference

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The vascular disrupting agent, DMXAA, directly activates dendritic cells through a MyD88-independent mechanism and generates antitumor cytotoxic T lymphocytes

1 reference

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12 July 2018

The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis

1 reference

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12 July 2018

Short-term treatment of RAW264.7 macrophages with adiponectin increases tumor necrosis factor-alpha (TNF-alpha) expression via ERK1/2 activation and Egr-1 expression: role of TNF-alpha in adiponectin-stimulated interleukin-10 production

1 reference

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12 July 2018

Novel strategies for inhibition of the p38 MAPK pathway.

1 reference

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Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide

1 reference

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12 July 2018

Evidence for the involvement of p38 MAP kinase in the action of the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA).

1 reference

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12 July 2018

Role of MAPKs in development and differentiation: lessons from knockout mice.

1 reference

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12 July 2018

The many paths to p38 mitogen-activated protein kinase activation in the immune system

1 reference

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12 July 2018

Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity

1 reference

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12 July 2018

Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element

1 reference

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12 July 2018

Posttranscriptional regulation of TNFalpha expression via eukaryotic initiation factor 4E (eIF4E) phosphorylation in mouse macrophages

1 reference

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Kaposi's sarcoma-associated herpesvirus induction of AP-1 and interleukin 6 during primary infection mediated by multiple mitogen-activated protein kinase pathways

1 reference

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Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex

1 reference

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12 July 2018

BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo.

1 reference

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12 July 2018

The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation.

1 reference

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An efficient proteomics method to identify the cellular targets of protein kinase inhibitors.

1 reference

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12 July 2018

p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191304

12 July 2018

Clinical aspects of a phase I trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent

1 reference

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Gamma interferon augments the intracellular pathway for lipopolysaccharide (LPS) recognition in human intestinal epithelial cells through coordinated up-regulation of LPS uptake and expression of the intracellular Toll-like receptor 4-MD-2 complex

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12 July 2018

5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: phase I clinical and pharmacokinetic study

1 reference

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Signalling events involved in interferon-gamma-inducible macrophage nitric oxide generation

1 reference

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Is MK2 (mitogen-activated protein kinase-activated protein kinase 2) the key for understanding post-transcriptional regulation of gene expression?

1 reference

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Lipopolysaccharide stimulation of ERK1/2 increases TNF-alpha production via Egr-1.

1 reference

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12 July 2018

MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels

1 reference

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12 July 2018

Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38.

1 reference

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TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

1 reference

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The p38 signal transduction pathway: activation and function

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Activation of the p38 mitogen-activated protein kinase by type I interferons

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Induction of STAT and NFkappaB activation by the antitumor agents 5,6-dimethylxanthenone-4-acetic acid and flavone acetic acid in a murine macrophage cell line

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MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

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Identifiers

10.1016/J.BCP.2011.07.086

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

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