(Q35390305)

8 August 2017

title

Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia (English)

1 reference

8 August 2017

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Korrapati V Sathyasaikumar

1

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8 August 2017

Erin K Stachowski

2

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8 August 2017

Ikwunga Wonodi

3

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8 August 2017

Rosalinda C Roberts

4

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8 August 2017

Arash Rassoulpour

5

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8 August 2017

Robert P McMahon

6

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8 August 2017

Robert Schwarcz

7

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8 August 2017

language of work or name

English

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publication date

29 October 2010

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8 August 2017

published in

Schizophrenia Bulletin

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8 August 2017

volume

37

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8 August 2017

issue

6

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8 August 2017

page(s)

1147-1156

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Increased levels of kynurenine and kynurenic acid in the CSF of patients with schizophrenia.

8 August 2017

cites work

1 reference

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Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behavior

12 July 2018

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Cortical kynurenine pathway metabolism: a novel target for cognitive enhancement in Schizophrenia

12 July 2018

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12 July 2018

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The astrocyte-derived alpha7 nicotinic receptor antagonist kynurenic acid controls extracellular glutamate levels in the prefrontal cortex

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Astrocyte-derived kynurenic acid modulates basal and evoked cortical acetylcholine release

12 July 2018

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Cell and receptor type-specific alterations in markers of GABA neurotransmission in the prefrontal cortex of subjects with schizophrenia

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Characterization of the kynurenine pathway in human neurons

12 July 2018

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Dysfunctional and compensatory prefrontal cortical systems, genes and the pathogenesis of schizophrenia

12 July 2018

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12 July 2018

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12 July 2018

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Calprotectin in microglia from frontal cortex is up-regulated in schizophrenia: evidence for an inflammatory process?

12 July 2018

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Schizophrenia as an inflammation-mediated dysbalance of glutamatergic neurotransmission

12 July 2018

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Cognitive dysfunction in schizophrenia: convergence of gamma-aminobutyric acid and glutamate alterations

12 July 2018

1 reference

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Elevations of endogenous kynurenic acid produce spatial working memory deficits

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

Glutamate and schizophrenia: beyond the dopamine hypothesis

12 July 2018

1 reference

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Association study between kynurenine 3-monooxygenase gene and schizophrenia in the Japanese population.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

Cortical cholinergic transmission and cortical information processing in schizophrenia

12 July 2018

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Potential noradrenergic targets for cognitive enhancement in schizophrenia

12 July 2018

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12 July 2018

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Nicotinic agonists and psychosis

12 July 2018

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Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

Increased cortical kynurenate content in schizophrenia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

Common regions of the human frontal lobe recruited by diverse cognitive demands

12 July 2018

1 reference

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Effects of oxygen on 3-hydroxyanthranilate oxidase of the kynurenine pathway

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

Characterization of rat brain kynurenine aminotransferases I and II.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

Hydrogen peroxide-mediated neuronal cell death induced by an endogenous neurotoxin, 3-hydroxykynurenine

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

Quinolinic acid phosphoribosyltransferase in human and rat brain: activity in Huntington's disease and in quinolinate-lesioned rat striatum

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

Synthesis of quinolinic acid by 3-hydroxyanthranilic acid oxygenase in rat brain tissue in vitro

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

A glycine site associated with N-methyl-D-aspartic acid receptors: characterization and identification of a new class of antagonists

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

Quinolinic acid is a potent lipid peroxidant in rat brain homogenates

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

Cortical kynurenic acid bi-directionally modulates prefrontal glutamate levels as assessed by microdialysis and rapid electrochemistry

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

L-kynurenine treatment alters contextual fear conditioning and context discrimination but not cue-specific fear conditioning.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

Microglia activation in recent-onset schizophrenia: a quantitative (R)-[11C]PK11195 positron emission tomography study.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

Alterations in kynurenine precursor and product levels in schizophrenia and bipolar disorder

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

Prefrontal serotonin depletion affects reversal learning but not attentional set shifting.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

Increased expression of the astrocytic glutamate transporter GLT-1 in the prefrontal cortex of schizophrenics

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

Endogenous kynurenic acid disrupts prepulse inhibition

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

IDO (indolamine 2,3-dioxygenase) expression and function in the CNS.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

Expression of the kynurenine pathway enzyme tryptophan 2,3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

Micromolar Brain Levels of Kynurenic Acid are Associated with a Disruption of Auditory Sensory Gating in the Rat

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

Characterization of human brain kynurenine aminotransferases using [3H]kynurenine as a substrate

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3196941

3-Hydroxykynurenine and 3-Hydroxyanthranilic Acid Generate Hydrogen Peroxide and Promote α-Crystallin Cross-Linking by Metal Ion Reduction†

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FSCHBUL%2FSBQ112

Oxidative reactivity of the tryptophan metabolites 3-hydroxyanthranilate, cinnabarinate, quinolinate and picolinate

21 January 2018

1 reference

12 December 2020

Quantification of 3-hydroxykynurenine in brain by high-performance liquid chromatography and electrochemical detection

1 reference

12 December 2020

Beef liver 3-hydroxyanthranilic acid oxidase

1 reference

12 December 2020

Degeneration of microglial cells in frontal and temporal lobes of chronic schizophrenics

1 reference

12 December 2020

S100B-immunopositive glia is elevated in paranoid as compared to residual schizophrenia: a morphometric study

1 reference

12 December 2020

Indole-3-pyruvic and -propionic acids, kynurenic acid, and related metabolites as luminophores and free-radical scavengers

1 reference

12 December 2020

Radical scavenging properties of tryptophan metabolites. Estimation of their radical reactivity

1 reference

12 December 2020

Increase in HLA-DR immunoreactive microglia in frontal and temporal cortex of chronic schizophrenics

1 reference

12 December 2020

Identifiers

DOI

10.1093/SCHBUL/SBQ112

1 reference

8 August 2017

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8 August 2017

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