(Q35399015)

25375241

8 August 2017

title

A functional approach reveals a genetic and physical interaction between ribonucleotide reductase and CHK1 in mammalian cells (English)

1 reference

8 August 2017

2

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8 June 2020

author name string

Lorena Taricani

1

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8 June 2020

Maria-Christina Malinao

3

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8 June 2020

Maribel Beaumont

4

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8 June 2020

David Parry

5

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8 June 2020

language of work or name

English

0 references

publication date

6 November 2014

1 reference

8 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25375241%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

volume

9

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8 June 2020

issue

11

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8 June 2020

page(s)

e111714

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Creative Commons Attribution 4.0 International

8 June 2020

copyright license

start time

6 November 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

The interaction between checkpoint kinase 1 (Chk1) and the minichromosome maintenance (MCM) complex is required for DNA damage-induced Chk1 phosphorylation

1 reference

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DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response

27 July 2018

1 reference

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Targeting ribonucleotide reductase for cancer therapy.

27 July 2018

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A kinome screen identifies checkpoint kinase 1 (CHK1) as a sensitizer for RRM1-dependent gemcitabine efficacy

27 July 2018

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Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening

27 July 2018

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Features of potentially predictive biomarkers of chemotherapeutic efficacy in small cell lung cancer

27 July 2018

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DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress

27 July 2018

1 reference

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Chk1 regulates the density of active replication origins during the vertebrate S phase.

27 July 2018

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H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation

27 July 2018

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Ribonucleotide reductase inhibitors and future drug design

27 July 2018

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Ribonucleotide reductases

27 July 2018

1 reference

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Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase

27 July 2018

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Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

27 July 2018

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Biochemical modulation of cytarabine triphosphate by clofarabine.

27 July 2018

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Chk1-dependent S-M checkpoint delay in vertebrate cells is linked to maintenance of viable replication structures.

27 July 2018

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Chk1 is essential for tumor cell viability following activation of the replication checkpoint

27 July 2018

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ATM is required for the cellular response to thymidine induced replication fork stress.

27 July 2018

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Mechanisms of apoptosis induction by nucleoside analogs.

27 July 2018

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Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

27 July 2018

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Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells

27 July 2018

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The DNA replication checkpoint response stabilizes stalled replication forks

27 July 2018

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ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

27 July 2018

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Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

27 July 2018

1 reference

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A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

27 July 2018

1 reference

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222937

The enzyme ribonucleotide reductase: target for antitumor and anti-HIV therapy

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222937

Deoxynucleotide pool depletion and sustained inhibition of ribonucleotide reductase and DNA synthesis after treatment of human lymphoblastoid cells with 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine

27 July 2018

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Difluorodeoxyguanosine: cytotoxicity, metabolism, and actions on DNA synthesis in human leukemia cells

27 July 2018

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Localization of ribonucleotide reductase in mammalian cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222937

Subunit M2 of mammalian ribonucleotide reductase. Characterization of a homogeneous protein isolated from M2-overproducing mouse cells.

27 July 2018

1 reference

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Ribonucleotide reductase inhibitors as anticancer and antiviral agents

27 July 2018

1 reference

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Interactions between deoxyribonucleotide and DNA synthesis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222937

EPR stopped-flow studies of the reaction of the tyrosyl radical of protein R2 from ribonucleotide reductase with hydroxyurea

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222937

Reduction of Ribonucleotides

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222937

Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase

27 July 2018

1 reference

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Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0111714

Replication stress activates DNA polymerase alpha-associated Chk1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0111714

The identification of novel 5'-amino gemcitabine analogs as potent RRM1 inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0111714

Ribonucleotide reductase inhibitors: new strategies for cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0111714

Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0111714

Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0111714

Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222937

Dephosphorylation of histone gamma-H2AX during repair of DNA double-strand breaks in mammalian cells and its inhibition by calyculin A.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222937

Interaction of arabinosyl nucleotides in K562 human leukemia cells

26 September 2018

1 reference

12 December 2020

Reduction and loss of the iron center in the reaction of the small subunit of mouse ribonucleotide reductase with hydroxyurea

1 reference

12 December 2020

Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolism

1 reference

12 December 2020

Regulation of ribonucleotide reductase activity in mammalian cells

1 reference

12 December 2020

Simultaneous determination of deoxyribonucleoside in the presence of ribonucleoside triphosphates in human carcinoma cells by high-performance liquid chromatography

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0111714

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25375241%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

0 references

1 reference

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8 June 2020

25375241

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25375241%20AND%20SRC:MED&resulttype=core&format=json