(Q35454522)

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Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.

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scholarly article

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5 February 2020

Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening (English)

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5 February 2020

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5 February 2020

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5 February 2020

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5 February 2020

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5 February 2020

Roger J. Summers

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5 February 2020

Arthur Christopoulos

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5 February 2020

Patrick M. Sexton

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5 February 2020

Laurence J Miller

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Laurence J Miller

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5 February 2020

Cassandra Koole

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Cassandra Koole

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5 February 2020

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Rohan Sridhar

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5 February 2020

publication date

14 June 2010

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5 February 2020

Molecular Pharmacology

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5 February 2020

78

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5 February 2020

3

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5 February 2020

456-465

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5 February 2020

Structural determinants of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor: identification of ligand-specific and global activation mechanisms.

1 reference

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Diabetes medications and body weight

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Functional selectivity in GPCR modulator screening

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Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology.

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Biology of incretins: GLP-1 and GIP

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12 July 2018

Small-molecule agonists for the glucagon-like peptide 1 receptor

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Oxyntomodulin : a novel potential treatment for obesity

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Functional Selectivity and Classical Concepts of Quantitative Pharmacology

1 reference

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12 July 2018

Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Galpha(s) and Galpha(i)/Galpha(o) activation.

1 reference

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12 July 2018

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12 July 2018

Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.

1 reference

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12 July 2018

Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo

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Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line

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26 September 2018

The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances beta-cell function but does not inhibit gastric emptying in mice

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based on heuristic

inferred from PubMed ID database lookup

Both Subcutaneously and Intravenously Administered Glucagon-Like Peptide I Are Rapidly Degraded From the NH2-Terminus in Type II Diabetic Patients and in Healthy Subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/20547734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic roles of the M3 muscarinic acetylcholine receptor studied with M3 receptor mutant mice: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/20547734

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/MOL.110.065664

1 reference

Europe PubMed Central

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5 February 2020

1 reference

Europe PubMed Central

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5 February 2020

1 reference

Europe PubMed Central

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5 February 2020

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