(Q35475256)

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The expression of the endoplasmic reticulum stress sensor BiP/GRP78 predicts response to chemotherapy and determines the efficacy of proteasome inhibitors in diffuse large b-cell lymphoma

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21907693%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

The expression of the endoplasmic reticulum stress sensor BiP/GRP78 predicts response to chemotherapy and determines the efficacy of proteasome inhibitors in diffuse large b-cell lymphoma (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21907693%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

endoplasmic reticulum

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B-cell lymphoma

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diffuse large B-cell lymphoma

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1

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12 February 2020

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12 February 2020

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12 February 2020

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12 February 2020

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12 February 2020

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Armando López-Guillermo

3

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12 February 2020

Antonio Martinez

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12 February 2020

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9 September 2011

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12 February 2020

The American Journal of Pathology

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12 February 2020

179

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12 February 2020

5

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12 February 2020

2601-2610

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Europe PubMed Central

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12 February 2020

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3204085/fullTextXML

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1 reference

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Aggressive lymphomas

1 reference

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Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP

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Blockade of GRP78 sensitizes breast cancer cells to microtubules-interfering agents that induce the unfolded protein response.

1 reference

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12 July 2018

Phase I trial of fludarabine, bortezomib and rituximab for relapsed and refractory indolent and mantle cell non-Hodgkin lymphoma

1 reference

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12 July 2018

Dysregulation of unfolded protein response partially underlies proapoptotic activity of bortezomib in multiple myeloma cells

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Activation of the endoplasmic reticulum stress-associated transcription factor x box-binding protein-1 occurs in a subset of normal germinal-center B cells and in aggressive B-cell lymphomas with prognostic implications

1 reference

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12 July 2018

Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphoma

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1 reference

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Down-regulation of GRP78 is associated with the sensitivity of chemotherapy to VP-16 in small cell lung cancer NCI-H446 cells

1 reference

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12 July 2018

Bortezomib in patients with relapsed or refractory mantle cell lymphoma: updated time-to-event analyses of the multicenter phase 2 PINNACLE study

1 reference

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Stromal gene signatures in large-B-cell lymphomas

1 reference

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Updated survival analyses after prolonged follow-up of the phase 2, multicenter CREST study of bortezomib in relapsed or refractory multiple myeloma

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The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells

1 reference

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Noxa mediates bortezomib induced apoptosis in both sensitive and intrinsically resistant mantle cell lymphoma cells and this effect is independent of constitutive activity of the AKT and NF-kappaB pathways

1 reference

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12 July 2018

GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth

1 reference

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12 July 2018

The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.

1 reference

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12 July 2018

Different induction of GRP78 and CHOP as a predictor of sensitivity to proteasome inhibitors in thyroid cancer cells

1 reference

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12 July 2018

The proteasome inhibitor bortezomib acts independently of p53 and induces cell death via apoptosis and mitotic catastrophe in B-cell lymphoma cell lines

1 reference

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Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer

1 reference

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Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphoma

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma

1 reference

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The addition of bryostatin 1 to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy improves response in a CHOP-resistant human diffuse large cell lymphoma xenograft model.

1 reference

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1 reference

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Prevalence of bortezomib-resistant constitutive NF-kappaB activity in mantle cell lymphoma

1 reference

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7 December 2018

Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib*

1 reference

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Routine use of immunophenotype by flow cytometry in tissues with suspected hematological malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/21907693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of GRP78 to mitochondria under the unfolded protein response

1 reference

https://pubmed.ncbi.nlm.nih.gov/21907693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective Inhibition of I B Kinase Sensitizes Mantle Cell Lymphoma B Cells to TRAIL by Decreasing Cellular FLIP Level

1 reference

https://pubmed.ncbi.nlm.nih.gov/21907693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1016/J.AJPATH.2011.07.031

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21907693%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

release_wkyabtzmpnawpfhewnerhu4vvq

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24 November 2022

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12 February 2020

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Europe PubMed Central

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12 February 2020

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