(Q28279743)

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Aggressive lymphomas

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Europe PubMed Central

Aggressive lymphomas (English)

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2

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author name string

Georg Lenz

1

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publication date

15 April 2010

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The New England Journal of Medicine

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362

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15

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1417-29

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The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IRF4 addiction in multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of inflammation, cytokine expression, and germinal center formation by BCL-6

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

B cell antigen receptor signaling 101.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Connective tissue growth factor-specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The who, how and where of antigen presentation to B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Src-family kinases in B-cell development and signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AID is required for c-myc/IgH chromosome translocations in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear and cytoplasmic AID in extrafollicular and germinal center B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signatures of the immune response

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATM prevents the persistence and propagation of chromosome breaks in lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30+ Hodgkin cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AID is required for germinal center-derived lymphomagenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of the Bcl6 gene results in an impaired germinal center formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stromal gene signatures in large-B-cell lymphomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation and function of NF-kappaB transcription factors in the immune system

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequent inactivation of A20 in B-cell lymphomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

H2AX prevents DNA breaks from progressing to chromosome breaks and translocations

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular footprints of a germinal center derivation of human IgM+(IgD+)CD27+ B cells and the dynamics of memory B cell generation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular diagnosis of Burkitt's lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Germinal-center organization and cellular dynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-{kappa}B pathways in subtypes of diffuse large B-cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms promoting translocations in editing and switching peripheral B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A loss-of-function RNA interference screen for molecular targets in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the AID protein in normal and neoplastic B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncogenic CARD11 mutations in human diffuse large B cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tracking CD40 signaling during germinal center development

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Migratory neighbors and distant invaders: tumor-associated niche cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of genome profiles for identification of distinct subgroups of diffuse large B-cell lymphoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two levels of protection for the B cell genome during somatic hypermutation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic catastrophe as a means to cancer cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional analysis of the B cell germinal center reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homozygous deletion of SOCS1 in primary mediastinal B-cell lymphoma detected by CGH to BAC microarrays

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive STAT6 activation in primary mediastinal large B-cell lymphoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20393178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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