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ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation
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Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
title
ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation
(English)
1 reference
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Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
author
Henrik Hammarén
series ordinal
1
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Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
Daniela Ungureanu
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2
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Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
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4 March 2020
Stevan R Hubbard
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5
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Europe PubMed Central
PMC publication ID
4403165
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
author name string
Jean Grisouard
series ordinal
3
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PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
Radek C Skoda
series ordinal
4
1 reference
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Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
Olli Silvennoinen
series ordinal
6
1 reference
stated in
Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
language of work or name
English
0 references
publication date
30 March 2015
1 reference
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Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
published in
Proceedings of the National Academy of Sciences of the United States of America
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Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
volume
112
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Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
issue
15
1 reference
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Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
page(s)
4642-4647
1 reference
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Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
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Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase
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Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition
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A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties
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Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases
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Analysis of steady-state Förster resonance energy transfer data by avoiding pitfalls: interaction of JAK2 tyrosine kinase with N-methylanthraniloyl nucleotides.
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Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F
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The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling
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The constitutive activation of Jak2-V617F is mediated by a π stacking mechanism involving phenylalanines 595 and 617.
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JAK2 V617F constitutive activation requires JH2 residue F595: a pseudokinase domain target for specific inhibitors
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Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases
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Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation
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Integrin-linked kinase is an adaptor with essential functions during mouse development
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27 July 2018
ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor
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27 July 2018
Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F.
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27 July 2018
Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation
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27 July 2018
A gain-of-function mutation of JAK2 in myeloproliferative disorders
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27 July 2018
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
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27 July 2018
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
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27 July 2018
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
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27 July 2018
Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain
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PubMed Central
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27 July 2018
The protein kinase complement of the human genome
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27 July 2018
The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction
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A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling
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27 July 2018
Regulation of the Jak2 tyrosine kinase by its pseudokinase domain
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27 July 2018
Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains
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27 July 2018
Structural and functional basis for JAK3-deficient severe combined immunodeficiency
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27 July 2018
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27 July 2018
The JH2 domain and SH2-JH2 linker regulate JAK2 activity: A detailed kinetic analysis of wild type and V617F mutant kinase domains.
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26 September 2018
An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 Pseudokinase
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26 September 2018
Comprehensive review of JAK inhibitors in myeloproliferative neoplasms.
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26 September 2018
Modulation of Activation-Loop Phosphorylation by JAK Inhibitors Is Binding Mode Dependent
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26 September 2018
Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies
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26 September 2018
Biochemical, proteomic, structural, and thermodynamic characterizations of integrin-linked kinase (ILK): cross-validation of the pseudokinase.
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26 September 2018
PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity.
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26 September 2018
Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site
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26 September 2018
Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice
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26 September 2018
Catalytic independent functions of a protein kinase as revealed by a kinase-dead mutant: study of the Lys72His mutant of cAMP-dependent kinase
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26 September 2018
Evolutionary analysis for functional divergence of Jak protein kinase domains and tissue-specific genes
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
26 September 2018
Identifiers
DOI
10.1073/PNAS.1423201112
1 reference
stated in
Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
ADS bibcode
2015PNAS..112.4642H
0 references
PMC publication ID
4403165
1 reference
stated in
Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
PubMed publication ID
25825724
1 reference
stated in
Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
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