Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q35484880)
Watch
English
ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation
scientific article
In more languages
default for all languages
No label defined
No description defined
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
title
ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
author
Henrik Hammarén
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
Daniela Ungureanu
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
Stevan R Hubbard
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
author name string
Jean Grisouard
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
Radek C Skoda
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
Olli Silvennoinen
series ordinal
6
1 reference
stated in
Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
language of work or name
English
0 references
publication date
30 March 2015
1 reference
stated in
Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
published in
Proceedings of the National Academy of Sciences of the United States of America
1 reference
stated in
Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
volume
112
1 reference
stated in
Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
issue
15
1 reference
stated in
Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
page(s)
4642-4647
1 reference
stated in
Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
cites work
Recently targeted kinases and their inhibitors-the path to clinical trials
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
Analysis of steady-state Förster resonance energy transfer data by avoiding pitfalls: interaction of JAK2 tyrosine kinase with N-methylanthraniloyl nucleotides.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
JAK/STAT signaling in hematological malignancies.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
The constitutive activation of Jak2-V617F is mediated by a π stacking mechanism involving phenylalanines 595 and 617.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
JAK2 V617F constitutive activation requires JH2 residue F595: a pseudokinase domain target for specific inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
Integrin-linked kinase is an adaptor with essential functions during mouse development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
A gain-of-function mutation of JAK2 in myeloproliferative disorders
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
The protein kinase complement of the human genome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
Regulation of the Jak2 tyrosine kinase by its pseudokinase domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
Structural and functional basis for JAK3-deficient severe combined immunodeficiency
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
VMD: visual molecular dynamics
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
27 July 2018
The JH2 domain and SH2-JH2 linker regulate JAK2 activity: A detailed kinetic analysis of wild type and V617F mutant kinase domains.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
26 September 2018
An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 Pseudokinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
26 September 2018
Comprehensive review of JAK inhibitors in myeloproliferative neoplasms.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
26 September 2018
Modulation of Activation-Loop Phosphorylation by JAK Inhibitors Is Binding Mode Dependent
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
26 September 2018
Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
26 September 2018
Biochemical, proteomic, structural, and thermodynamic characterizations of integrin-linked kinase (ILK): cross-validation of the pseudokinase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
26 September 2018
PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
26 September 2018
Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
26 September 2018
Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
26 September 2018
Catalytic independent functions of a protein kinase as revealed by a kinase-dead mutant: study of the Lys72His mutant of cAMP-dependent kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
26 September 2018
Evolutionary analysis for functional divergence of Jak protein kinase domains and tissue-specific genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403165
retrieved
26 September 2018
Identifiers
DOI
10.1073/PNAS.1423201112
1 reference
stated in
Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
ADS bibcode
2015PNAS..112.4642H
0 references
PMC publication ID
4403165
1 reference
stated in
Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
PubMed publication ID
25825724
1 reference
stated in
Europe PubMed Central
PMC publication ID
4403165
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25825724%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit