(Q35509663)

25700521

8 August 2017

title

Kinase dynamics. Using ancient protein kinases to unravel a modern cancer drug's mechanism (English)

1 reference

8 August 2017

1

1 reference

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3 June 2020

Marc Hoemberger

3

1 reference

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3 June 2020

Steffen Kutter

4

1 reference

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3 June 2020

Adelajda Zorba

5

1 reference

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3 June 2020

Renee Otten

8

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3 June 2020

author name string

R V Agafonov

2

1 reference

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3 June 2020

J Halpin

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25700521%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

V Buosi

7

1 reference

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3 June 2020

D Waterman

9

1 reference

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3 June 2020

D L Theobald

10

1 reference

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3 June 2020

D Kern

11

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3 June 2020

language of work or name

English

0 references

publication date

1 February 2015

1 reference

8 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25700521%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

volume

347

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3 June 2020

issue

6224

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3 June 2020

page(s)

882-886

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25700521%20AND%20SRC:MED&resulttype=core&format=json

Energetic dissection of Gleevec's selectivity toward human tyrosine kinases.

3 June 2020

cites work

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The genomic and cellular foundations of animal origins

12 July 2018

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Conservation of Protein Structure over Four Billion Years

12 July 2018

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Evolutionary biochemistry: revealing the historical and physical causes of protein properties.

12 July 2018

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Explaining why Gleevec is a specific and potent inhibitor of Abl kinase

12 July 2018

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The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling

12 July 2018

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Single-molecule paleoenzymology probes the chemistry of resurrected enzymes

12 July 2018

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Protein kinases: evolution of dynamic regulatory proteins

12 July 2018

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Analyzing protein structure and function using ancestral gene reconstruction

12 July 2018

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Molecular dynamics simulations show that conformational selection governs the binding preferences of imatinib for several tyrosine kinases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405104

Defining the conserved internal architecture of a protein kinase.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405104

Retracing evolution of red fluorescence in GFP-like proteins from Faviina corals

12 July 2018

1 reference

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Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405104

Tyrosine phosphorylation: thirty years and counting

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405104

A conserved protonation-dependent switch controls drug binding in the Abl kinase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405104

Crystal structure of the T315I Abl mutant in complex with the aurora kinases inhibitor PHA-739358

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405104

Mechanistic approaches to the study of evolution: the functional synthesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405104

c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405104

Assessing the accuracy of ancestral protein reconstruction methods

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405104

Missense meanderings in sequence space: a biophysical view of protein evolution

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405104

Joint Bayesian Estimation of Alignment and Phylogeny

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405104

The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405104

Strategies to overcome resistance to targeted protein kinase inhibitors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405104

Ancestral sequence reconstruction in primate mitochondrial DNA: compositional bias and effect on functional inference.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405104

Inferring the palaeoenvironment of ancient bacteria on the basis of resurrected proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405104

Evolution of protein kinase signaling from yeast to man

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4405104

Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)

12 July 2018

1 reference

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

12 July 2018

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An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates

12 July 2018

1 reference

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Palaeotemperature trend for Precambrian life inferred from resurrected proteins

12 July 2018

1 reference

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PAML 4: phylogenetic analysis by maximum likelihood

26 September 2018

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High yield bacterial expression of active c-Abl and c-Src tyrosine kinases

21 January 2018

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21 January 2018

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Scaling and assessment of data quality

21 January 2018

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21 January 2018

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21 January 2018

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REFMAC5 dictionary: organization of prior chemical knowledge and guidelines for its use

21 January 2018

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Features and development of Coot

21 January 2018

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MolProbity: all-atom structure validation for macromolecular crystallography

21 January 2018

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Thermofluor-based high-throughput stability optimization of proteins for structural studies

21 January 2018

1 reference

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Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds

21 January 2018

1 reference

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A Src-like inactive conformation in the abl tyrosine kinase domain

21 January 2018

1 reference

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Structural basis for the autoinhibition of c-Abl tyrosine kinase

21 January 2018

1 reference

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The Different Flexibility of c-Src and c-Abl Kinases Regulates the Accessibility of a Druggable Inactive Conformation

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1126/SCIENCE.AAA1823

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25700521%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25700521%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

25700521

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25700521%20AND%20SRC:MED&resulttype=core&format=json