(Q34439602)

2 August 2017

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title

Missense meanderings in sequence space: a biophysical view of protein evolution (English)

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2 August 2017

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3

Daniel L Hartl

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2 August 2017

Mark A DePristo

1

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2 August 2017

Daniel M Weinreich

series ordinal

2

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2 August 2017

publication date

1 September 2005

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2 August 2017

published in

Nature Reviews Genetics

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2 August 2017

volume

6

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2 August 2017

issue

9

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2 August 2017

page(s)

678-687

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Is the evolution of insulin Darwinian or due to selectively neutral mutation?

2 August 2017

cites work

1 reference

Bayesian analysis suggests that most amino acid replacements in Drosophila are driven by positive selection

21 January 2018

1 reference

The rate of compensatory mutation in the DNA bacteriophage phiX174

21 January 2018

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Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs

21 January 2018

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Dobzhansky-Muller incompatibilities in protein evolution

21 January 2018

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Protein folding and misfolding

21 January 2018

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Structural bases of stability-function tradeoffs in enzymes

21 January 2018

1 reference

A relationship between protein stability and protein function

21 January 2018

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Two-state models of protein folding kinetics

21 January 2018

1 reference

Topology, stability, sequence, and length: defining the determinants of two-state protein folding kinetics

21 January 2018

1 reference

The Stability of Globular Protein

21 January 2018

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Mutational analysis of the propensity for amyloid formation by a globular protein

21 January 2018

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Effects of macromolecular crowding on protein folding and aggregation

21 January 2018

1 reference

Prediction of "aggregation-prone" and "aggregation-susceptible" regions in proteins associated with neurodegenerative diseases

21 January 2018

1 reference

Rationalization of the effects of mutations on peptide and protein aggregation rates.

21 January 2018

1 reference

Kinetic partitioning of protein folding and aggregation.

21 January 2018

1 reference

A systematic exploration of the influence of the protein stability on amyloid fibril formation in vitro

21 January 2018

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Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

21 January 2018

1 reference

Molecular chaperones in the cytosol: from nascent chain to folded protein

21 January 2018

1 reference

Folding and aggregation of TEM beta-lactamase: analogies with the formation of inclusion bodies in Escherichia coli

21 January 2018

1 reference

Protein degradation and protection against misfolded or damaged proteins

21 January 2018

1 reference

Defective folding and rapid degradation of mutant proteins is a common disease mechanism in genetic disorders

21 January 2018

1 reference

Genetic analysis of protein stability and function

21 January 2018

1 reference

Review: Protein function at thermal extremes: balancing stability and flexibility

21 January 2018

1 reference

The role of dynamics in enzyme activity

21 January 2018

1 reference

21 January 2018

Proteins and temperature

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Natively unfolded proteins

21 January 2018

1 reference

Chaperonins govern growth of Escherichia coli at low temperatures.

21 January 2018

1 reference

Structural and thermodynamic analysis of the packing of two alpha-helices in bacteriophage T4 lysozyme

21 January 2018

1 reference

Predicting changes in the stability of proteins and protein complexes: a study of more than 1000 mutations

21 January 2018

1 reference

The folding of an enzyme. I. Theory of protein engineering analysis of stability and pathway of protein folding

21 January 2018

1 reference

Mutational effects on protein stability

21 January 2018

1 reference

Site-saturation studies of beta-lactamase: production and characterization of mutant beta-lactamases with all possible amino acid substitutions at residue 71

21 January 2018

1 reference

Bacteriophage lambda cro mutations: effects on activity and intracellular degradation

21 January 2018

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Protein aggregation in Escherichia coli: role of proteases

21 January 2018

1 reference

Investigating the effects of mutations on protein aggregation in the cell.

21 January 2018

1 reference

Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins

21 January 2018

1 reference

Nature disfavors sequences of alternating polar and non-polar amino acids: implications for amyloidogenesis

21 January 2018

1 reference

Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case

21 January 2018

1 reference

Adjustment of conformational flexibility is a key event in the thermal adaptation of proteins

21 January 2018

1 reference

Amyloid as a natural product

21 January 2018

1 reference

Two exposed amino acid residues confer thermostability on a cold shock protein

21 January 2018

1 reference

Some like it hot: the molecular determinants of protein thermostability

21 January 2018

1 reference

Compensatory adaptation to the deleterious effect of antibiotic resistance in Salmonella typhimurium

21 January 2018

1 reference

Alteration of T4 lysozyme structure by second-site reversion of deleterious mutations

21 January 2018

1 reference

Biological cost and compensatory evolution in fusidic acid-resistant Staphylococcus aureus

21 January 2018

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Virulence of antibiotic-resistant Salmonella typhimurium

21 January 2018

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Compensated deleterious mutations in insect genomes

21 January 2018

1 reference

Restoring allosterism with compensatory mutations in hemoglobin

21 January 2018

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Mutually compensatory mutations during evolution of the tetramerization domain of tumor suppressor p53 lead to impaired hetero-oligomerization

21 January 2018

1 reference

The biological cost of antibiotic resistance

21 January 2018

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Resistance of human immunodeficiency virus type 1 to protease inhibitors: selection of resistance mutations in the presence and absence of the drug.

21 January 2018

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Between genotype and phenotype: protein chaperones and evolvability

21 January 2018

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Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance

21 January 2018

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Thermodynamic prediction of protein neutrality

21 January 2018

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21 January 2018

Biochemical evolution

1 reference

An examination of the constancy of the rate of molecular evolution

21 January 2018

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Adaptive protein evolution at the Adh locus in Drosophila

21 January 2018

1 reference

Adaptive protein evolution in Drosophila

21 January 2018

1 reference

The genetic theory of adaptation: a brief history

21 January 2018

1 reference

Natural Selection and the Concept of a Protein Space

21 January 2018

1 reference

Evolution of functionally conserved enhancers can be accelerated in large populations: a population-genetic model.

21 January 2018

1 reference

Protein misfolding and degradation in genetic diseases.

21 January 2018

1 reference

Misfolding, degradation, and aggregation of variant proteins. The molecular pathogenesis of short chain acyl-CoA dehydrogenase (SCAD) deficiency

21 January 2018

1 reference

Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

21 January 2018

1 reference

Games played by rogue proteins in prion disorders and Alzheimer's disease

21 January 2018

1 reference

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

21 January 2018

1 reference

Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

21 January 2018

1 reference

Big-benefit mutations in a bacteriophage inhibited with heat

21 January 2018

1 reference

Neutral evolution of model proteins: diffusion in sequence space and overdispersion

21 January 2018

1 reference

Positive selection at sites of multiple amino acid replacements since rat–mouse divergence

21 January 2018

1 reference

The coupon collector and the suppressor mutation: estimating the number of compensatory mutations by maximum likelihood.

21 January 2018

1 reference

Global suppression of protein folding defects and inclusion body formation

31 March 2020

1 reference

Patterns of nonadditivity between pairs of stability mutations in staphylococcal nuclease

31 March 2020

1 reference

Protein stability effects of a complete set of alanine substitutions in Arc repressor

31 March 2020

1 reference

Amino acid substitutions that increase the thermal stability of the lambda Cro protein

31 March 2020

1 reference

Adaptation to the fitness costs of antibiotic resistance in Escherichia coli

31 March 2020

1 reference

Evolutionary Divergence and Convergence in Proteins

31 March 2020

1 reference

On the constancy of the evolutionary rate of cistrons

31 March 2020

1 reference

Studies on protein stability with T4 lysozyme

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRG1672

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Dimensions Publication ID

2 August 2017

1003868583

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1 reference