(Q35538846)

English

Acetylcholinesterase: a multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease

scientific article published on January 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

1 reference

Europe PubMed Central

Acetylcholinesterase: a multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease (English)

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Alzheimer's disease

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Joel L. Sussman

object named as

Joel L Sussman

4

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author name string

Harry M Greenblatt

1

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Hay Dvir

2

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Israel Silman

3

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

1 January 2003

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Journal of Molecular Neuroscience

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

20

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

369-383

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

https://scigraph.springernature.com/pub.10.1385/jmn:20:3:369

0 references

The rationale for E2020 as a potent acetylcholinesterase inhibitor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of inhibition of cholinesterases by huperzine A

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huperzine A, a potential therapeutic agent for treatment of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product This work was supported by the Research Grants Council of Hong Kong (HKUST6156/97M), the Biotechnology Research Institute (HKUST), the

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three-dimensional structure of a complex of E2020 with acetylcholinesterase from Torpedo californica

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

"Back door" opening implied by the crystal structure of a carbamoylated acetylcholinesterase

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A cholinesterase genes server (ESTHER): a database of cholinesterase-related sequences for multiple alignments, phylogenetic relationships, mutations and structural data retrieval.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and dynamics of the active site gorge of acetylcholinesterase: synergistic use of molecular dynamics simulation and X-ray crystallography

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterodimeric Tacrine-Based Acetylcholinesterase Inhibitors: Investigating Ligand−Peripheral Site Interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anionic subsites of the acetylcholinesterase from Torpedo californica: affinity labelling with the cationic reagent N,N-dimethyl-2-phenyl-aziridinium

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain selective inhibition of acetylcholinesterase: a novel approach to therapy for Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potencies and stereoselectivities of enantiomers of huperzine A for inhibition of rat cortical acetylcholinesterase

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical trials of a new anticholinesterase agent, galanthamine, in anesthesiology

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three-dimensional structure of a complex of galanthamine (Nivalin) with acetylcholinesterase from Torpedo californica: implications for the design of new anti-Alzheimer drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of the binding sites of huperzine A in acetylcholinesterase by docking studies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and crystallization of a dimeric form of acetylcholinesterase from Torpedo californica subsequent to solubilization with phosphatidylinositol-specific phospholipase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From the Food and Drug Administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The nicotinic allosteric potentiating ligand galantamine facilitates synaptic transmission in the mammalian central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physostigmine, galanthamine and codeine act as ‘noncompetitive nicotinic receptor agonists’ on clonal rat pheochromocytoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Anti-cholinesterase activity of huperzine A]

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and functional characterization of a new agonist site on nicotinic acetylcholine receptors of cultured hippocampal neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nivalin in the treatment of residual post-polio paralysis and pseudo-hypertrophic muscular dystrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrotactins: a class of adhesion proteins with conserved electrostatic and structural motifs

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylcholine binding by a synthetic receptor: implications for biological recognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonist responses of neuronal nicotinic acetylcholine receptors are potentiated by a novel class of allosterically acting ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Trials in the treatment of facial nerve paralysis using nivaline]

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long chain analogs of physostigmine as potential drugs for Alzheimer's disease: new insights into the mechanism of action in the inhibition of acetylcholinesterase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three-dimensional structures ofDrosophila melanogasteracetylcholinesterase and of its complexes with two potent inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anticholinesterases: medical applications of neurochemical principles.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Golden age of insecticide research: past, present, or future?

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effective charge on acetylcholinesterase active sites determined from the ionic strength dependence of association rate constants with cationic ligands.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The alpha/beta hydrolase fold

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huprine X is a novel high-affinity inhibitor of acetylcholinesterase that is of interest for treatment of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cholinesterases: from genes to proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A modular treatment of molecular traffic through the active site of cholinesterase

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibition of human acetylcholinesterase by galanthamine in vitro and in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformational analyses and molecular-shape comparisons of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacology of galanthamine and its analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accurate prediction of the bound conformation of galanthamine in the active site of Torpedo californica acetylcholinesterase using molecular docking

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino acid residues controlling acetylcholinesterase and butyrylcholinesterase specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site of fasciculin interaction with acetylcholinesterase

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYSDOC program

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrostatic attraction by surface charge does not contribute to the catalytic efficiency of acetylcholinesterase

1 reference

https://pubmed.ncbi.nlm.nih.gov/14501022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1385/JMN:20:3:369

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Dimensions Publication ID

0 references

release_4pb5372gsfdcfir7trzrgwsoq4

1 reference

https://api.fatcat.wiki/v0/release/4pb5372gsfdcfir7trzrgwsoq4

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

ResearchGate publication ID

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