(Q35541632)

8 August 2017

title

Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing (English)

1 reference

8 August 2017

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Shinsuke Araki

1

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author name string

Ryo Dairiki

2

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8 August 2017

Yusuke Nakayama

3

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8 August 2017

Aiko Murai

4

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8 August 2017

Risa Miyashita

5

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8 August 2017

Misa Iwatani

6

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8 August 2017

Toshiyuki Nomura

7

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8 August 2017

Osamu Nakanishi

8

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8 August 2017

language of work or name

English

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publication date

12 January 2015

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8 August 2017

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8 August 2017

volume

10

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8 August 2017

issue

1

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8 August 2017

page(s)

e0116929

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Creative Commons Attribution 4.0 International

8 August 2017

copyright license

start time

12 January 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing

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27 July 2018

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The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region

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Arginine methylation controls the subcellular localization and functions of the oncoprotein splicing factor SF2/ASF

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27 July 2018

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Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

27 July 2018

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The gene encoding the splicing factor SF2/ASF is a proto-oncogene

27 July 2018

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Targeting the RNA splicing machinery as a novel treatment strategy for pancreatic carcinoma

27 July 2018

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The spliceosome: a novel multi-faceted target for therapy

27 July 2018

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27 July 2018

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27 July 2018

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Differential effects of hyperphosphorylation on splicing factor SRp55

27 July 2018

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Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity

27 July 2018

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The cellular localization of the murine serine/arginine-rich protein kinase CLK2 is regulated by serine 141 autophosphorylation

27 July 2018

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The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution

27 July 2018

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27 July 2018

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Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing

27 July 2018

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27 July 2018

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The development and application of small molecule modulators of SF3b as therapeutic agents for cancer.

26 September 2018

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The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation

26 September 2018

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26 September 2018

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Shuttling SR proteins: more than splicing factors

26 September 2018

1 reference

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Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy

26 September 2018

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Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones

26 September 2018

1 reference

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The emerging role of splicing factors in cancer

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291223

Splicing factor SF3b as a target of the antitumor natural product pladienolide.

26 September 2018

1 reference

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Alternative splicing in the human, mouse and rat genomes is associated with an increased frequency of exon creation and/or loss

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291223

Serine-arginine protein kinase 1 overexpression is associated with tumorigenic imbalance in mitogen-activated protein kinase pathways in breast, colonic, and pancreatic carcinomas

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25581376

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Distribution of pre-mRNA splicing factors at sites of RNA polymerase II transcription

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25581376

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0116929

1 reference

8 August 2017

0 references

1 reference

8 August 2017

1 reference