(Q35543143)

8 August 2017

title

Serine protease acylation proceeds with a subtle re-orientation of the histidine ring at the tetrahedral intermediate (English)

1 reference

8 August 2017

Yanzi Zhou

1

1 reference

8 August 2017

Yingkai Zhang

series ordinal

2

1 reference

8 August 2017

language of work or name

English

0 references

publication date

29 November 2010

1 reference

8 August 2017

published in

Chemical Communications

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8 August 2017

volume

47

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8 August 2017

issue

5

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8 August 2017

page(s)

1577-1579

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A proton-shuttle reaction mechanism for histone deacetylase 8 and the catalytic role of metal ions

8 August 2017

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27 July 2018

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Structure of a serine protease poised to resynthesize a peptide bond

27 July 2018

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Active site cysteine is protonated in the PAD4 Michaelis complex: evidence from Born-Oppenheimer ab initio QM/MM molecular dynamics simulations

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How do SET-domain protein lysine methyltransferases achieve the methylation state specificity? Revisited by Ab initio QM/MM molecular dynamics simulations

27 July 2018

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27 July 2018

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27 July 2018

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Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates

27 July 2018

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Enzyme:substrate hydrogen bond shortening during the acylation phase of serine protease catalysis.

27 July 2018

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27 July 2018

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alpha-lytic protease can exist in two separately stable conformations with different His57 mobilities and catalytic activities

27 July 2018

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27 July 2018

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27 July 2018

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Unusual 1H NMR chemical shifts support (His) C(epsilon) 1...O==C H-bond: proposal for reaction-driven ring flip mechanism in serine protease catalysis

27 July 2018

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Protease inhibitors: current status and future prospects

27 July 2018

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Fractionation factors and activation energies for exchange of the low barrier hydrogen bonding proton in peptidyl trifluoromethyl ketone complexes of chymotrypsin

27 July 2018

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27 July 2018

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Short strong hydrogen bonds: can they explain enzymic catalysis?

27 July 2018

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Refined 1.6 A resolution crystal structure of the complex formed between porcine beta-trypsin and MCTI-A, a trypsin inhibitor of the squash family. Detailed comparison with bovine beta-trypsin and its complex

27 July 2018

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Role of a Buried Acid Group in the Mechanism of Action of Chymotrypsin

27 July 2018

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How do serine proteases really work?

27 July 2018

1 reference

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Subangstrom crystallography reveals that short ionic hydrogen bonds, and not a His-Asp low-barrier hydrogen bond, stabilize the transition state in serine protease catalysis.

27 July 2018

1 reference

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Analysis of catalytic mechanism of serine proteases. Viability of the ring-flip hypothesis

21 January 2018

1 reference

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Role of Asp102 in the catalytic relay system of serine proteases: a theoretical study

21 January 2018

1 reference

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Theoretical Perspectives on the Reaction Mechanism of Serine Proteases: The Reaction Free Energy Profiles of the Acylation Process

21 January 2018

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Theoretical studies on the deacylation step of serine protease catalysis in the gas phase, in solution, and in elastase

21 January 2018

1 reference

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Ab initio QM/MM dynamics simulation of the tetrahedral intermediate of serine proteases: insights into the active site hydrogen-bonding network

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC04112B

Highly dissociative and concerted mechanism for the nicotinamide cleavage reaction in Sir2Tm enzyme suggested by ab initio QM/MM molecular dynamics simulations

21 January 2018

1 reference

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On low-barrier hydrogen bonds and enzyme catalysis.

21 January 2018

1 reference

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Structural Analyses on Intermediates in Serine Protease Catalysis

21 January 2018

1 reference

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Improved pseudobonds for combined ab initio quantum mechanical/molecular mechanical methods

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21116528

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Low-barrier hydrogen bond hypothesis in the catalytic triad residue of serine proteases: correlation between structural rearrangement and chemical shifts in the acylation process

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21116528

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The tortuous story of Asp ... His ... Ser: structural analysis of alpha-chymotrypsin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21116528

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1039/C0CC04112B

1 reference

8 August 2017

1 reference

8 August 2017

1 reference