(Q43197493)

English

Highly dissociative and concerted mechanism for the nicotinamide cleavage reaction in Sir2Tm enzyme suggested by ab initio QM/MM molecular dynamics simulations

scientific article published in December 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

Highly dissociative and concerted mechanism for the nicotinamide cleavage reaction in Sir2Tm enzyme suggested by ab initio QM/MM molecular dynamics simulations (English)

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

1 reference

based on heuristic

inferred from title

author name string

Po Hu

1

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

Shenglong Wang

2

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

Yingkai Zhang

3

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

language of work or name

0 references

publication date

1 December 2008

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

Journal of the American Chemical Society

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

130

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

49

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

16721-16728

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

Free energies of chemical reactions in solution and in enzymes with ab initio quantum mechanics/molecular mechanics methods

1 reference

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How do SET-domain protein lysine methyltransferases achieve the methylation state specificity? Revisited by Ab initio QM/MM molecular dynamics simulations

1 reference

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Sir2 deacetylases exhibit nucleophilic participation of acetyl-lysine in NAD+ cleavage.

1 reference

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Ab initio quantum mechanical/molecular mechanical molecular dynamics simulation of enzyme catalysis: the case of histone lysine methyltransferase SET7/9.

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1 reference

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Structural Basis for Nicotinamide Inhibition and Base Exchange in Sir2 Enzymes

1 reference

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Ab initio quantum chemical and mixed quantum mechanics/molecular mechanics (QM/MM) methods for studying enzymatic catalysis

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Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme

1 reference

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Structure and chemistry of the Sir2 family of NAD+-dependent histone/protein deactylases

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Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

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Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases

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Structure of a Sir2 enzyme bound to an acetylated p53 peptide

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Quantum mechanical methods for enzyme kinetics

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Identifiers

10.1021/JA807269J

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

ResearchGate publication ID

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