Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q44800960)
Watch
English
Structural basis for the mechanism and regulation of Sir2 enzymes.
scientific article published in March 2004
In more languages
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15023335
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15023335%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
title
Structural basis for the mechanism and regulation of Sir2 enzymes
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15023335
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15023335%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
author
Jef D Boeke
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15023335
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15023335%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
Jose L Avalos
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15023335
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15023335%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
Cynthia Wolberger
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15023335
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15023335%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
author name string
José L Avalos
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15023335
retrieved
6 December 2017
Cynthia Wolberger
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15023335
retrieved
6 December 2017
publication date
1 March 2004
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15023335
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15023335%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
published in
Molecular Cell
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15023335
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15023335%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
volume
13
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15023335
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15023335%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
issue
5
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15023335
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15023335%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
page(s)
639-648
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15023335
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15023335%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
cites work
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of a Sir2 enzyme bound to an acetylated p53 peptide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Unusual conformation of nicotinamide adenine dinucleotide (NAD) bound to diphtheria toxin: a comparison with NAD bound to the oxidoreductase enzymes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional silencing in yeast is associated with reduced nucleosome acetylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural basis for the NAD-dependent deacetylase mechanism of Sir2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of the histone deacetylase SIRT2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of Nicotinamide Inhibition and Transglycosidation by Sir2 Histone/Protein Deacetylases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Improved methods for building protein models in electron density maps and the location of errors in these models
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Negative control of p53 by Sir2alpha promotes cell survival under stress
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structure of a SIR2 homolog-NAD complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The amide rotational barriers in picolinamide and nicotinamide: NMR and ab initio studies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Processing of X-ray diffraction data collected in oscillation mode
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SIR2 family of NAD(+)-dependent protein deacetylases.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure and catalytic mechanism of a SET domain protein methyltransferase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MOLREP: an Automated Program for Molecular Replacement
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure and autoregulation of the yeast Hst2 homolog of Sir2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of the Yeast Hst2 Protein Deacetylase in Ternary Complex with 2′-O-Acetyl ADP Ribose and Histone Peptide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900082-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1097-2765(04)00082-6
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15023335
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15023335%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
PubMed publication ID
15023335
1 reference
stated in
Europe PubMed Central
PubMed publication ID
15023335
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15023335%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit