(Q35545492)

English

Flavopiridol induces BCL-2 expression and represses oncogenic transcription factors in leukemic blasts from adults with refractory acute myeloid leukemia

scientific article published on 5 July 2011

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Flavopiridol induces BCL-2 expression and represses oncogenic transcription factors in leukemic blasts from adults with refractory acute myeloid leukemia (English)

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

1 reference

based on heuristic

inferred from title

author name string

Dwella M Nelson

1

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Biju Joseph

2

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Joelle Hillion

3

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Jodi Segal

4

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Judith E Karp

5

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Linda M S Resar

6

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

publication date

5 July 2011

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Leukemia & Lymphoma

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

52

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

1999-2006

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures

1 reference

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Phase 1 and pharmacokinetic study of bolus-infusion flavopiridol followed by cytosine arabinoside and mitoxantrone for acute leukemias

1 reference

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Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia

1 reference

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12 July 2018

Clinical activity of sequential flavopiridol, cytosine arabinoside, and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia

1 reference

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Upregulation of MMP-2 by HMGA1 promotes transformation in undifferentiated, large-cell lung cancer.

1 reference

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HMGA1 correlates with advanced tumor grade and decreased survival in pancreatic ductal adenocarcinoma

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New agents in acute myeloid leukemia: beyond cytarabine and anthracyclines

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Targeting signal transducer and activator of transcription signaling pathway in leukemias.

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HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma

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Cyclooxygenase inhibitors block uterine tumorigenesis in HMGA1a transgenic mice and human xenografts

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HMGA2 participates in transformation in human lung cancer

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An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors

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Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia

1 reference

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Cyclin-dependent kinase pathways as targets for cancer treatment

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Drug therapy for acute myeloid leukemia

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HMG-I/Y is a c-Jun/activator protein-1 target gene and is necessary for c-Jun-induced anchorage-independent growth in Rat1a cells

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12 July 2018

The HMG-I oncogene causes highly penetrant, aggressive lymphoid malignancy in transgenic mice and is overexpressed in human leukemia.

1 reference

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12 July 2018

Dominant-negative c-Jun (TAM67) target genes: HMGA1 is required for tumor promoter-induced transformation

1 reference

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12 July 2018

High-mobility group A1 proteins are overexpressed in human leukaemias

1 reference

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12 July 2018

HMG-I/Y in human breast cancer cell lines

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Complexities in the development of cyclin-dependent kinase inhibitor drugs

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Prediction of central nervous system embryonal tumour outcome based on gene expression

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Rational approaches to design of therapeutics targeting molecular markers

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The pattern of gene expression in human CD34(+) stem/progenitor cells

1 reference

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Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo

1 reference

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Mechanisms of action of flavopiridol

1 reference

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The oncogenic properties of the HMG-I gene family.

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HMG-I/Y, a new c-Myc target gene and potential oncogene

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12 July 2018

Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia.

1 reference

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Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6.

1 reference

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Preclinical and clinical development of cyclin-dependent kinase modulators

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1 reference

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1 reference

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Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy

1 reference

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Phase I and pharmacokinetic study of flavopiridol followed by 1-beta-D-arabinofuranosylcytosine and mitoxantrone in relapsed and refractory adult acute leukemias

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Sequence and analysis of the murine Hmgiy (Hmga1) gene locus.

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High mobility group protein HMGI(Y) enhances tumor cell growth, invasion, and matrix metalloproteinase-2 expression in prostate cancer cells

1 reference

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Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas.

1 reference

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21 January 2018

The high-mobility group A1 gene up-regulates cyclooxygenase 2 expression in uterine tumorigenesis.

1 reference

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Loss of the Bcl-2 phosphorylation loop domain is required to protect human myeloid leukemia cells from flavopiridol-mediated mitochondrial damage and apoptosis

1 reference

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21 January 2018

Timed sequential therapy of acute leukemia with flavopiridol: in vitro model for a phase I clinical trial

1 reference

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1 reference

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Sequential flavopiridol, cytosine arabinoside, and mitoxantrone: a phase II trial in adults with poor-risk acute myelogenous leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21728742

12 December 2020

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Identifiers

10.3109/10428194.2011.591012

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

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