(Q34224865)

31 July 2017

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title

Mechanisms of action of flavopiridol (English)

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31 July 2017

Sedlacek HH

1

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31 July 2017

publication date

1 May 2001

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Critical Reviews in Oncology Hematology

31 July 2017

published in

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31 July 2017

volume

38

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31 July 2017

issue

2

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31 July 2017

page(s)

139-170

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Synchronization of HeLa cell cultures by inhibition of DNA polymerase alpha with aphidicolin

31 July 2017

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Mutational analysis supports a structural model for the cell cycle protein kinase p34

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Regulation of cyclin D1 by calpain protease

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How proteolysis drives the cell cycle

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7 January 2021

Mitosis in transition

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Cyclin A-Cys41 does not undergo cell cycle-dependent degradation in Xenopus extracts

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Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor.

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7 January 2021

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

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Cyclin D1 protein expression and function in human breast cancer

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7 January 2021

Redundant cyclin overexpression and gene amplification in breast cancer cells

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7 January 2021

A novel cyclin encoded by a bcl1-linked candidate oncogene

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7 January 2021

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

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7 January 2021

A cell cycle regulator potentially involved in genesis of many tumor types

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7 January 2021

Control and activity of type-1 serine/threonine protein phosphatase during the cell cycle

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7 January 2021

Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes

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7 January 2021

p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.

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7 January 2021

Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins

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7 January 2021

The retinoblastoma gene family: cousins with overlapping interests

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7 January 2021

The retinoblastoma protein and cell cycle control

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7 January 2021

Retinoblastoma protein expressed in human non-Hodgkin's lymphoma cells generates resistance against radiation-induced apoptosis

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7 January 2021

Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes

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7 January 2021

Regulation and expression of retinoblastoma proteins p107 and p130 during 3T3-L1 adipocyte differentiation

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7 January 2021

Differential regulation of the retinoblastoma family of proteins during cell proliferation and differentiation

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7 January 2021

Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B

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7 January 2021

The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state.

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7 January 2021

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

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7 January 2021

Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth

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7 January 2021

Physical interaction of the retinoblastoma protein with human D cyclins

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7 January 2021

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

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7 January 2021

Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation

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7 January 2021

Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.

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7 January 2021

Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Correlation with decreased H1 kinase activity

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7 January 2021

A family of human cdc2-related protein kinases

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7 January 2021

Production of large numbers of mitotic mammalian cells by use of the reversible microtubule inhibitor Nocodazole

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7 January 2021

PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro

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7 January 2021

Targeting of CDK8 to a promoter-proximal RNA element demonstrates catalysis-dependent activation of gene expression.

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7 January 2021

Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

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7 January 2021

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

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7 January 2021

Identification of cytosolic aldehyde dehydrogenase 1 from non-small cell lung carcinomas as a flavopiridol-binding protein

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7 January 2021

The expanding role of cell cycle regulators

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7 January 2021

Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.

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7 January 2021

Participation of cyclin A in Myc-induced apoptosis.

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7 January 2021

Unrestricted cell cycling and cancer

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7 January 2021

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7 January 2021

Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death

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7 January 2021

Chemotherapy-induced apoptosis

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7 January 2021

The ras oncogene-mediated sensitization of human cells to topoisomerase II inhibitor-induced apoptosis.

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7 January 2021

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

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7 January 2021

Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis

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7 January 2021

Cell cycle-independent induction of apoptosis by the anti-tumor drug Flavopiridol in endothelial cells

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7 January 2021

Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death

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7 January 2021

Ordering the cell death pathway. Differential effects of BCL2, an interleukin-1-converting enzyme family protease inhibitor, and other survival agents on JNK activation in serum/nerve growth factor-deprived PC12 cells

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7 January 2021

Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress

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7 January 2021

The mechanism of Ara-C-induced apoptosis of differentiating cerebellar granule neurons

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7 January 2021

G1/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis

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7 January 2021

Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents

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7 January 2021

In vitro evaluation of flavopiridol, a novel cell cycle inhibitor, in bladder cancer

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7 January 2021

Cyclin D1 expression is regulated by the retinoblastoma protein

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7 January 2021

Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity.

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7 January 2021

The targeting of the cyclin D1 oncogene by an Epstein-Barr virus promoter in transgenic mice causes dysplasia in the tongue, esophagus and forestomach

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7 January 2021

Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress

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7 January 2021

p53 mutations in human cancers

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7 January 2021

The p53 tumour suppressor gene

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7 January 2021

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

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7 January 2021

The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation

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7 January 2021

Multisite phosphorylation and the integration of stress signals at p53.

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7 January 2021

Bcl-2 targets the protein kinase Raf-1 to mitochondria

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7 January 2021

The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein

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7 January 2021

The proto-oncogene Bcl-2 and its role in regulating apoptosis

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7 January 2021

Identification of a novel regulatory domain in Bcl-X(L) and Bcl-2.

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7 January 2021

Double identity for proteins of the Bcl-2 family

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7 January 2021

The AML1/ETO fusion protein activates transcription of BCL-2

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7 January 2021

A dominant interfering Myb mutant causes apoptosis in T cells

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7 January 2021

bcl-2 expression is reciprocal to p53 and c-myc expression in metastatic human colorectal cancer

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7 January 2021

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

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7 January 2021

A matter of life and cell death

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7 January 2021

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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7 January 2021

The Bcl-2 protein family: arbiters of cell survival

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7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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7 January 2021

Mitochondria and apoptosis

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7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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7 January 2021

Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis.

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7 January 2021

Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1.

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7 January 2021

Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independently of caspase-3 (CPP32)-like activity

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7 January 2021

Metabolism and effects of epidermal growth factor and related growth factors in mammals

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7 January 2021

Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene

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7 January 2021

Transcripts for transforming growth factors in human breast cancer: clinical correlates

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7 January 2021

The prognostic significance of transforming growth factors in human breast cancer

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7 January 2021

A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling

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7 January 2021

Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation

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7 January 2021

p185c-neu and epidermal growth factor receptor associate into a structure composed of activated kinases

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7 January 2021

ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor

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7 January 2021

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.

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7 January 2021

Epidermal growth factor-related peptides and their receptors in human malignancies

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7 January 2021

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

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7 January 2021

Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras

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7 January 2021

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

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7 January 2021

Receptors for epidermal growth factor and other polypeptide mitogens

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https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Protein-tyrosine kinases

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7 January 2021

The when and how of Src regulation

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7 January 2021

Involvement of pp60c-src with two major signaling pathways in human breast cancer

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7 January 2021

Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers

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7 January 2021

pp60c-src tyrosine kinase, myristylation, and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-src

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7 January 2021

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

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7 January 2021

Cell genetic evidence of correlation of intracellular translocation of protein kinase C (PKC) and PKC-mediated phosphorylation of 80-kDa protein with mitogenic action of tumor promoters

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7 January 2021

Lamin B phosphorylation by protein kinase calpha and proteolysis during apoptosis in human leukemia HL60 cells

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7 January 2021

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

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7 January 2021

The protein kinase C family: heterogeneity and its implications

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7 January 2021

Protein kinase C--a family affair

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7 January 2021

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1 reference

7 January 2021

Purification and characterisation of bovine brain protein kinase C isotypes alpha, beta and gamma

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Elevated activities of protein kinase C and tyrosine kinase correlate to leukemic cell aggressiveness

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Protein kinase C activity as marker for colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Alterations in protein kinase C isozymes alpha and beta 2 in activated Ha-ras containing papillomas in the absence of an increase in diacylglycerol

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Telomerase is controlled by protein kinase Calpha in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Cells that overproduce protein kinase C are more susceptible to transformation by an activated H-ras oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Synthesis of diacylglycerol de novo is responsible for permanent activation and down-regulation of protein kinase C in transformed cells

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Evidence for a role of phosphatidylcholine-hydrolysing phospholipase C in the regulation of protein kinase C by ras and src oncogenes.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Induction of apoptosis of cytokine-producing bladder cancer cells by adenovirus-mediated IkappaBalpha overexpression

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Induction of apoptosis with I-kappaB, the inhibitor of NF-kappaB.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Mechanism of telomerase induction during T cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

1 reference

7 January 2021

Activation of telomerase in a human tumor

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Telomeres and telomerase: a simple picture becomes complex

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Selective phosphorylation of human DNA methyltransferase by protein kinase C

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

The potential of protein kinase C as a target for anticancer treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Biochemistry of multidrug resistance mediated by the multidrug transporter

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Apoptosis induced by anticancer drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Multidrug resistance is more than MDR1 activity

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

The multidrug resistance P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

ABC Transporters: From Microorganisms to Man

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Multidrug resistance proteins and other drug transport-related resistance to natural product agents.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Cisplatin resistance in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Influence of myc overexpression on the phenotypic properties of Chinese hamster lung cells resistant to antitumor agents

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Human multidrug resistant KB cells overexpress protein kinase C: involvement in drug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Distinct patterns of phorbol ester-induced downregulation of protein kinase C activity in adriamycin-selected multidrug resistant and parental murine fibrosarcoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Phorbol esters induce multidrug resistance in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Partial reversal of multidrug resistance in human breast cancer cells by an N-myristoylated protein kinase C-alpha pseudosubstrate peptide

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Staurosporine, a potent inhibitor of C-kinase, enhances drug accumulation in multidrug-resistant cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Tissue-specific expression of three distinct types of rabbit protein kinase C.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Potent interaction of flavopiridol with MRP1

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Modulation by (iso)flavonoids of the ATPase activity of the multidrug resistance protein

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

c-fos-induced growth factor/vascular endothelial growth factor D induces angiogenesis in vivo and in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Angiogenesis modulates the tumour immune response

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Angiogenesis inhibitors overcome tumor induced endothelial cell anergy

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

Endothelial vascular cell adhesion molecule 1 expression is suppressed by melanoma and carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2800%2900124-4

7 January 2021

10.1016/S1040-8428(00)00124-4

Identifiers

DOI

1 reference

31 July 2017

1 reference