(Q35549387)

English

A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy

scientific article published on 23 March 2011

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scholarly article

1 reference

Europe PubMed Central

8 August 2017

A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy (English)

1 reference

Europe PubMed Central

8 August 2017

object named as

Natalie Cook

7

0 references

object named as

Basetti Madhu

5

0 references

10

object named as

David A Tuveson

1 reference

Europe PubMed Central

8 August 2017

author name string

Tashinga E Bapiro

1

1 reference

Europe PubMed Central

8 August 2017

Frances M Richards

2

1 reference

Europe PubMed Central

8 August 2017

Mae A Goldgraben

3

1 reference

Europe PubMed Central

8 August 2017

Kenneth P Olive

4

1 reference

Europe PubMed Central

8 August 2017

Kristopher K Frese

6

1 reference

Europe PubMed Central

8 August 2017

Michael A Jacobetz

8

1 reference

Europe PubMed Central

8 August 2017

Donna-Michelle Smith

9

1 reference

Europe PubMed Central

8 August 2017

John R Griffiths

11

1 reference

Europe PubMed Central

8 August 2017

Duncan I Jodrell

12

1 reference

Europe PubMed Central

8 August 2017

publication date

23 March 2011

1 reference

Europe PubMed Central

8 August 2017

Cancer Chemotherapy and Pharmacology

1 reference

Europe PubMed Central

8 August 2017

68

1 reference

Europe PubMed Central

8 August 2017

1243-1253

1 reference

Europe PubMed Central

8 August 2017

5

1 reference

Europe PubMed Central

8 August 2017

describes a project that uses

liquid chromatography–mass spectrometry

1 reference

based on heuristic

inferred from title

https://scigraph.springernature.com/pub.10.1007/s00280-011-1613-0

0 references

Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer

1 reference

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Guidelines for the welfare and use of animals in cancer research

1 reference

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Analysis of adenosine phosphates in HepG-2 cell by a HPLC-ESI-MS system with porous graphitic carbon as stationary phase

1 reference

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12 July 2018

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

1 reference

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Dose translation from animal to human studies revisited

1 reference

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12 July 2018

Quantitative 19F MR spectroscopy at 3 T to detect heterogeneous capecitabine metabolism in human liver

1 reference

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12 July 2018

The determination of gemcitabine and 2'-deoxycytidine in human plasma and tissue by APCI tandem mass spectrometry

1 reference

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12 July 2018

Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse

1 reference

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Determination and characterization of organic explosives using porous graphitic carbon and liquid chromatography-atmospheric pressure chemical ionization mass spectrometry

1 reference

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12 July 2018

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

1 reference

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12 July 2018

Tumor uptake and elimination of 2',2'-difluoro-2'-deoxycytidine (gemcitabine) after deoxycytidine kinase gene transfer: correlation with in vivo tumor response.

1 reference

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12 July 2018

Fluorine nuclear magnetic resonance, a privileged tool for metabolic studies of fluoropyrimidine drugs

1 reference

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12 July 2018

Radiation concurrent with gemcitabine for locally advanced head and neck cancer: a phase I trial and intracellular drug incorporation study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215866

12 July 2018

Assessing clinical benefit in the treatment of pancreas cancer: gemcitabine compared to 5-fluorouracil

1 reference

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12 July 2018

Preclinical characteristics of gemcitabine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215866

12 July 2018

Schedule dependence of sensitivity to 2',2'-difluorodeoxycytidine (Gemcitabine) in relation to accumulation and retention of its triphosphate in solid tumour cell lines and solid tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215866

12 July 2018

Tumor trapping of 5-fluorouracil: in vivo 19F NMR spectroscopic pharmacokinetics in tumor-bearing humans and rabbits

1 reference

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12 July 2018

A phase I clinical, plasma, and cellular pharmacology study of gemcitabine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215866

12 July 2018

Simultaneous quantification of 2',2'-difluorodeoxycytidine and 2',2'-difluorodeoxyuridine nucleosides and nucleotides in white blood cells using porous graphitic carbon chromatography coupled with tandem mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215866

26 September 2018

Development of a sensitive and selective LC-MS/MS method for simultaneous determination of gemcitabine and 2,2-difluoro-2-deoxyuridine in human plasma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215866

26 September 2018

Human equilibrative nucleoside transporter 1 and human concentrative nucleoside transporter 3 predict survival after adjuvant gemcitabine therapy in resected pancreatic adenocarcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215866

26 September 2018

Retention studies of 2'-2'-difluorodeoxycytidine and 2'-2'-difluorodeoxyuridine nucleosides and nucleotides on porous graphitic carbon: development of a liquid chromatography-tandem mass spectrometry method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215866

26 September 2018

Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer

1 reference

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Optimized blood sampling with cytidine deaminase inhibitor for improved analysis of capecitabine metabolites

1 reference

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Extensive metabolism and hepatic accumulation of gemcitabine after multiple oral and intravenous administration in mice

1 reference

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19F NMR in vivo spectroscopy reflects the effectiveness of perfusion-enhancing vascular modifiers for improving gemcitabine chemotherapy.

1 reference

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Quantitative analysis of gemcitabine triphosphate in human peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.

1 reference

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Separation and detection of the isomeric equine conjugated estrogens, equilin sulfate and delta8,9-dehydroestrone sulfate, by liquid chromatography--electrospray-mass spectrometry using carbon-coated zirconia and porous graphitic carbon stationary p

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Differential diagnosis of pancreatic tumors using ultrasound contrast imaging.

1 reference

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Measurement of the anticancer agent gemcitabine and its deaminated metabolite at low concentrations in human plasma by liquid chromatography-mass spectrometry

1 reference

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19F-magnetic resonance spectroscopy in patients with liver metastases of colorectal cancer treated with 5-fluorouracil

1 reference

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In vivo monitoring of capecitabine metabolism in human liver by 19fluorine magnetic resonance spectroscopy at 1.5 and 3 Tesla field strength.

1 reference

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Gemcitabine transport in xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters.

1 reference

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Deoxycytidine kinase and deoxycytidine deaminase activities in human tumour xenografts

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of 2',2'-difluorodeoxycytidine (gemcitabine) and formycin B with the Na+-dependent and -independent nucleoside transporters of Ehrlich ascites tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21431415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical phase I and pharmacology study of gemcitabine (2', 2'-difluorodeoxycytidine) administered in a two-weekly schedule

1 reference

https://pubmed.ncbi.nlm.nih.gov/21431415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Validated assay for the simultaneous determination of the anti-cancer agent gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma by high-performance liquid chromatography with tandem mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/21431415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Action of 2',2'-difluorodeoxycytidine on DNA synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21431415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intratumoral pharmacokinetic analysis by 19F-magnetic resonance spectroscopy and cytostatic in vivo activity of gemcitabine (dFdC) in two small cell lung cancer xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/21431415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of the antimetabolite Gemcitabine (2',2'-difluoro-2'-deoxycytidine) and of 2',2'-difluoro-2'-deoxyuridine by 19F nuclear magnetic resonance spectroscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21431415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00280-011-1613-0

1 reference

Europe PubMed Central

8 August 2017

1 reference

Europe PubMed Central

8 August 2017

1 reference

Europe PubMed Central

8 August 2017

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