(Q35559801)

8 August 2017

title

Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus (English)

1 reference

8 August 2017

0 references

4

Michael W Young

1 reference

8 August 2017

A Reum Jang

1

1 reference

8 August 2017

Katarina Moravcevic

series ordinal

2

1 reference

8 August 2017

Lino Saez

series ordinal

3

1 reference

8 August 2017

Amita Sehgal

series ordinal

5

1 reference

8 August 2017

publication date

12 February 2015

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8 August 2017

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8 August 2017

volume

11

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8 August 2017

issue

2

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8 August 2017

page(s)

e1004974

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Creative Commons Attribution 4.0 International

8 August 2017

copyright license

start time

12 February 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila

27 July 2018

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27 July 2018

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Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in new timeless mutant

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

NEMO/NLK phosphorylates PERIOD to initiate a time-delay phosphorylation circuit that sets circadian clock speed

27 July 2018

1 reference

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Nuclear import by karyopherin-βs: recognition and inhibition

27 July 2018

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Two distinct modes of PERIOD recruitment onto dCLOCK reveal a novel role for TIMELESS in circadian transcription.

27 July 2018

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27 July 2018

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Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes

27 July 2018

1 reference

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The nuclear transport machinery as a regulator of Drosophila development

27 July 2018

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27 July 2018

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Light-dependent interactions between the Drosophila circadian clock factors cryptochrome, jetlag, and timeless.

27 July 2018

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TIMELESS is an important mediator of CK2 effects on circadian clock function in vivo

27 July 2018

1 reference

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The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock.

27 July 2018

1 reference

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Drosophila importin alpha1 performs paralog-specific functions essential for gametogenesis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Structural biology of nucleocytoplasmic transport

27 July 2018

1 reference

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An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases

27 July 2018

1 reference

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Classical nuclear localization signals: definition, function, and interaction with importin alpha

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

The HHpred interactive server for protein homology detection and structure prediction

27 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

RNA interference in biology and disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Importin alpha transports CaMKIV to the nucleus without utilizing importin beta

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Karyopherins: from nuclear-transport mediators to nuclear-function regulators

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Importin α: a multipurpose nuclear-transport receptor

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Protein structure prediction and analysis using the Robetta server.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Novel insights into the regulation of the timeless protein.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

A role for casein kinase 2alpha in the Drosophila circadian clock

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Comparison of ARM and HEAT protein repeats

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Biophysical characterization of interactions involving importin-alpha during nuclear import

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

A TIMELESS-independent function for PERIOD proteins in the Drosophila clock

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Differential regulation of circadian pacemaker output by separate clock genes in Drosophila

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Structure of importin-beta bound to the IBB domain of importin-alpha

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

TIMELESS-dependent positive and negative autoregulation in the Drosophila circadian clock

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of beta-catenin

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Regulation of nuclear entry of the Drosophila clock proteins period and timeless.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Block in nuclear localization of period protein by a second clock mutation, timeless

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Template-based protein structure modeling using the RaptorX web server.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

A key temporal delay in the circadian cycle of Drosophila is mediated by a nuclear localization signal in the timeless protein

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Recognition of nuclear targeting signals by Karyopherin-β proteins

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

A hierarchical phosphorylation cascade that regulates the timing of PERIOD nuclear entry reveals novel roles for proline-directed kinases and GSK-3beta/SGG in circadian clocks.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

pGenTHREADER and pDomTHREADER: new methods for improved protein fold recognition and superfamily discrimination

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Molecular mechanism of the nuclear protein import cycle

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

A Novel C-Terminal Domain of Drosophila PERIOD Inhibits dCLOCK:CYCLE-Mediated Transcription

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Patterns of importin-alpha expression during Drosophila spermatogenesis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

The auto-inhibitory function of importin alpha is essential in vivo.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

The Drosophila clock protein Timeless is a member of the Arm/HEAT family.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Sequential nuclear accumulation of the clock proteins period and timeless in the pacemaker neurons of Drosophila melanogaster.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

A search for Drosophila neural precursor genes identifies ran.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Temporally regulated nuclear entry of the Drosophila period protein contributes to the circadian clock.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335507

Quantitative analysis of nuclear localization signal (NLS)-importin alpha interaction through fluorescence depolarization. Evidence for auto-inhibitory regulation of NLS binding.

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25674790

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PGEN.1004974

1 reference

8 August 2017

1 reference

8 August 2017

1 reference