(Q35565981)

8 August 2017

1 reference

title

Pharmacological modulation of Poly(ADP-ribose) polymerase-mediated cell death: exploitation in cancer chemotherapy (English)

1 reference

8 August 2017

Pharmacological Modulation of Poly(ADP-ribose) Polymerase-Mediated Cell Death: Exploitation in Cancer Chemotherapy (English)

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

24 March 2024

1 reference

1 reference

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

24 March 2024

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

24 March 2024

1

Paul A. Nguewa

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14573748

24 March 2024

2

Miguel A. Fuertes

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14573748

24 March 2024

author name string

Carlos Alonso

3

1 reference

8 August 2017

Jose M. Perez

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14573748

24 March 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14573748

24 March 2024

publication date

1 November 2003

1 reference

full work available at URL

8 August 2017

https://syndication.highwire.org/content/doi/10.1124/mol.64.5.1007

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

24 March 2024

published in

Molecular Pharmacology

1 reference

8 August 2017

64

1 reference

8 August 2017

1007-1014

1 reference

8 August 2017

5

1 reference

The nucleus is insulated from large cytosolic calcium ion changes

8 August 2017

1

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures

24 March 2024

2

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells.

24 March 2024

3

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064.

24 March 2024

4

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Physiology and pathophysiology of poly(ADP-ribosyl)ation

24 March 2024

5

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

PARP-1: a regulator of genomic stability linked with mammalian longevity

24 March 2024

6

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

The NAD+ precursors, nicotinic acid and nicotinamide protect cells against apoptosis induced by a multiple stress inducer, deoxycholate.

24 March 2024

7

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

24 March 2024

9

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

24 March 2024

11

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism.

24 March 2024

12

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Poly(ADP-ribose) polymerase: a molecular nick-sensor

24 March 2024

13

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Structure and function of poly(ADP-ribose) polymerase

24 March 2024

14

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo.

24 March 2024

15

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Intra-mitochondrial poly(ADP-ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress

24 March 2024

16

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

24 March 2024

Phosphoinositide kinases

20

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Cisplatin biochemical mechanism of action: from cytotoxicity to induction of cell death through interconnections between apoptotic and necrotic pathways

24 March 2024

21

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Biochemical modulation of Cisplatin mechanisms of action: enhancement of antitumor activity and circumvention of drug resistance

24 March 2024

22

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis

24 March 2024

23

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7.

24 March 2024

24

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Cell death mechanisms and the immune system

24 March 2024

25

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Is cisplatin-induced cell death always produced by apoptosis?

24 March 2024

26

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Mitochondria and apoptosis

24 March 2024

27

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Apoptosis- and necrosis-inducing potential of cladribine, cytarabine, cisplatin, and 5-fluorouracil in vitro: a quantitative pharmacodynamic model.

24 March 2024

28

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Failure of poly(ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis

24 March 2024

30

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

A fast signal-induced activation of Poly(ADP-ribose) polymerase: a novel downstream target of phospholipase c.

24 March 2024

31

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Trypanosoma cruzi: differentiation to metacyclic trypomastigotes in the presence of ADP-ribosyltransferase inhibitors.

24 March 2024

32

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Inhibition of homodimerization of poly(ADP-ribose) polymerase by its C-terminal cleavage products produced during apoptosis

24 March 2024

34

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Molecular and biochemical features of poly (ADP-ribose) metabolism

24 March 2024

36

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

24 March 2024

37

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis

24 March 2024

38

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Inhibition of mitochondrial ATP generation by nitric oxide switches apoptosis to necrosis

24 March 2024

39

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks

24 March 2024

40

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

24 March 2024

Apoptosis in cancer

41

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Role of glutamic acid 988 of human poly-ADP-ribose polymerase in polymer formation. Evidence for active site similarities to the ADP-ribosylating toxins

24 March 2024

42

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

A concomitant ATP-depleting strategy markedly enhances anticancer agent activity

24 March 2024

45

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Poly(ADP-ribose) polymerase: structure-function relationship

24 March 2024

46

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Potential chemotherapeutic activity of 4-iodo-3-nitrobenzamide. Metabolic reduction to the 3-nitroso derivative and induction of cell death in tumor cells in culture

24 March 2024

47

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Modulation of inflammatory arthritis by inhibition of poly(ADP ribose) polymerase

24 March 2024

48

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Apoptosis induction and DNA interstrand cross-link formation by cytotoxic trans-[PtCl2(NH(CH3)2)(NHCH(CH3)2) : cross-linking between d(G) and complementary d(C) within oligonucleotide duplexes

24 March 2024

49

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

24 March 2024

51

102

139

1998

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Apoptosis and necrosis: different execution of the same death

24 March 2024

52

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Apoptosis induced in advanced CD8F1-murine mammary tumors by the combination of PALA, MMPR and 6AN precedes tumor regression and is preceded by ATP depletion

24 March 2024

53

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Induction of tumor cell apoptosis in vivo increases tumor antigen cross-presentation, cross-priming rather than cross-tolerizing host tumor-specific CD8 T cells

24 March 2024

54

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Regulation of cell death: the calcium-apoptosis link

24 March 2024

55

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Apoptosis and necrosis following exposure of U937 cells to increasing concentrations of hydrogen peroxide: the effect of the poly(ADP-ribose)polymerase inhibitor 3-aminobenzamide

24 March 2024

56

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Apoptosis induction and inhibition of H-ras overexpression by novel trans-[PtCl2(isopropylamine)(amine')] complexes

24 March 2024

57

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity

24 March 2024

58

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Parvovirus H-1-induced cell death: influence of intracellular NAD consumption on the regulation of necrosis and apoptosis

24 March 2024

59

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken

24 March 2024

60

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

The mechanism of the elongation and branching reaction of poly(ADP-ribose) polymerase as derived from crystal structures and mutagenesis

24 March 2024

61

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage

24 March 2024

62

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Enhanced polyadenosine diphosphate-ribosylation in cirrhotic liver and carcinoma tissues in patients with hepatocellular carcinoma

24 March 2024

65

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

The carboxyl-terminal domain of human poly(ADP-ribose) polymerase. Overproduction in Escherichia coli, large scale purification, and characterization

24 March 2024

66

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Poly(ADP-ribose) polymerase inhibitors

24 March 2024

67

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

13C and 31P NMR investigation of effect of 6-aminonicotinamide on metabolism of RIF-1 tumor cells in vitro

24 March 2024

68

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Peroxynitrite production, DNA breakage, and poly(ADP-ribose) polymerase activation in a mouse model of oxazolone-induced contact hypersensitivity

24 March 2024

69

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

VP-16-induced nucleotide pool changes and poly(ADP-ribose) synthesis: the role of VP-16 in interphase death

24 March 2024

70

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Poly (ADP-ribose) polymerase inhibitor increases apoptosis and reduces necrosis induced by a DNA minor groove binding methyl sulfonate ester

24 March 2024

71

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors.

24 March 2024

72

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

24 March 2024

73

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate

24 March 2024

74

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

DNA damage and cytotoxicity induced by beta-lapachone: relation to poly(ADP-ribose) polymerase inhibition

24 March 2024

75

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Characterization of poly(ADP-ribose)polymerase from Crithidia fasciculata: enzyme inhibition by beta-lapachone

24 March 2024

76

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

The therapeutic potential of poly(ADP-ribose) polymerase inhibitors

24 March 2024

77

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

ADP-ribosylation of nuclear proteins in normal lymphocytes and in low-grade malignant non-Hodgkin lymphoma cells.

24 March 2024

79

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

Apoptosis: cell death in tissue regulation

24 March 2024

80

1 reference

https://api.crossref.org/works/10.1124/MOL.64.5.1007

24 March 2024

Identifiers

1 reference

8 August 2017

1 reference