(Q35567292)

8 August 2017

1 reference

title

Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy (English)

1 reference

antineoplastic resistance

8 August 2017

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14576856

24 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206952

24 March 2024

4

Stephen A Baldwin

1 reference

8 August 2017

5

John Mackey

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14576856

24 March 2024

author name string

Sambasivarao Damaraju

2

1 reference

8 August 2017

Vijaya L. Damaraju

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14576856

24 March 2024

James D. Young

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14576856

24 March 2024

Michael B. Sawyer

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14576856

24 March 2024

Carol E. Cass

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14576856

24 March 2024

language of work or name

English

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publication date

1 October 2003

1 reference

8 August 2017

20 October 2003

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14576856

full work available at URL

24 March 2024

https://www.nature.com/articles/1206952.pdf

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206952

https://www.nature.com/articles/1206952

24 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206952

24 March 2024

1 reference

8 August 2017

22

1 reference

8 August 2017

7524-7536

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8 August 2017

47

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.onc.1206952

8 August 2017

0 references

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Role of organic cation transporters in the renal secretion of nucleosides.

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Fludarabine phosphate: a synthetic purine antimetabolite with significant activity against lymphoid malignancies

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PKC regulation of the human equilibrative nucleoside transporter, hENT1.

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Assignment of the human equilibrative nucleoside transporter (hENT1) to 6p21.1-p21.2.

21 January 2018

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Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line

21 January 2018

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Effects of phorbol esters and secretagogues on nitrobenzylthioinosine binding to nucleoside transporters and nucleoside uptake in cultured chromaffin cells.

21 January 2018

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Long term regulation of nucleoside transport by thyroid hormone (T3) in cultured chromaffin cells

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Characterization of a novel Na+-dependent, guanosine-specific, nitrobenzylthioinosine-sensitive transporter in acute promyelocytic leukemia cells

21 January 2018

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In vivo mechanisms of resistance to cytarabine in acute myeloid leukaemia.

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Es nucleoside transporter content of acute leukemia cells: role in cell sensitivity to cytarabine (araC).

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Troxacitabine, a novel dioxolane nucleoside analog, has activity in patients with advanced leukemia

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Randomized phase I/II study of troxacitabine combined with cytarabine, idarubicin, or topotecan in patients with refractory myeloid leukemias.

21 January 2018

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Differential transport of cytosine-containing nucleosides by recombinant human concentrative nucleoside transporter protein hCNT1

21 January 2018

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Nucleoside and nucleobase transport systems of mammalian cells

21 January 2018

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Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs

21 January 2018

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Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta

21 January 2018

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Equilibrative and concentrative nucleoside transporters mediate influx of extracellular cyclic ADP-ribose into 3T3 murine fibroblasts

21 January 2018

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Nucleoside transport in brush border membrane vesicles from human kidney

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Substrate selectivity, potential sensitivity and stoichiometry of Na(+)-nucleoside transport in brush border membrane vesicles from human kidney

21 January 2018

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Expression of a human renal sodium nucleoside cotransporter in Xenopus laevis oocytes

21 January 2018

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Genotype frequencies of 50 polymorphisms for 241 Japanese non-cancer patients

21 January 2018

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Cloning of a novel isoform of the mouse NBMPR-sensitive equilibrative nucleoside transporter (ENT1) lacking a putative phosphorylation site

21 January 2018

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Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study

21 January 2018

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21 January 2018

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The ENT family of eukaryote nucleoside and nucleobase transporters: recent advances in the investigation of structure/function relationships and the identification of novel isoforms

21 January 2018

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Catalog of 46 single-nucleotide polymorphisms (SNPs) in the microsomal glutathione S-transferase 1 (MGST1) gene

21 January 2018

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Distinct regional distribution of human equilibrative nucleoside transporter proteins 1 and 2 (hENT1 and hENT2) in the central nervous system

21 January 2018

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Effect of cellular differentiation on nucleoside transport in human neuroblastoma cells.

21 January 2018

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New antimetabolites in cancer chemotherapy and their clinical impact

21 January 2018

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Decrease in equilibrative uridine transport during monocytic differentiation of HL-60 leukaemia: involvement of protein kinase C.

21 January 2018

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Induction of the differentiation of HL-60 cells by phorbol 12-myristate 13-acetate activates a Na(+)-dependent uridine-transport system. Involvement of protein kinase C.

21 January 2018

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Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2

21 January 2018

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Correlation of nucleoside and nucleobase transporter gene expression with antimetabolite drug cytotoxicity

21 January 2018

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Human intestinal es nucleoside transporter: molecular characterization and nucleoside inhibitory profiles

21 January 2018

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Gemcitabine transport in xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters.

21 January 2018

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The biological significance of purine salvage

21 January 2018

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Functional characterization in yeast of genetic variants in the human equilibrative nucleoside transporter, ENT1

21 January 2018

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Hypoxanthine enters human vascular endothelial cells (ECV 304) via the nitrobenzylthioinosine-insensitive equilibrative nucleoside transporter

21 January 2018

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Inhibition of nitrobenzylthioinosine-sensitive adenosine transport by elevated D-glucose involves activation of P2Y2 purinoceptors in human umbilical vein endothelial cells.

21 January 2018

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Differential expression of human nucleoside transporters in normal and tumor tissue

21 January 2018

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Purine analogues kill resting lymphocytes by p53-dependent and -independent mechanisms.

21 January 2018

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The effect of p53 dysfunction on purine analogue cytotoxicity in chronic lymphocytic leukaemia.

21 January 2018

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Recent molecular advances in studies of the concentrative Na+-dependent nucleoside transporter (CNT) family: identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosi

21 January 2018

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Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib)

21 January 2018

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Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine

21 January 2018

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A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms

21 January 2018

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Comparative genomic analysis of equilibrative nucleoside transporters suggests conserved protein structure despite limited sequence identity

21 January 2018

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Adenosine receptor activation potentiates phosphoinositide hydrolysis and arachidonic acid release in DDT1-MF2 cells: putative interrelations

21 January 2018

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Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer

21 January 2018

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A single glycine mutation in the equilibrative nucleoside transporter gene, hENT1, alters nucleoside transport activity and sensitivity to nitrobenzylthioinosine

21 January 2018

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Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology, and pharmacology

21 January 2018

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Effects of uridine on the growth and differentiation of HL-60 leukemia cells

21 January 2018

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Macrophages require different nucleoside transport systems for proliferation and activation

21 January 2018

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Phase II study of single-agent gemcitabine in previously untreated patients with metastatic urothelial cancer

21 January 2018

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Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia

21 January 2018

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Maneuvering in the complex path from genotype to phenotype

21 January 2018

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Topology of a human equilibrative, nitrobenzylthioinosine (NBMPR)-sensitive nucleoside transporter (hENT1) implicated in the cellular uptake of adenosine and anti-cancer drugs

21 January 2018

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Equilibrative nucleoside transporters: mapping regions of interaction for the substrate analogue nitrobenzylthioinosine (NBMPR) using rat chimeric proteins

21 January 2018

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Chimeric constructs between human and rat equilibrative nucleoside transporters (hENT1 and rENT1) reveal hENT1 structural domains interacting with coronary vasoactive drugs

21 January 2018

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Randomised, phase II trial comparing oral capecitabine (Xeloda) with paclitaxel in patients with metastatic/advanced breast cancer pretreated with anthracyclines.

21 January 2018

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Phase II study of troxacitabine (BCH-4556) in patients with advanced and/or metastatic renal cell carcinoma: a trial of the National Cancer Institute of Canada-Clinical Trials Group

21 January 2018

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Comparison of the interaction of uridine, cytidine, and other pyrimidine nucleoside analogues with recombinant human equilibrative nucleoside transporter 2 (hENT2) produced in Saccharomyces cerevisiae

21 January 2018

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Mutation of residue 33 of human equilibrative nucleoside transporters 1 and 2 alters sensitivity to inhibition of transport by dilazep and dipyridamole

21 January 2018

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Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study

21 January 2018

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Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters, ENT1 and ENT2, stably expressed in nucleoside transporter-deficient PK15 cells. Ent2 exhibits a low affinity for guanosine and cytidine but a high affinity

21 January 2018

1 reference

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Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

21 January 2018

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Molecular cloning and functional characterization of nitrobenzylthioinosine (NBMPR)-sensitive (es) and NBMPR-insensitive (ei) equilibrative nucleoside transporter proteins (rENT1 and rENT2) from rat tissues

21 January 2018

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Transport of antiviral 3'-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzylthioinosine (NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced in Xenopus oocytes

21 January 2018

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Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation

21 January 2018

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2'-Deoxy-2'-methylenecytidine and 2'-deoxy-2',2'-difluorocytidine 5'-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase

21 January 2018

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7 January 2021

Primary therapy of Waldenström's macroglobulinemia with 2-chlorodeoxyadenosine

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7 January 2021

Continuous infusions of arabinosyl cytosine in patients with neoplastic disease

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7 January 2021

Nucleoside transport and its significance for anticancer drug resistance

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7 January 2021

Regulation of nucleoside transport by lipopolysaccharide, phorbol esters, and tumor necrosis factor-alpha in human B-lymphocytes

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7 January 2021

Lipopolysaccharide-induced apoptosis of macrophages determines the up-regulation of concentrative nucleoside transporters Cnt1 and Cnt2 through tumor necrosis factor-alpha-dependent and -independent mechanisms

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7 January 2021

Cytosine arabinoside transport by human leukaemic cells

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7 January 2021

The role of membrane transporters in cellular resistance to anticancer nucleoside drugs.

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9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-monophosphate pharmacokinetics in plasma and tumor cells of patients with relapsed leukemia and lymphoma

24 March 2024

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Steroid-induced inhibition of adenosine transport in cultured chromaffin cells

24 March 2024

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Accumulation of leukemic cell DNA strand breaks with adriamycin and cytosine arabinoside

24 March 2024

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Acquisition of human concentrative nucleoside transporter 2 (hcnt2) activity by gene transfer confers sensitivity to fluoropyrimidine nucleosides in drug-resistant leukemia cells.

24 March 2024

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Ontogenic and longitudinal activity of Na(+)-nucleoside transporters in the human intestine

24 March 2024

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Sodium-dependent nucleoside transport in the human intestinal brush-border membrane

24 March 2024

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Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1)

24 March 2024

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Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization

24 March 2024

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24 March 2024

Identifiers

1 reference

8 August 2017

1 reference