(Q35570825)

8 August 2017

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title

Lysosomes and brain aging in mammals (English)

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8 August 2017

Gary Lynch

1

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8 August 2017

Xiaoning Bi

series ordinal

2

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8 August 2017

publication date

1 November 2003

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8 August 2017

published in

Neurochemical Research

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8 August 2017

volume

28

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8 August 2017

issue

11

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8 August 2017

page(s)

1725-1734

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Suppression of cathepsins B and L causes a proliferation of lysosomes and the formation of meganeurites in hippocampus.

8 August 2017

cites work

1 reference

12 December 2020

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Stable depression of potentiated synaptic responses in the hippocampus with 1-5 Hz stimulation

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Taxonomic differences in the mammalian life span-body weight relationship and the problem of brain weight

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12 December 2020

Fractal analysis of senile plaque observed in various animal species

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12 December 2020

Lysosomal dysfunction results in lamina-specific meganeurite formation but not apoptosis in frontal cortex

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Beta-amyloid accumulation in aged canine brain: a model of early plaque formation in Alzheimer's disease

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12 December 2020

Stable hippocampal long-term potentiation elicited by 'theta' pattern stimulation

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12 December 2020

Cytosolic proteolysis of tau by cathepsin D in hippocampus following suppression of cathepsins B and L.

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12 December 2020

Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease

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12 December 2020

Induction and experience-dependent consolidation of stable long-term potentiation lasting months in the hippocampus.

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12 December 2020

Region-specific age at onset of beta-amyloid in dogs

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Increase in cathepsin D activity in rat brain in aging

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12 December 2020

Regionally selective changes in brain lysosomes occur in the transition from young adulthood to middle age in rats

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12 December 2020

Body size and metabolic rate

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12 December 2020

Energy metabolism and body size. I. Is the 0.75 mass exponent of Kleiber's equation a statistical artifact?

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12 December 2020

beta-Amyloid (A beta) deposition in the brains of aged orangutans.

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12 December 2020

Anomalous accumulation of tau and ubiquitin immunoreactivities in rat brain caused by protease inhibition and by normal aging: a clue to PHF pathogenesis?

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12 December 2020

Mitochondrial free radical production and aging in mammals and birds

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12 December 2020

Induction of beta-amyloid-containing polypeptides in hippocampus: evidence for a concomitant loss of synaptic proteins and interactions with an excitotoxin

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12 December 2020

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12 December 2020

Neuropathological stageing of Alzheimer-related changes

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12 December 2020

A comparative study of soluble calcium-dependent proteolytic activity in brain

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12 December 2020

Rapid induction of intraneuronal neurofibrillary tangles in apolipoprotein E-deficient mice

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12 December 2020

Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs

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12 December 2020

Distribution, progression and chemical composition of cortical amyloid-beta deposits in aged rhesus monkeys: similarities to the human

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12 December 2020

Frequency of stages of Alzheimer-related lesions in different age categories

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12 December 2020

Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease

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12 December 2020

Cell counts in the primate cerebral cortex.

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12 December 2020

Abnormally phosphorylated tau protein related to the formation of neurofibrillary tangles and neuropil threads in the cerebral cortex of sheep and goat

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12 December 2020

Amyloid-beta deposits in the cerebral cortex of the aged common marmoset (Callithrix jacchus): incidence and chemical composition

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12 December 2020

Lysosomal protease inhibitors induce meganeurites and tangle-like structures in entorhinohippocampal regions vulnerable to Alzheimer's disease

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12 December 2020

Quantitative decrease in synaptophysin message expression and increase in cathepsin D message expression in Alzheimer disease neurons containing neurofibrillary tangles

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12 December 2020

The biologic clock: the mitochondria?

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12 December 2020

Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus.

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12 December 2020

Spatial patterns of mammalian brain aging: distribution of cathepsin D-immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease

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12 December 2020

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12 December 2020

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12 December 2020

Senile plaques in an aged western lowland gorilla

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12 December 2020

Spindle-shaped appendages of IIIab-pyramids filled with lipofuscin: A striking pathological change of the senescent human isocortex

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12 December 2020

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12 December 2020

Elevated levels of the endosomal-lysosomal proteinase cathepsin D in cerebrospinal fluid in Alzheimer disease.

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12 December 2020

Lysosome instability in aged rat brain

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12 December 2020

Increased expression of cathepsins E and D in neurons of the aged rat brain and their colocalization with lipofuscin and carboxy-terminal fragments of Alzheimer amyloid precursor protein.

1 reference

12 December 2020

Neuropathology of preclinical and clinical late-onset Alzheimer's disease

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12 December 2020

Principles underlying mammalian neocortical scaling.

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12 December 2020

Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment

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12 December 2020

Age-dependent change in activities of lysosomal enzymes in rat brain

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12 December 2020

Brain weight and life-span in primate species

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12 December 2020

Inhibitors of lysosomal enzymes: accumulation of lipofuscin-like dense bodies in the brain

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12 December 2020

Energy metabolism, brain size and longevity in mammals

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12 December 2020

Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction

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12 December 2020

Identifiers

DOI

10.1023/A:1026069223763

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Dimensions Publication ID

8 August 2017

1030204535

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