(Q41727024)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10737603%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

title

Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus (English)

1 reference

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5 November 2019

5

1 reference

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5 November 2019

author name string

X Bi

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10737603%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

T S Haque

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10737603%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

J Zhou

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10737603%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

A G Skillman

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10737603%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

C E Lee

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10737603%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

I D Kuntz

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10737603%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

J A Ellman

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10737603%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

G Lynch

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10737603%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

language of work or name

English

0 references

publication date

1 April 2000

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10737603%20AND%20SRC:MED&resulttype=core&format=json

Journal of Neurochemistry

5 November 2019

number of pages

9

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10737603%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

volume

74

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10737603%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

issue

4

1 reference

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5 November 2019

page(s)

1469-1477

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10737603%20AND%20SRC:MED&resulttype=core&format=json

Paired helical filament tau (PHFtau) in Niemann-Pick type C disease is similar to PHFtau in Alzheimer's disease

5 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Long-term hippocampal slices: a model system for investigating synaptic mechanisms and pathologic processes

21 January 2018

1 reference

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Induction of beta-amyloid-containing polypeptides in hippocampus: evidence for a concomitant loss of synaptic proteins and interactions with an excitotoxin

21 January 2018

1 reference

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Amyloid beta protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein

21 January 2018

1 reference

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Glycogen synthase kinase 3 alteration in Alzheimer disease is related to neurofibrillary tangle formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Selective suppression of cathepsin L results from elevations in lysosomal pH and is followed by proteolysis of tau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Lysosomal protease inhibitors induce meganeurites and tangle-like structures in entorhinohippocampal regions vulnerable to Alzheimer's disease

21 January 2018

1 reference

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Pigmentoarchitectonic pathology of the isocortex in juvenile neuronal ceroid-lipofuscinosis: Axonal enlargements in layer IIIab and cell loss in layer V

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Cathepsin D displays in vitro beta-secretase-like specificity.

21 January 2018

1 reference

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Isolation of procathepsin D from mature cathepsin D by pepstatin affinity chromatography. Autocatalytic proteolysis of the zymogen form of the enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Processing of the Pre‐β‐amyloid Protein by Cathepsin d is Enhanced by a Familial Alzheimer's Disease Mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Normal Processing of the Alzheimer's Disease Amyloid β Protein Precursor Generates Potentially Amyloidogenic Carboxyl‐Terminal Derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

p42 map kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1Implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Cathepsin D is involved in the clearance of Alzheimer's beta-amyloid protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Potent, low-molecular-weight non-peptide inhibitors of malarial aspartyl protease plasmepsin II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Lysosomal enzyme precursors in human fibroblasts. Activation of cathepsin D precursor in vitro and activity of beta-hexosaminidase A precursor towards ganglioside GM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Beta-amyloid increases cathepsin D levels in hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Structure-based design and combinatorial chemistry yield low nanomolar inhibitors of cathepsin D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Synthetic approaches to continuous assays of retroviral proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Automated site-directed drug design using molecular lattices

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

A possible role for cathepsins D, E, and B in the processing of beta-amyloid precursor protein in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

The topographic distribution of senile plaques and neurofibrillary tangles in the brains of non-demented persons of different ages

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Time course of synaptic development in hippocampal organotypic cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

A modified form of microtubule-associated tau protein is the main component of paired helical filaments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Characterization of tau protein present in microtubules and paired helical filaments of Alzheimer's disease patient's brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

An ultrastructural and immunohistochemical study of PC12 cells during apoptosis induced by serum deprivation with special reference to autophagy and lysosomal cathepsins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Expression of protein phosphatases (PP-1, PP-2A, PP-2B and PTP-1B) and protein kinases (MAP kinase and P34cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals.

21 January 2018

1 reference

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Pick's disease: hyperphosphorylated tau protein segregates to the somatoaxonal compartment.

21 January 2018

1 reference

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Distortion of neuronal geometry and formation of aberrant synapses in neuronal storage disease

21 January 2018

1 reference

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Inhibition of early but not late proteolytic processing events leads to the missorting and oversecretion of precursor forms of lysosomal enzymes in Dictyostelium discoideum

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

BUILDER v.2: improving the chemistry of a de novo design strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

The inhibition of macrophage protein turnover by a selective inhibitor of thiol proteinases

21 January 2018

1 reference

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A simple method for organotypic cultures of nervous tissue

21 January 2018

1 reference

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Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

21 January 2018

1 reference

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Neuropathology of preclinical and clinical late-onset Alzheimer's disease.

21 January 2018

1 reference

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Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X

Lysosomal dysfunction results in lamina-specific meganeurite formation but not apoptosis in frontal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0741469.X