(Q35578023)

English

Recent advances using FcRn overexpression in transgenic animals to overcome impediments of standard antibody technologies to improve the generation of specific antibodies.

scientific article published on September 2011

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22048692%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Recent advances using FcRn overexpression in transgenic animals to overcome impediments of standard antibody technologies to improve the generation of specific antibodies (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22048692%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

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Imre Kacskovics

1

1 reference

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15 January 2020

3

1 reference

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15 January 2020

author name string

Judit Cervenak

2

1 reference

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15 January 2020

Richard A Goldsby

4

1 reference

Europe PubMed Central

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15 January 2020

John E Butler

5

1 reference

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15 January 2020

language of work or name

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publication date

1 September 2011

1 reference

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15 January 2020

Monoclonal Antibodies

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22048692%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22048692%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

5

1 reference

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15 January 2020

431-439

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22048692%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Beyond natural antibodies: the power of in vitro display technologies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Transgenic expression of bovine neonatal Fc receptor in mice boosts immune response and improves hybridoma production efficiency without any sign of autoimmunity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

FcRn overexpression in mice results in potent humoral response against weakly immunogenic antigen.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Development of self-reactive germinal center B cells and plasma cells in autoimmune Fc gammaRIIB-deficient mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

CCR7 is involved in the migration of neutrophils to lymph nodes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Neonatal Fc receptor: from immunity to therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Clinical ramifications of the MHC family Fc receptor FcRn

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Potent high-affinity antibodies for treatment and prophylaxis of respiratory syncytial virus derived from B cells of infected patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Chapter 4: Multitasking by exploitation of intracellular transport functions the many faces of FcRn.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Antibody recognition of a highly conserved influenza virus epitope

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Targeting the neonatal fc receptor for antigen delivery using engineered fc fragments.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

The MHC class II-associated invariant chain interacts with the neonatal Fc gamma receptor and modulates its trafficking to endosomal/lysosomal compartments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Dependence of antibody-mediated presentation of antigen on FcRn

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

NF-kappaB signaling regulates functional expression of the MHC class I-related neonatal Fc receptor for IgG via intronic binding sequences.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

FcRn: the neonatal Fc receptor comes of age.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

A microengraving method for rapid selection of single cells producing antigen-specific antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

THE METABOLISM OF NORMAL PLASMA PROTEINS AND GAMMA-MYELOMA PROTEIN IN MICE BEARING PLASMA-CELL TUMORS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Potent antibody therapeutics by design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Pharmacokinetic and pharmacodynamic effects of high-dose monoclonal antibody therapy in a rat model of immune thrombocytopenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

How antibodies act as natural adjuvants.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Development of antibody-targeted vaccines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

THE CATABOLISM OF HOMOLOGOUS AND HETEROLOGOUS 7S GAMMA GLOBULIN FRAGMENTS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

FACTORS CONTROLLING SERUM γ-GLOBULIN CONCENTRATION

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Redistribution of the sheep neonatal Fc receptor in the mammary gland around the time of parturition in ewes and its localization in the small intestine of neonatal lambs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Cloning and characterization of the bovine MHC class I-like Fc receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Identification and function of neonatal Fc receptor in mammary gland of lactating mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Evaluation of Bcl-2/B cell transgenic mice (B6) for hybridoma production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Antiviral immune responses of lymphocytic choriomeningitis virus-infected mice lacking CD8+ T lymphocytes because of disruption of the beta 2-microglobulin gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Requirement for a beta 2-microglobulin-associated Fc receptor for acquisition of maternal IgG by fetal and neonatal mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Receptor-mediated transport of IgG

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Early stages of intestinal absorption of specific antibiodies in the newborn. An ultrastructural, cytochemical, and immunological study in the pig, rat, and rabbit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

The mechanism of intestinal uptake and transcellular transport of IgG in the neonatal rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Metabolism of immunoglobulins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Enhancement of IgG anti-carrier responses by IgG2 anti-hapten antibodies in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

An Fc receptor structurally related to MHC class I antigens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

12 July 2018

The neonatal FcR-mediated presentation of immune-complexed antigen is associated with endosomal and phagosomal pH and antigen stability in macrophages and dendritic cells.

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.17023

21 January 2018

Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.17023

21 January 2018

Position independent and copy-number-related expression of the bovine neonatal Fc receptor alpha-chain in transgenic mice carrying a 102 kb BAC genomic fragment.

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.17023

21 January 2018

GAMMA GLOBULIN TURNOVER IN RABBITS BEFORE AND DURING HYPERIMMUNIZATION

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.17023

21 January 2018

The neonatal Fc receptor (FcRn) is expressed in the bovine lung.

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.17023

21 January 2018

Immune complex-mediated enhancement of secondary antibody responses.

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.17023

21 January 2018

Identification of memory B cells using a novel transgenic mouse model.

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.17023

21 January 2018

A rapid and efficient single-cell manipulation method for screening antigen-specific antibody-secreting cells from human peripheral blood.

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.17023

21 January 2018

The generation of memory cells. IV. Immunization with antigen-antibody complexes accelerates the development of B-memory cells, the formation of germinal centres and the maturation of antibody affinity in the secondary response.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225847

26 September 2018

Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.17023

21 January 2018

A Theoretical Model of γ-Globulin Catabolism

1 reference

https://api.crossref.org/works/10.4161%2FMABS.3.5.17023

21 January 2018

FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22048692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neonatal FcR Overexpression Boosts Humoral Immune Response in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22048692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/22048692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22048692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved generation of catalytic antibodies by MRL/MPJ-lpr/lpr autoimmune mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22048692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early and enhanced germinal center formation and antibody responses in mice after primary stimulation with antigen-isologous antibody complexes as compared with antigen alone

1 reference

https://pubmed.ncbi.nlm.nih.gov/22048692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic susceptibility to systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/22048692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta 2-microglobulin-deficient mice are protected from hypergammaglobulinemia and have defective antibody responses because of increased IgG catabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22048692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloned transchromosomic calves producing human immunoglobulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22048692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An elegant defense: how neutrophils shape the immune response

1 reference

https://pubmed.ncbi.nlm.nih.gov/22048692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting weak antigens to CD64 elicits potent humoral responses in human CD64 transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22048692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RELATIONSHIP BETWEEN GAMMA-GLOBULIN METABOLISM AND LOW SERUM GAMMA-GLOBULIN IN GERMFREE MICE

1 reference

https://pubmed.ncbi.nlm.nih.gov/22048692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of immune responses by CD8 cells. II. Qa-1 on activated B cells stimulates CD8 cell suppression of T helper 2 responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/22048692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and characterization of an Fc receptor from neonatal rat small intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22048692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated autoantibody clearance by intravenous immunoglobulin therapy: studies in experimental models to determine the magnitude and time course of the effect

1 reference

https://pubmed.ncbi.nlm.nih.gov/22048692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interference by human and bovine serum and serum protein fractions with the absorption of antibodies by suckling rats and mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22048692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presence of neutrophil-bearing antigen in lymphoid organs of immune mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22048692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FcRn mediates elongated serum half-life of human IgG in cattle

1 reference

https://pubmed.ncbi.nlm.nih.gov/22048692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progression of lupus-like disease drives the appearance of complement-activating IgG antibodies in MRL/lpr mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22048692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Over-expression of the bovine FcRn in the mammary gland results in increased IgG levels in both milk and serum of transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22048692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4161/MABS.3.5.17023

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22048692%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22048692%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22048692%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

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