(Q34754673)

4 August 2017

title

Clinical ramifications of the MHC family Fc receptor FcRn (English)

1 reference

4 August 2017

Derry C Roopenian

1

1 reference

4 August 2017

Victor Z Sun

series ordinal

2

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4 August 2017

publication date

17 September 2010

1 reference

Journal of Clinical Immunology

4 August 2017

published in

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4 August 2017

volume

30

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4 August 2017

issue

6

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4 August 2017

page(s)

790-797

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Enhanced antibody half-life improves in vivo activity

4 August 2017

cites work

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7 July 2018

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Chapter 4: Multitasking by exploitation of intracellular transport functions the many faces of FcRn.

7 July 2018

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The versatile MHC class I-related FcRn protects IgG and albumin from degradation: implications for development of new diagnostics and therapeutics.

7 July 2018

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An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice.

7 July 2018

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Renal FcRn reclaims albumin but facilitates elimination of IgG.

7 July 2018

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The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity

7 July 2018

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Role of Fc Receptors as a therapeutic target

7 July 2018

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Structural characterization of a human Fc fragment engineered for extended serum half-life

7 July 2018

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Analyses of the recycling receptor, FcRn, in live cells reveal novel pathways for lysosomal delivery.

7 July 2018

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Dystrophia myotonia: why focus on foci?

7 July 2018

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Molecular engineering and design of therapeutic antibodies

7 July 2018

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Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

FcRn: the neonatal Fc receptor comes of age.

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies

7 July 2018

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Kinetics of FcRn-mediated recycling of IgG and albumin in human: pathophysiology and therapeutic implications using a simplified mechanism-based model

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Perspective-- FcRn transports albumin: relevance to immunology and medicine

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

THE METABOLISM OF NORMAL PLASMA PROTEINS AND GAMMA-MYELOMA PROTEIN IN MICE BEARING PLASMA-CELL TUMORS

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Characterization of basolateral-targeting signals in the neonatal Fc receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Mechanisms of intravenous immunoglobulin action in immune thrombocytopenic purpura

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

From sorting endosomes to exocytosis: association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Engineered human IgG antibodies with longer serum half-lives in primates

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Generation of mutated variants of the human form of the MHC class I-related receptor, FcRn, with increased affinity for mouse immunoglobulin G.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

IgG transcytosis and recycling by FcRn expressed in MDCK cells reveals ligand-induced redistribution

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Does (CUG)n repeat in DMPK mRNA 'paint' chromosome 19 to suppress distant genes to create the diverse phenotype of myotonic dystrophy?: A new hypothesis of long-range cis autosomal inactivation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Tryptophan- and dileucine-based endocytosis signals in the neonatal Fc receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,)

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Multiple roles for the major histocompatibility complex class I- related receptor FcRn

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Mice deficient in Six5 develop cataracts: implications for myotonic dystrophy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Bidirectional transcytosis of IgG by the rat neonatal Fc receptor expressed in a rat kidney cell line: a system to study protein transport across epithelia.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Structural basis of pH-dependent antibody binding by the neonatal Fc receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Increasing the serum persistence of an IgG fragment by random mutagenesis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Fc receptors and their interactions with immunoglobulins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

The structure and evolution of FcRn

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Crystal structure of the complex of rat neonatal Fc receptor with Fc

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Metabolism of immunoglobulins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Accelerated breakdown of immunoglobulin G (IgG) in myotonic dystrophy: a hereditary error of immunoglobulin catabolism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Immunoglobulin levels in dystrophia myotonica

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Crystal structure at 2.2 A resolution of the MHC-related neonatal Fc receptor.

7 July 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10875-010-9458-6

Albumin turnover: FcRn-mediated recycling saves as much albumin from degradation as the liver produces

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10875-010-9458-6

Albumin binding to FcRn: distinct from the FcRn-IgG interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10875-010-9458-6

The conserved histidine 166 residue of the human neonatal Fc receptor heavy chain is critical for the pH-dependent binding to albumin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10875-010-9458-6

Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10875-010-9458-6

High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10875-010-9458-6

Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10875-010-9458-6

Quantitative methods for developing Fc mutants with extended half-lives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10875-010-9458-6

Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10875-010-9458-6

An engineered human IgG1 antibody with longer serum half-life.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10875-010-9458-6

Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10875-010-9458-6

A variable number of tandem repeats polymorphism influences the transcriptional activity of the neonatal Fc receptor alpha-chain promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10875-010-9458-6

Association between polymorphisms in the FCGRT gene and lupus nephritis in Chinese patients.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

Expression of the neonatal Fc receptor (FcRn) in the bovine mammary gland.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069705

IgG transport across mucosal barriers by neonatal Fc receptor for IgG and mucosal immunity

26 October 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10875-010-9458-6

Association of FcRn Heavy Chain Encoding Gene (FCGRT) Polymorphisms with IgG Content in Bovine Colostrum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10875-010-9458-6

A Theoretical Model of γ-Globulin Catabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10875-010-9458-6

Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy

21 January 2018

1 reference

12 December 2020

1 reference

12 December 2020

No association of FCRN promoter VNTR polymorphism with the rate of maternal-fetal IgG transfer

1 reference

12 December 2020

Beta 2-microglobulin-deficient mice are protected from hypergammaglobulinemia and have defective antibody responses because of increased IgG catabolism

1 reference

12 December 2020

Human FcRn transgenic mice for pharmacokinetic evaluation of therapeutic antibodies

1 reference

12 December 2020

A study of gamma globulins in dystrophia myotonica

1 reference

12 December 2020

Lack of correlation between the reduction of serum immunoglobulin concentration and the CTG repeat expansion in patients with type 1 dystrophia [correction of Dystrofia] myotonica

1 reference

12 December 2020

10.1007/S10875-010-9458-6

Identifiers

DOI

1 reference

Dimensions Publication ID

4 August 2017

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4 August 2017

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