(Q35579292)

9 August 2017

title

MicroRNA-221 inhibits autophagy and promotes heart failure by modulating the p27/CDK2/mTOR axis (English)

1 reference

9 August 2017

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M Su

1

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9 August 2017

J Wang

2

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9 August 2017

C Wang

3

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9 August 2017

X Wang

4

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9 August 2017

W Dong

5

1 reference

9 August 2017

W Qiu

6

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9 August 2017

Y Wang

7

1 reference

9 August 2017

X Zhao

8

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9 August 2017

Y Zou

9

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9 August 2017

L Song

10

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9 August 2017

L Zhang

11

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9 August 2017

R Hui

12

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9 August 2017

language of work or name

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14 November 2014

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Cell Death & Differentiation

9 August 2017

published in

1 reference

9 August 2017

volume

22

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9 August 2017

issue

6

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9 August 2017

page(s)

986-999

1 reference

https://scigraph.springernature.com/pub.10.1038/cdd.2014.187

9 August 2017

exact match

0 references

cites work

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Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure

27 July 2018

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TNNI3K, a cardiac-specific kinase, promotes physiological cardiac hypertrophy in transgenic mice

27 July 2018

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Cardiomyocyte-specific deletion of endothelin receptor A rescues aging-associated cardiac hypertrophy and contractile dysfunction: role of autophagy

27 July 2018

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27 July 2018

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The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy.

27 July 2018

1 reference

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MicroRNA-350 induces pathological heart hypertrophy by repressing both p38 and JNK pathways

27 July 2018

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Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation

27 July 2018

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27 July 2018

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MicroRNA-24 regulates cardiac fibrosis after myocardial infarction

27 July 2018

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MicroRNAs and cardiovascular diseases

27 July 2018

1 reference

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

27 July 2018

1 reference

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27 July 2018

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The RB-E2F1 pathway regulates autophagy.

27 July 2018

1 reference

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MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

27 July 2018

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MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice.

27 July 2018

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Akt-dependent and -independent mechanisms of mTOR regulation in cancer

27 July 2018

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

Cardiac autophagy is a maladaptive response to hemodynamic stress

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

MicroRNA-133 controls cardiac hypertrophy

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

Control of translation and mRNA degradation by miRNAs and siRNAs

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

The LKB1 tumor suppressor negatively regulates mTOR signaling

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

Downregulation of cyclin-dependent kinase inhibitors p21 and p27 in pressure-overload hypertrophy

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

MiR-221 promotes cardiac hypertrophy in vitro through the modulation of p27 expression.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

Development by self-digestion: molecular mechanisms and biological functions of autophagy

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

TSC2 mediates cellular energy response to control cell growth and survival

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

Cyclin-dependent kinase inhibitor expression in human heart failure. A comparison with fetal development.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423182

Protein kinase CK2 links extracellular growth factor signaling with the control of p27Kip1 stability in the heart

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FCDD.2014.187

Down-regulation of p27Kip1 promotes cell proliferation of rat neonatal cardiomyocytes induced by nuclear expression of cyclin D1 and CDK4. Evidence for impaired Skp2-dependent degradation of p27 in terminal differentiation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25394488

12 December 2020

inferred from PubMed ID database lookup

The PTPN11 loss-of-function mutation Q510E-Shp2 causes hypertrophic cardiomyopathy by dysregulating mTOR signaling

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25394488

12 December 2020

inferred from PubMed ID database lookup

Inhibition of autophagy in the heart induces age-related cardiomyopathy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25394488

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/CDD.2014.187

1 reference

Dimensions Publication ID

9 August 2017

1014222300

0 references

Fatcat ID

release_7gzlecjfzbahhbz47u34hjxhne

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7gzlecjfzbahhbz47u34hjxhne

24 November 2022

mapped directly with Wikidata item

PMC publication ID

4423182

1 reference

9 August 2017

1 reference