(Q36979192)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22837537%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22837537%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

0 references

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22837537%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

John P. Morrow

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22837537%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

author name string

Jason C Choi

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22837537%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Wei Wu

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22837537%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Shinichi Iwata

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22837537%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Shunichi Homma

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22837537%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Howard J Worman

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22837537%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

language of work or name

English

0 references

publication date

1 July 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22837537%20AND%20SRC:MED&resulttype=core&format=json

Science Translational Medicine

9 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22837537%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

volume

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22837537%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

issue

144

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22837537%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

page(s)

144ra102

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22837537%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

9 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3700376/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Haploinsufficiency of target of rapamycin attenuates cardiomyopathies in adult zebrafish

29 September 2017

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Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells

29 September 2017

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Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation.

29 September 2017

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Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by mutation in lamin A/C gene

29 September 2017

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29 September 2017

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High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila

29 September 2017

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Functional Coupling between the Extracellular Matrix and Nuclear Lamina by Wnt Signaling in Progeria

29 September 2017

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MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

29 September 2017

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29 September 2017

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Mammalian autophagy: core molecular machinery and signaling regulation

29 September 2017

1 reference

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The nuclear envelope as a signaling node in development and disease.

29 September 2017

1 reference

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A complex interplay between Akt, TSC2 and the two mTOR complexes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700376

Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope

29 September 2017

1 reference

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Inhibition of extracellular signal-regulated kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins.

29 September 2017

1 reference

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Autophagy is an adaptive response in desmin-related cardiomyopathy

29 September 2017

1 reference

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Autophagy in the Pathogenesis of Disease

29 September 2017

1 reference

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FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells

29 September 2017

1 reference

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FoxO3 controls autophagy in skeletal muscle in vivo

29 September 2017

1 reference

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p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

29 September 2017

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The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

29 September 2017

1 reference

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Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy

29 September 2017

1 reference

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

29 September 2017

1 reference

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

29 September 2017

1 reference

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Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.

29 September 2017

1 reference

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

29 September 2017

1 reference

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Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

29 September 2017

1 reference

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Dynamic regulation of MEK/Erks and Akt/GSK-3beta in human end-stage heart failure after left ventricular mechanical support: myocardial mechanotransduction-sensitivity as a possible molecular mechanism

29 September 2017

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Akt regulates growth by directly phosphorylating Tsc2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700376

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

29 September 2017

1 reference

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Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700376

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

29 September 2017

1 reference

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Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart.

29 September 2017

1 reference

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Insulin-like growth factors and their binding proteins: biological actions

29 September 2017

1 reference

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Treatment with selumetinib preserves cardiac function and improves survival in cardiomyopathy caused by mutation in the lamin A/C gene.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700376

Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700376

Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700376

Propranolol prevents enhanced stress signaling in Gs alpha cardiomyopathy: potential mechanism for beta-blockade in heart failure.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700376

Rapamycin attenuates load-induced cardiac hypertrophy in mice

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700376

Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3700376

Differential Activation of Signal Transduction Pathways in Human Hearts With Hypertrophy Versus Advanced Heart Failure

4 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003875

Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003875

Mouse model carrying H222P- Lmna mutation develops muscular dystrophy and dilated cardiomyopathy similar to human striated muscle laminopathies

21 January 2018

1 reference

12 December 2020

Isolation and culture of adult mouse cardiac myocytes

1 reference

12 December 2020

Inhibition of autophagy in the heart induces age-related cardiomyopathy

1 reference

12 December 2020

Rapamycin prevents thyroid hormone-induced cardiac hypertrophy

1 reference

12 December 2020

10.1126/SCITRANSLMED.3003875

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22837537%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22837537%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

PubMed publication ID

22837537

1 reference