(Q34196369)

31 July 2017

title

Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells (English)

1 reference

31 July 2017

1 reference

1 reference

7

Francis S Collins

0 references

author name string

Kan Cao

1

1 reference

31 July 2017

John J Graziotto

2

1 reference

31 July 2017

Cecilia D Blair

3

1 reference

31 July 2017

Joseph R Mazzulli

4

1 reference

31 July 2017

Michael R Erdos

5

1 reference

31 July 2017

Dimitri Krainc

6

1 reference

31 July 2017

language of work or name

English

0 references

publication date

1 June 2011

1 reference

Science Translational Medicine

31 July 2017

published in

1 reference

31 July 2017

volume

3

1 reference

31 July 2017

issue

89

1 reference

31 July 2017

page(s)

89ra58

1 reference

Human laminopathies: nuclei gone genetically awry

31 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

Hutchinson-Gilford progeria syndrome, aging, and the nuclear lamina

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

Phenotype and course of Hutchinson-Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

Extension of chronological life span in yeast by decreased TOR pathway signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

Targeting mammalian target of rapamycin (mTOR) for health and diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

21 January 2018

The two TORCs and Akt.

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

Targeting mTOR with rapamycin: one dose does not fit all

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

TOR signaling in growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

The roles of intracellular protein-degradation pathways in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

The mTOR pathway as a potential target for the development of therapies against neurological disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

Genomic instability in laminopathy-based premature aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

TOR signaling never gets old: aging, longevity and TORC1 activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

Rapamycin alleviates toxicity of different aggregate-prone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

Rapamycin protects against rotenone-induced apoptosis through autophagy induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

A protein conjugation system essential for autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

HIV-1 Vpr induces the K48-linked polyubiquitination and proteasomal degradation of target cellular proteins to activate ATR and promote G2 arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

Ubiquitin-binding domains - from structures to functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

Cardiovascular pathology in Hutchinson-Gilford progeria: correlation with the vascular pathology of aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002346

10.1126/SCITRANSLMED.3002346

21 January 2018

Identifiers

DOI

1 reference

31 July 2017

1 reference