(Q39609180)

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HIV-1 Vpr induces the K48-linked polyubiquitination and proteasomal degradation of target cellular proteins to activate ATR and promote G2 arrest

scientific article published on 20 January 2010

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Europe PubMed Central

PMC publication ID

13 September 2017

HIV-1 Vpr induces the K48-linked polyubiquitination and proteasomal degradation of target cellular proteins to activate ATR and promote G2 arrest (English)

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Europe PubMed Central

PMC publication ID

13 September 2017

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Eric A Cohen

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Europe PubMed Central

PMC publication ID

13 September 2017

author name string

Jean-Philippe Belzile

1

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Europe PubMed Central

PMC publication ID

13 September 2017

Jonathan Richard

2

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Europe PubMed Central

PMC publication ID

13 September 2017

Nicole Rougeau

3

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Europe PubMed Central

PMC publication ID

13 September 2017

Yong Xiao

4

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Europe PubMed Central

PMC publication ID

13 September 2017

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publication date

20 January 2010

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Europe PubMed Central

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13 September 2017

Journal of Virology

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Europe PubMed Central

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13 September 2017

84

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Europe PubMed Central

PMC publication ID

13 September 2017

7

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Europe PubMed Central

PMC publication ID

13 September 2017

3320-3330

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Europe PubMed Central

PMC publication ID

13 September 2017

The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection

1 reference

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Suppression of Tetherin-restricting activity upon human immunodeficiency virus type 1 particle release correlates with localization of Vpu in the trans-Golgi network

1 reference

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Using mass spectrometry to identify ubiquitin and ubiquitin-like protein conjugation sites

1 reference

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Physical and functional interaction between DDB and XPA in nucleotide excision repair

1 reference

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One step at a time: endoplasmic reticulum-associated degradation

1 reference

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PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex

1 reference

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CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation

1 reference

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Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development

1 reference

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HIV-1 accessory proteins--ensuring viral survival in a hostile environment

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Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series

1 reference

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Activation of the cellular DNA damage response in the absence of DNA lesions

1 reference

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Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection

1 reference

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Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction

1 reference

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Polyubiquitin chains: functions, structures, and mechanisms

1 reference

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Evaluation of proteomic strategies for analyzing ubiquitinated proteins

1 reference

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14 September 2017

VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation

1 reference

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Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases

1 reference

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14 September 2017

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

1 reference

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14 September 2017

Requirements for the selective degradation of CD4 receptor molecules by the human immunodeficiency virus type 1 Vpu protein in the endoplasmic reticulum.

1 reference

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14 September 2017

Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation

1 reference

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14 September 2017

Molecular piracy: manipulation of the ubiquitin system by Kaposi's sarcoma-associated herpesvirus

1 reference

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14 September 2017

HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligase

1 reference

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14 September 2017

DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest

1 reference

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14 September 2017

The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor

1 reference

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Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle

1 reference

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DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase

1 reference

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Substrate-mediated regulation of cullin neddylation

1 reference

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HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1

1 reference

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HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase

1 reference

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1 reference

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CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation

1 reference

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Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

1 reference

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Human immunodeficiency virus type 1 Vpr induces DNA replication stress in vitro and in vivo.

1 reference

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A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

1 reference

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DDB1 maintains genome integrity through regulation of Cdt1

1 reference

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1 reference

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1 reference

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Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage

1 reference

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1 reference

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Activation of the ATR pathway by human immunodeficiency virus type 1 Vpr involves its direct binding to chromatin in vivo

1 reference

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Human immunodeficiency virus type 1 Vpr induces the degradation of the UNG and SMUG uracil-DNA glycosylases

1 reference

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UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.

1 reference

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Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

1 reference

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Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation.

1 reference

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Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase

1 reference

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The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

1 reference

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Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein-protein interaction with a novel human cytoplasmic protein VprBP.

1 reference

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Use of a transient assay for studying the genetic determinants of Fv1 restriction

1 reference

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Vpr stimulates viral expression and induces cell killing in human immunodeficiency virus type 1-infected dividing Jurkat T cells

1 reference

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Human immunodeficiency virus type 1 Vpr protein binds to the uracil DNA glycosylase DNA repair enzyme

1 reference

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Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein.

1 reference

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Requirement of the Pr55gag precursor for incorporation of the Vpr product into human immunodeficiency virus type 1 viral particles

1 reference

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The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection.

1 reference

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14 September 2017

The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838092

14 September 2017

Degradation of CFTR by the ubiquitin-proteasome pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838092

14 September 2017

Identification of HIV-1 vpr product and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838092

14 September 2017

HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838092

14 September 2017

SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838092

14 September 2017

Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838092

14 September 2017

Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838092

21 August 2018

Structural determinants for selective recognition of a Lys48-linked polyubiquitin chain by a UBA domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838092

21 August 2018

ATR and GADD45alpha mediate HIV-1 Vpr-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838092

21 August 2018

Identifiers

10.1128/JVI.02590-09

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

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