(Q35581263)

English

Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase

scientific article published on November 1987

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scholarly article

1 reference

Europe PubMed Central

9 August 2017

Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase (English)

1 reference

Europe PubMed Central

9 August 2017

author name string

Hubbard RC

1

1 reference

Europe PubMed Central

9 August 2017

Ogushi F

2

1 reference

Europe PubMed Central

9 August 2017

Fells GA

3

1 reference

Europe PubMed Central

9 August 2017

Cantin AM

4

1 reference

Europe PubMed Central

9 August 2017

Jallat S

5

1 reference

Europe PubMed Central

9 August 2017

Courtney M

6

1 reference

Europe PubMed Central

9 August 2017

Crystal RG

7

1 reference

Europe PubMed Central

9 August 2017

language of work or name

0 references

publication date

1 November 1987

1 reference

Europe PubMed Central

9 August 2017

Journal of Clinical Investigation

1 reference

Europe PubMed Central

9 August 2017

80

1 reference

Europe PubMed Central

9 August 2017

5

1 reference

Europe PubMed Central

9 August 2017

1289-1295

1 reference

Europe PubMed Central

9 August 2017

Structure and variation of human alpha 1-antitrypsin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Kinetics of association of serine proteinases with native and oxidized alpha-1-proteinase inhibitor and alpha-1-antichymotrypsin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Alveolar macrophage replication. One mechanism for the expansion of the mononuclear phagocyte population in the chronically inflamed lung

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Cigarette smoking and lung destruction. Accumulation of neutrophils in the lungs of cigarette smokers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

In vivo significance of kinetic constants of protein proteinase inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Synthesis in yeast of a functional oxidation-resistant mutant of human alpha-antitrypsin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

High-level production of biologically active human alpha 1-antitrypsin in Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Potential mediator of inflammation. Phagocyte-derived oxidants suppress the elastase-inhibitory capacity of alpha 1-proteinase inhibitor in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

The elastase-antielastase hypothesis of the pathogenesis of emphysema

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Human plasma proteinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Antielastases of the human alveolar structures. Implications for the protease-antiprotease theory of emphysema

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Report of Nomenclature Meeting for alpha 1-antitrypsin, INSERM, Rouen/Bois-Guillaume-1978.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Alpha1-antitrypsin and its deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Elastases and emphysema. Current assessment of the protease-antiprotease hypothesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Synthesis in E. coli of alpha 1-antitrypsin variants of therapeutic potential for emphysema and thrombosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Acute effect of smoking on the functional activity of alpha1-protease inhibitor in bronchoalveolar lavage fluid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Secretory products of macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Identification of a second mutation in the protein-coding sequence of the Z type alpha 1-antitrypsin gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

The alveolar macrophage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Alpha-1-antitrypsin content in the serum, alveolar macrophages, and alveolar lavage fluid of smoking and nonsmoking normal subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Small airways in idiopathic pulmonary fibrosis. Comparison of morphologic and physiologic observations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Inflammatory and immune processes in the human lung in health and disease: evaluation by bronchoalveolar lavage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Lung injury induced by leukocytic proteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Origin, Kinetics, and characteristics of pulmonary macrophages in the normal steady state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

alpha1-antitrypsin deficiency (first of two parts).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Cigarette Smoking Induces Functional Antiprotease Deficiency in the Lower Respiratory Tract of Humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

The oxidative inactivation of human alpha-1-proteinase inhibitor. Further evidence for methionine at the reactive center

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Possible mechanisms of emphysema in smokers: cigarette smoke condensate suppresses protease inhibition in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

The effects in vivo and in vitro of oxidative damage to purified alpha1-antitrypsin and to the enzyme-inhibiting activity of plasma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

Possible mechanisms of emphysema in smokers. In vitro suppression of serum elastase-inhibitory capacity by fresh cigarette smoke and its prevention by antioxidants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

12 July 2018

A genetically engineered, mutant human alpha-1-proteinase inhibitor is more resistant than the normal inhibitor to oxidative inactivation by chemicals, enzymes, cells, and cigarette smoke.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=442382

26 September 2018

Altered oxidative metabolic responses in vitro of alveolar macrophages from asymptomatic cigarette smokers

1 reference

https://pubmed.ncbi.nlm.nih.gov/2824559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pathogenesis of emphysema--twenty years of progress

1 reference

https://pubmed.ncbi.nlm.nih.gov/2824559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simple one-step purification of human alpha 1-proteinase inhibitor by immunoadsorbent column chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/2824559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of the elastase inhibitory capacity of alpha 1-antitrypsin by peroxides in cigarette smoke: an analysis of brands and filters

1 reference

https://pubmed.ncbi.nlm.nih.gov/2824559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fate of human neutrophil elastase following receptor-mediated endocytosis by human alveolar macrophages. Implications for connective tissue injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/2824559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional alpha 1-protease inhibitor in the lower respiratory tract of cigarette smokers is not decreased

1 reference

https://pubmed.ncbi.nlm.nih.gov/2824559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The functional activity of alpha 1-proteinase inhibitor in bronchoalveolar lavage fluids from healthy human smokers and non-smokers

1 reference

https://pubmed.ncbi.nlm.nih.gov/2824559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparison of the binding and fate of internalized neutrophil elastase in human monocytes and alveolar macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/2824559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accurate quantification of cells recovered by bronchoalveolar lavage

1 reference

https://pubmed.ncbi.nlm.nih.gov/2824559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A genetically engineered mutant of alpha 1-antitrypsin protects connective tissue from neutrophil damage and may be useful in lung disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/2824559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and properties of recombinant DNA produced variants of human alpha 1-proteinase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/2824559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of recombinant DNA-directed E.coli produced alpha 1-antitrypsin as an anti-neutrophil elastase for potential use as replacement therapy of alpha 1-antitrypsin deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/2824559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution

1 reference

https://pubmed.ncbi.nlm.nih.gov/2824559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute effect of smoking on superoxide production by pulmonary alveolar macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/2824559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathologic changes in the peripheral airways of young cigarette smokers

1 reference

https://pubmed.ncbi.nlm.nih.gov/2824559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI113204

1 reference

Europe PubMed Central

9 August 2017

1 reference

Europe PubMed Central

9 August 2017

1 reference

Europe PubMed Central

9 August 2017

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