(Q35581299)

9 August 2017

title

NOTCH decoys that selectively block DLL/NOTCH or JAG/NOTCH disrupt angiogenesis by unique mechanisms to inhibit tumor growth (English)

1 reference

9 August 2017

Thaned Kangsamaksin

1

1 reference

9 August 2017

Aino Murtomaki

2

1 reference

9 August 2017

Natalie M Kofler

3

1 reference

9 August 2017

Henar Cuervo

4

1 reference

9 August 2017

Reyhaan A Chaudhri

5

1 reference

9 August 2017

Ian W Tattersall

6

1 reference

9 August 2017

Paul E Rosenstiel

7

1 reference

9 August 2017

Carrie J Shawber

8

1 reference

9 August 2017

Jan Kitajewski

9

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9 August 2017

publication date

11 November 2014

1 reference

9 August 2017

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9 August 2017

volume

5

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9 August 2017

issue

2

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9 August 2017

page(s)

182-197

1 reference

Basic and therapeutic aspects of angiogenesis

9 August 2017

cites work

1 reference

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VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.

12 July 2018

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Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression

12 July 2018

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Breast cancer growth and metastasis: interplay between cancer stem cells, embryonic signaling pathways and epithelial-to-mesenchymal transition

12 July 2018

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Gamma-secretase inhibitor treatment promotes VEGF-A-driven blood vessel growth and vascular leakage but disrupts neovascular perfusion

12 July 2018

1 reference

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Notch signalling in solid tumours: a little bit of everything but not all the time

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Notch modulates VEGF action in endothelial cells by inducing Matrix Metalloprotease activity

12 July 2018

1 reference

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Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish.

12 July 2018

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Therapeutic antibody targeting of individual Notch receptors

12 July 2018

1 reference

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DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency

12 July 2018

1 reference

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The canonical Notch signaling pathway: unfolding the activation mechanism

12 July 2018

1 reference

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VEGF and Delta-Notch: interacting signalling pathways in tumour angiogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition

12 July 2018

1 reference

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A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression

12 July 2018

1 reference

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The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Endothelial/pericyte interactions

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Notch3 is required for arterial identity and maturation of vascular smooth muscle cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Calcium depletion dissociates and activates heterodimeric notch receptors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Functional domains of LAG-2, a putative signaling ligand for LIN-12 and GLP-1 receptors in Caenorhabditis elegans

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

A homolog of Drosophila Notch expressed during mammalian development

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

An optimized three-dimensional in vitro model for the analysis of angiogenesis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Structural and functional properties of the human notch-1 ligand binding region.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423829

Chronic DLL4 blockade induces vascular neoplasms

7 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25387766

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/2159-8290.CD-14-0650

1 reference

9 August 2017

1 reference

9 August 2017

1 reference