(Q35587194)

English

A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells

scientific article published on 26 August 2011

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

author name string

Li Lin

1

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Don M Benson

2

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Stephanie DeAngelis

3

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Courtney E Bakan

4

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Pui-Kai Li

5

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Chenglong Li

6

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Jiayuh Lin

7

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

language of work or name

0 references

publication date

26 August 2011

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

International Journal of Cancer

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

130

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

1459-1469

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells

1 reference

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1 reference

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Curcumin in combination with bortezomib synergistically induced apoptosis in human multiple myeloma U266 cells

1 reference

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Beta1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: implications for microenvironment influence on tumor survival and proliferation

1 reference

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12 July 2018

LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model

1 reference

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12 July 2018

Inhibition of the mevalonate pathway potentiates the effects of lenalidomide in myeloma

1 reference

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Cancer statistics, 2008

1 reference

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Design, synthesis, and studies of small molecule STAT3 inhibitors

1 reference

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1 reference

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Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

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Stattic: a small-molecule inhibitor of STAT3 activation and dimerization

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A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo

1 reference

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STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes

1 reference

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12 July 2018

International uniform response criteria for multiple myeloma.

1 reference

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12 July 2018

Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

1 reference

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New and old functions of STAT3: a pivotal target for individualized treatment of cancer

1 reference

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Malignant transformation but not normal cell growth depends on signal transducer and activator of transcription 3.

1 reference

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Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target

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RNA interference in biology and disease

1 reference

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Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice

1 reference

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12 July 2018

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

1 reference

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12 July 2018

Stat3 dimerization regulated by reversible acetylation of a single lysine residue

1 reference

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12 July 2018

Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228889

12 July 2018

Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis.

1 reference

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Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells

1 reference

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Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention

1 reference

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Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells

1 reference

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Multi-functional roles of Stat3 revealed by conditional gene targeting.

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Rac1 mediates STAT3 activation by autocrine IL-6

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STAT proteins: novel molecular targets for cancer drug discovery

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12 December 2020

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10.1002/IJC.26152

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

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