(Q35588397)

9 August 2017

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title

Conformational changes of G protein-coupled receptors during their activation by agonist binding (English)

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G protein-coupled receptor

9 August 2017

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author name string

Caterina Bissantz

series ordinal

1

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9 August 2017

1 January 2003

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Journal of Receptors and Signal Transduction

9 August 2017

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9 August 2017

23

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9 August 2017

123-153

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9 August 2017

2-3

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Modelling G-protein-coupled receptors for drug design

9 August 2017

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Locating ligand-binding sites in 7TM receptors by protein engineering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Rhodopsin mutants that bind but fail to activate transducin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

The amino terminus of the fourth cytoplasmic loop of rhodopsin modulates rhodopsin-transducin interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Mutation of the fourth cytoplasmic loop of rhodopsin affects binding of transducin and peptides derived from the carboxyl-terminal sequences of transducin alpha and gamma subunits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

The many faces of G protein signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Homer: a protein that selectively binds metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

GPCRDB: an information system for G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

G protein-coupled receptors. I. Diversity of receptor-ligand interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Crystal structure of rhodopsin: A G protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs)

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Conformation and orientation of the retinyl chromophore in rhodopsin: a critical evaluation of recent NMR data on the basis of theoretical calculations results in a minimum energy structure consistent with all experimental data

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Two different forms of metarhodopsin II: Schiff base deprotonation precedes proton uptake and signaling state

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Signaling states of rhodopsin. Retinal provides a scaffold for activating proton transfer switches.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Mechanism of rhodopsin activation as examined with ring-constrained retinal analogs and the crystal structure of the ground state protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Biochemical and physiological properties of rhodopsin regenerated with 11-cis-6-ring- and 7-ring-retinals

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Structural features and light-dependent changes in the sequence 59-75 connecting helices I and II in rhodopsin: a site-directed spin-labeling study

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Mapping light-dependent structural changes in the cytoplasmic loop connecting helices C and D in rhodopsin: a site-directed spin labeling study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Structural features and light-dependent changes in the cytoplasmic interhelical E-F loop region of rhodopsin: a site-directed spin-labeling study

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Structure and function in rhodopsin: mapping light-dependent changes in distance between residue 65 in helix TM1 and residues in the sequence 306-319 at the cytoplasmic end of helix TM7 and in helix H8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Structure and function in rhodopsin: mapping light-dependent changes in distance between residue 316 in helix 8 and residues in the sequence 60-75, covering the cytoplasmic end of helices TM1 and TM2 and their connection loop CL1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Light-induced exposure of the cytoplasmic end of transmembrane helix seven in rhodopsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Evidence that helix 8 of rhodopsin acts as a membrane-dependent conformational switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Differential transcriptional activation in vitro by NF-kappa B/Rel proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Conformational changes that occur during M3 muscarinic acetylcholine receptor activation probed by the use of an in situ disulfide cross-linking strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Constitutive activation of opsin: influence of charge at position 134 and size at position 296.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

The activation process of the alpha1B-adrenergic receptor: potential role of protonation and hydrophobicity of a highly conserved aspartate

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Structure and function in rhodopsin: rhodopsin mutants with a neutral amino acid at E134 have a partially activated conformation in the dark state

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

The effect of pH on beta(2) adrenoceptor function. Evidence for protonation-dependent activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Mutagenesis and modelling of the alpha(1b)-adrenergic receptor highlight the role of the helix 3/helix 6 interface in receptor activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Functional role of a conserved motif in TM6 of the rat mu opioid receptor: constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

The local environment at the cytoplasmic end of TM6 of the mu opioid receptor differs from those of rhodopsin and monoamine receptors: introduction of an ionic lock between the cytoplasmic ends of helices 3 and 6 by a L6.30(275)E mutation inactivate

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Constitutively active mutants of rhodopsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Constitutive activation of the delta opioid receptor by mutations in transmembrane domains III and VII.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Activation of the alpha1b-adrenergic receptor is initiated by disruption of an interhelical salt bridge constraint

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Mutation of Asn111 in the third transmembrane domain of the AT1A angiotensin II receptor induces its constitutive activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Constitutive activation of opsin by mutation of methionine 257 on transmembrane helix 6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Highly conserved serine in the third transmembrane helix of the luteinizing hormone/human chorionic gonadotropin receptor regulates receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Molecular basis of partial agonism: orientation of indoleamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Signaling states of rhodopsin. Formation of the storage form, metarhodopsin III, from active metarhodopsin II

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

G protein-coupled receptors. II. Mechanism of agonist activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Single-molecule spectroscopy of the beta(2) adrenergic receptor: observation of conformational substates in a membrane protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

G-protein-coupled receptor dimerization: modulation of receptor function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Dopamine D2 receptor dimers and receptor-blocking peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Dimerization of the delta opioid receptor: implication for a role in receptor internalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Identification and molecular characterization of m3 muscarinic receptor dimers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

A peptide derived from a beta2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Gonadotropin-releasing hormone receptor microaggregation. Rate monitored by fluorescence resonance energy transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Heterodimerization is required for the formation of a functional GABA(B) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

GABA(B)-receptor subtypes assemble into functional heteromeric complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Role of heteromer formation in GABAB receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

G-protein-coupled receptor heterodimerization modulates receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Homo- and heterodimerization of somatostatin receptor subtypes. Inactivation of sst(3) receptor function by heterodimerization with sst(2A).

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Drug design strategies for targeting G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Modeling the 3D structure of GPCRs from sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Prediction of structure and function of G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Modeling of G-protein-coupled receptors: application to dopamine, adrenaline, serotonin, acetylcholine, and mammalian opsin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

The binding site of neuropeptide vasopressin V1a receptor. Evidence for a major localization within transmembrane regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Conserved aromatic residues in the transmembrane region VI of the V1a vasopressin receptor differentiate agonist vs. antagonist ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Crystal structure of rhodopsin: a template for cone visual pigments and other G protein-coupled receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Protein-based virtual screening of chemical databases. II. Are homology models of G-Protein Coupled Receptors suitable targets?

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Protein-based virtual screening of chemical databases. 1. Evaluation of different docking/scoring combinations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Synthesis, biological activity, and molecular modeling of selective 5-HT(2C/2B) receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Binding of Agonist but Not Antagonist Leads to Fluorescence Resonance Energy Transfer between Intrinsically Fluorescent Gonadotropin-Releasing Hormone Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Arrangement of rhodopsin transmembrane α-helices

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Projection structure of rhodopsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Rhodopsin dimers in native disc membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Functional Microdomains in G-protein-coupled Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Movement of retinal along the visual transduction path

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Identification of glutamic acid 113 as the Schiff base proton acceptor in the metarhodopsin II photointermediate of rhodopsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Specific tryptophan UV-absorbance changes are probes of the transition of rhodopsin to its active state

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Conformational changes in rhodopsin. Movement of helix f detected by site-specific chemical labeling and fluorescence spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Structure and function in rhodopsin: effects of disulfide cross-links in the cytoplasmic face of rhodopsin on transducin activation and phosphorylation by rhodopsin kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-specific conformational changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Tertiary interactions between the fifth and sixth transmembrane segments of rhodopsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

G protein-coupled receptor activation: analysis of a highly constrained, "straitjacketed" rhodopsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Interactions between conserved residues in transmembrane helices 1, 2, and 7 of the thyrotropin-releasing hormone receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Photoactivated conformational changes in rhodopsin: a time-resolved spin label study

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Metabotropic glutamate receptor 5 is a disulfide-linked dimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Three-dimensional representations of G protein-coupled receptor structures and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

Modelling of the binding site of the human m1 muscarinic receptor: experimental validation and refinement

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FRRS-120025192

21 January 2018

Identifiers

DOI

10.1081/RRS-120025192

1 reference

9 August 2017

1 reference

PubMed ID

14626443