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The human sirtuin family: evolutionary divergences and functions.
scientific article published on July 2011
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Europe PubMed Central
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3230576
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21807603%20AND%20SRC:MED&resulttype=core&format=json
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9 February 2020
title
The human sirtuin family: evolutionary divergences and functions
(English)
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Europe PubMed Central
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3230576
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21807603%20AND%20SRC:MED&resulttype=core&format=json
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9 February 2020
author
Kristofer S Fritz
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2
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Europe PubMed Central
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3230576
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9 February 2020
author name string
Athanassios Vassilopoulos
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1
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Europe PubMed Central
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3230576
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9 February 2020
Dennis R Petersen
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3
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9 February 2020
David Gius
series ordinal
4
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9 February 2020
publication date
1 July 2011
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9 February 2020
published in
Human genomics
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Europe PubMed Central
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3230576
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21807603%20AND%20SRC:MED&resulttype=core&format=json
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9 February 2020
volume
5
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Europe PubMed Central
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9 February 2020
issue
5
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9 February 2020
page(s)
485-496
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Europe PubMed Central
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3230576
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9 February 2020
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Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes
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Human SIRT6 promotes DNA end resection through CtIP deacetylation
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SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
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Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis
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SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span
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SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention--the TULIP Study
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Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
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A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
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SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression
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Lysine acetylation: codified crosstalk with other posttranslational modifications
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Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5
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SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization
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Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice
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Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5
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Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
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12 July 2018
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival
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12 July 2018
Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis
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12 July 2018
Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase
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12 July 2018
Histone deacetylases and cancer
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12 July 2018
SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation
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12 July 2018
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease
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12 July 2018
Sirtuins in mammals: insights into their biological function
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12 July 2018
SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress
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12 July 2018
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin
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12 July 2018
MAR1-a Regulator of the HMa and HMalpha Loci in SACCHAROMYCES CEREVISIAE
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Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
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12 July 2018
Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13.
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12 July 2018
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells
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SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress
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12 July 2018
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2
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12 July 2018
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12 July 2018
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription
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Fluorescence in situ hybridization and chromosomal organization of the human Sirtuin 7 gene.
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12 July 2018
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
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12 July 2018
Chromosomal organization and fluorescence in situ hybridization of the human Sirtuin 6 gene.
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12 July 2018
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase
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12 July 2018
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
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12 July 2018
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
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12 July 2018
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
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12 July 2018
Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene
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12 July 2018
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
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12 July 2018
Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
12 July 2018
Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
12 July 2018
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
12 July 2018
Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
12 July 2018
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
12 July 2018
SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
12 July 2018
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
12 July 2018
PPAR(gamma) and glucose homeostasis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
12 July 2018
The interaction of Alba, a conserved archaeal chromatin protein, with Sir2 and its regulation by acetylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
12 July 2018
Histone deacetylases and cancer: causes and therapies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
12 July 2018
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
12 July 2018
Negative control of p53 by Sir2alpha promotes cell survival under stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
12 July 2018
Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
12 July 2018
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
12 July 2018
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
12 July 2018
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
12 July 2018
Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
12 July 2018
Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
12 July 2018
Sirtuin 1 gene polymorphisms are associated with body fat and blood pressure in Japanese.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
26 September 2018
Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
26 September 2018
Urea cycle regulation by mitochondrial sirtuin, SIRT5.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
26 September 2018
The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
26 September 2018
SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
26 September 2018
Association of SIRT1 gene variation with visceral obesity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
26 September 2018
SIRT1 gene, age-related diseases, and mortality: the Leiden 85-plus study.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
26 September 2018
Sirt1 regulates aging and resistance to oxidative stress in the heart
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
26 September 2018
Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
26 September 2018
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
26 September 2018
Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3230576
retrieved
26 September 2018
Distinct regulation of mitochondrial localization and stability of two human Sirt5 isoforms
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21807603
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1186/1479-7364-5-5-485
1 reference
stated in
Europe PubMed Central
PMC publication ID
3230576
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21807603%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
PMC publication ID
3230576
1 reference
stated in
Europe PubMed Central
PMC publication ID
3230576
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21807603%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
PubMed publication ID
21807603
1 reference
stated in
Europe PubMed Central
PMC publication ID
3230576
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21807603%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
ResearchGate publication ID
51538815
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