(Q35595389)

9 August 2017

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title

Pharmacokinetic and pharmacodynamic considerations in gene therapy (English)

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9 August 2017

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Hiroyuki Kamiya

1

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9 August 2017

Hidetaka Akita

series ordinal

2

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9 August 2017

Hideyoshi Harashima

series ordinal

3

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9 August 2017

publication date

1 November 2003

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9 August 2017

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9 August 2017

volume

8

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9 August 2017

issue

21

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9 August 2017

page(s)

990-996

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Pharmacokinetics of targeting with liposomes

9 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Intracellular control of gene trafficking using liposomes as drug carriers

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Intracellular trafficking and transgene expression of viral and non-viral gene vectors

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Potentiation of cationic liposome-mediated gene delivery by polycations

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Identification of proteins mediating clearance of liposomes using a liver perfusion system

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Stabilized plasmid-lipid particles: construction and characterization

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Stabilized plasmid-lipid particles for systemic gene therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Stabilized plasmid-lipid particles: pharmacokinetics and plasmid delivery to distal tumors following intravenous injection

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Strength of conjugate binding to plasmid DNA affects degradation rate and expression level in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Noninvasive gene targeting to the brain

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Brain-specific expression of an exogenous gene after i.v. administration

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Adenovirus enhancement of transferrin-polylysine-mediated gene delivery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Application of membrane-active peptides for nonviral gene delivery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Endocytosis and intracellular processing accompanying transfection mediated by cationic liposomes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

DNA transfection mediated by cationic liposomes containing lipopolylysine: characterization and mechanism of action

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Polyethylenimine-mediated gene delivery: a mechanistic study

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Effects of polyethyleneimine on endocytosis and lysosome stability

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Transfection of human macrophages by lipoplexes via the combined use of transferrin and pH-sensitive peptides

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Intracellular barriers to non-viral gene transfer.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Mitosis enhances transgene expression of plasmid delivered by cationic liposomes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

DNA vector chemistry: the covalent attachment of signal peptides to plasmid DNA

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Nuclear targeting peptide scaffolds for lipofection of nondividing mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Using nuclear targeting signals to enhance non-viral gene transfer

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Can nuclear localization signals enhance nuclear localization of plasmid DNA?

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Quantitative analysis of synthetic gene delivery vector design properties

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Visualization of intracellular trafficking of exogenous DNA delivered by cationic liposomes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Quantitative studies on the nuclear transport of plasmid DNA and gene expression employing nonviral vectors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Quantitative analysis of correlation between number of nuclear plasmids and gene expression activity after transfection with cationic liposomes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Polyethylenimine-mediated cellular uptake, nucleus trafficking and expression of cytokine plasmid DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Fiber swap between adenovirus subgroups B and C alters intracellular trafficking of adenovirus gene transfer vectors.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Cell delivery, intracellular trafficking and expression of an integrin-mediated gene transfer vector in tracheal epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Size and topology of exogenous DNA as determinant factors of transgene transcription in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Molecular mechanisms of gene silencing mediated by DNA methylation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

DNA methylation has a local effect on transcription and histone acetylation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

The effect of cell division on the cellular dynamics of microinjected DNA and dextran

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

The HIV-1 gp41 N-terminal heptad repeat plays an essential role in membrane fusion

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Fusogenic activity of SIV (simian immunodeficiency virus) peptides located in the GP32 NH2 terminal domain

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Sendai virus N-terminal fusion peptide consists of two similar repeats, both of which contribute to membrane fusion

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

pH-induced alterations in the fusogenic spike protein of Semliki Forest virus

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Low pH-dependent Sindbis virus-induced fusion of BHK cells: differences between strains correlate with amino acid changes in the E1 glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Mechanisms of gene transfer mediated by lipoplexes associated with targeting ligands or pH-sensitive peptides

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

New basic membrane-destabilizing peptides for plasmid-based gene delivery in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Transfection using synthetic peptides: comparison of three DNA-compacting peptides and effect of centrifugation.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Protein transduction technology

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Stearylated arginine-rich peptides: a new class of transfection systems

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Structural variety of arginine-rich RNA-binding peptides

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Characterization of cardiac muscle factor 1 sequence motifs: retinoblastoma protein binding and nuclear localization.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Differential expression and sequence-specific interaction of karyopherin alpha with nuclear localization sequences

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

Differential modes of nuclear localization signal (NLS) recognition by three distinct classes of NLS receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

A nuclear localization domain in the hnRNP A1 protein

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902889-7

7 January 2021

10.1016/S1359-6446(03)02889-7

Identifiers

DOI

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9 August 2017

1 reference