(Q35596317)

English

An interleukin 12 p40-IgG2b fusion protein abrogates T cell mediated inflammation: anti-inflammatory activity in Crohn's disease and experimental colitis in vivo

scientific article published on March 2004

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

An interleukin 12 p40-IgG2b fusion protein abrogates T cell mediated inflammation: anti-inflammatory activity in Crohn's disease and experimental colitis in vivo (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Crohn's disease

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1 reference

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author name string

A Stallmach

1

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

T Marth

2

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

B Weiss

3

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

B M Wittig

4

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

A Hombach

5

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

C Schmidt

6

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

M Neurath

7

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

M Zeitz

8

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

S Zeuzem

9

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

H Abken

10

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

language of work or name

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publication date

1 March 2004

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Europe PubMed Central

PubMed publication ID

9 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

53

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

339-345

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Regulation of experimental mucosal inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Decreased Bax expression by mucosal T cells favours resistance to apoptosis in Crohn's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Up-regulation of the IL-12 receptor beta 2 chain in Crohn's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The Interleukin 10 Inflammatory Bowel Disease Cooperative Study Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Safety and efficacy of recombinant human interleukin 10 in chronic active Crohn's disease. Crohn's Disease IL-10 Cooperative Study Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Resistance of Crohn's disease T cells to multiple apoptotic signals is associated with a Bcl-2/Bax mucosal imbalance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Inflammatory bowel disease: etiology and pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-gamma promoter in primary CD4+ T lymphocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Interleukin-12 expression is focally enhanced in the gastric mucosa of pediatric patients with Crohn's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn's disease. Crohn's Disease Study Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Pathogenesis of inflammatory bowel disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

IL-12-deficient mice are defective but not devoid of type 1 cytokine responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Interleukin-10-deficient mice develop chronic enterocolitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Antibodies to interleukin 12 abrogate established experimental colitis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

12 July 2018

Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

26 September 2018

Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-induced colitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

26 September 2018

A protective and agonistic function of IL-12p40 in mycobacterial infection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

26 September 2018

Activation of beta(1) integrins mediates proliferation and inhibits apoptosis of intestinal CD4-positive lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

26 September 2018

Curative treatment of an experimentally induced colitis by a CD44 variant V7-specific antibody.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

26 September 2018

A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773960

26 September 2018

Anti-IL12 imposes the death sentence on Th1 cells in TNBS colitis--is there a light at the end of the tunnel for Crohn's disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/14960512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An engineered human antibody to TNF (CDP571) for active Crohn's disease: a randomized double-blind placebo-controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/14960512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/14960512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/14960512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-12 antagonist activity of mouse interleukin-12 p40 homodimer in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/14960512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction and prevention of colonic inflammation in IL-2-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/14960512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4+ and CD8+ IFN-gamma-producing cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14960512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bioactive murine and human interleukin-12 fusion proteins which retain antitumor activity in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/14960512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14960512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lamina propria T cells in Crohn's disease and other gastrointestinal inflammation show defective CD2 pathway-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14960512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel function of IL-12p40 as a chemotactic molecule for macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/14960512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection of trinitrobenzene sulfonic acid-induced colitis by an interleukin 2-IgG2b fusion protein in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/14960512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of interleukin-12 receptor beta(2) on lamina propria mononuclear cells of patients with active Crohn's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/14960512

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1136/GUT.2003.020107

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

ResearchGate publication ID

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