(Q39654574)

English

In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70.

scientific article published on April 2002

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70. (English)

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

0 references

Francisella tularensis

object named as

Francisella tularensis

1 reference

based on heuristic

inferred from title

author name string

Karen L Elkins

1

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Allison Cooper

2

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Susan M Colombini

3

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Siobhán C Cowley

4

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Tara L Kieffer

5

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

language of work or name

0 references

publication date

1 April 2002

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Infection and Immunity

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

70

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

4

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

1936-1948

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Susceptibility to secondary Francisella tularensis live vaccine strain infection in B-cell-deficient mice is associated with neutrophilia but not with defects in specific T-cell-mediated immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

Interferon-gamma and interleukin-12 pathway defects and human disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

Depletion of CD4(+) T cells causes reactivation of murine persistent tuberculosis despite continued expression of interferon gamma and nitric oxide synthase 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

Roles of interleukin-12 and gamma interferon in murine Chlamydia pneumoniae infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

Regulation of the IL-12/IL-12R axis: a critical step in T-helper cell differentiation and effector function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

Importance of B cells, but not specific antibodies, in primary and secondary protective immunity to the intracellular bacterium Francisella tularensis live vaccine strain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

Interleukin 12-dependent interferon gamma production by CD8alpha+ lymphoid dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

Rapid local expression of interleukin-12, tumor necrosis factor alpha, and gamma interferon after cutaneous Francisella tularensis infection in tularemia-immune mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

Interleukin-12 is indispensable for protective immunity against Leishmania major

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-gamma-dependent and -independent pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

Minimal requirements for murine resistance to infection with Francisella tularensis LVS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

T-cell-independent resistance to infection and generation of immunity to Francisella tularensis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

Transfer of immunity against lethal murine Francisella infection by specific antibody depends on host gamma interferon and T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

Antimicrobial susceptibility testing of Francisella tularensis with a modified Mueller-Hinton broth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

Nature of protective immunity to Francisella tularensis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

Live vaccine strain of Francisella tularensis: infection and immunity in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

In vivo modulation of the murine immune response to Francisella tularensis LVS by administration of anticytokine antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

Activation of macrophages for destruction of Francisella tularensis: identification of cytokines, effector cells, and effector molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

14 September 2017

Adaptive immunity and enhanced CD8+ T cell response to Listeria monocytogenes in the absence of perforin and IFN-gamma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

25 September 2017

Novel human immunodeficiencies reveal the essential role of type-I cytokines in immunity to intracellular bacteria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

15 June 2018

Loss of either CD4+ or CD8+ T cells does not affect the magnitude of protective immunity to an intracellular pathogen, Francisella tularensis strain LVS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

15 June 2018

The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

15 June 2018

Secondary response to Listeria infection requires IFN-gamma but is partially independent of IL-12.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

15 June 2018

The requirement for gamma interferon in resistance of mice to experimental tularemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

15 June 2018

Introduction of Francisella tularensis at skin sites induces resistance to infection and generation of protective immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

15 June 2018

A protective and agonistic function of IL-12p40 in mycobacterial infection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

21 August 2018

Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

21 August 2018

Confrontation between intracellular bacteria and the immune system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

21 August 2018

Lack of both types 1 and 2 cytokines, tissue inflammatory responses, and immune protection during pulmonary infection by Mycobacterium bovis bacille Calmette-Guérin in IL-12-deficient mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

21 August 2018

Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

21 August 2018

The requirement of tumour necrosis factor-alpha and interferon-gamma for the expression of protective immunity to secondary murine tularaemia depends on the size of the challenge inoculum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

21 August 2018

Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

21 August 2018

Interleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

21 August 2018

IFN-gamma-independent IgG2a production in mice infected with viruses and parasites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=127864

2 December 2018

IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11895957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific immunity to Listeria monocytogenes in the absence of IFN gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11895957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The IL-12 p40 homodimer as a specific antagonist of the IL-12 heterodimer

1 reference

https://pubmed.ncbi.nlm.nih.gov/11895957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/11895957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-12 is not required for induction of type 1 cytokine responses in viral infections

1 reference

https://pubmed.ncbi.nlm.nih.gov/11895957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytogenes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11895957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11895957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii

1 reference

https://pubmed.ncbi.nlm.nih.gov/11895957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11895957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide-independent killing of Francisella tularensis by IFN-gamma-stimulated murine alveolar macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/11895957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/IAI.70.4.1936-1948.2002

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

release_6wbqcgyfkreupcapitycj6bbtq

1 reference

https://api.fatcat.wiki/v0/release/6wbqcgyfkreupcapitycj6bbtq

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

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