(Q35597121)

9 August 2017

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title

Taking our breath away: dendritic cells in the pathogenesis of asthma (English)

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9 August 2017

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1

Bart N Lambrecht

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9 August 2017

Hamida Hammad

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9 August 2017

1 December 2003

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Nature Reviews Immunology

9 August 2017

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9 August 2017

3

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9 August 2017

994-1003

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9 August 2017

12

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https://scigraph.springernature.com/pub.10.1038/nri1249

9 August 2017

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Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes

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Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity

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T cell fitness determined by signal strength

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Mucosal CD8alpha+ DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory properties

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Accelerated migration of respiratory dendritic cells to the regional lymph nodes is limited to the early phase of pulmonary infection

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Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation

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GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice

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Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ

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IL-6 Production by Pulmonary Dendritic Cells Impedes Th1 Immune Responses

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Lipopolysaccharide-induced suppression of airway Th2 responses does not require IL-12 production by dendritic cells.

31 March 2020

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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

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Differential T cell function and fate in lymph node and nonlymphoid tissues

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Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma

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Preferential accumulation of antigen-specific effector CD4 T cells at an antigen injection site involves CD62E-dependent migration but not local proliferation

31 March 2020

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A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure

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OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation

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Th type 1-stimulating activity of lung macrophages inhibits Th2-mediated allergic airway inflammation by an IFN-gamma-dependent mechanism

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Distribution and immunophenotype of mononuclear phagocytes and dendritic cells in the human lung

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Allergic eosinophil-rich inflammation develops in lungs and airways of B cell-deficient mice

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Lymph node trafficking and antigen presentation by endobronchial eosinophils

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A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the mouse

31 March 2020

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Anti-interleukin 5 but not anti-IgE prevents airway inflammation and airway hyperresponsiveness

31 March 2020

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Airway eosinophils accumulate in the mediastinal lymph nodes but lack antigen-presenting potential for naive T cells

31 March 2020

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Th2 polarization by Der p 1--pulsed monocyte-derived dendritic cells is due to the allergic status of the donors

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Extensive eosinophil degranulation and peroxidase-mediated oxidation of airway proteins do not occur in a mouse ovalbumin-challenge model of pulmonary inflammation.

31 March 2020

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Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model

31 March 2020

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Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma

31 March 2020

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Meeting Koch's postulates for calcium signaling in cardiac hypertrophy

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31 March 2020

Identifiers

DOI

10.1038/NRI1249

1 reference

PubMed ID

14647481

Dimensions Publication ID

9 August 2017

0 references

1 reference

PubMed ID

14647481