(Q35600324)

9 August 2017

title

Lentiviral vector-based insertional mutagenesis identifies genes involved in the resistance to targeted anticancer therapies (English)

1 reference

9 August 2017

7

Luigi Naldini

0 references

Andrea Calabria

object named as

Andrea Calabria

3

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Eugenio Montini

object named as

Eugenio Montini

8

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author name string

Marco Ranzani

1

1 reference

9 August 2017

Stefano Annunziato

2

1 reference

9 August 2017

Stefano Brasca

4

1 reference

9 August 2017

Fabrizio Benedicenti

5

1 reference

9 August 2017

Pierangela Gallina

6

1 reference

9 August 2017

publication date

8 September 2014

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9 August 2017

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9 August 2017

volume

22

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9 August 2017

issue

12

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9 August 2017

page(s)

2056-2068

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Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo

9 August 2017

cites work

1 reference

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12 July 2018

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Cancer drug resistance: an evolving paradigm

12 July 2018

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From bench to bedside: lessons learned in translating preclinical studies in cancer drug development

12 July 2018

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Effect of IRS4 levels on PI 3-kinase signalling

12 July 2018

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Effective response of doxorubicin-sensitive and -resistant breast cancer cells to combinational siRNA therapy

12 July 2018

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Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies

12 July 2018

1 reference

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Cancer gene discovery: exploiting insertional mutagenesis

12 July 2018

1 reference

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Outcome impact of PIK3CA mutations in HER2-positive breast cancer patients treated with trastuzumab

12 July 2018

1 reference

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Cullin1 is a novel marker of poor prognosis and a potential therapeutic target in human breast cancer

12 July 2018

1 reference

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Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

12 July 2018

1 reference

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Transposon activation mutagenesis as a screening tool for identifying resistance to cancer therapeutics

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer

12 July 2018

1 reference

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The landscape of cancer genes and mutational processes in breast cancer

12 July 2018

1 reference

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Cancer treatment and survivorship statistics, 2012

12 July 2018

1 reference

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Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent

12 July 2018

1 reference

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Circumventing cancer drug resistance in the era of personalized medicine

12 July 2018

1 reference

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Systematic identification of genomic markers of drug sensitivity in cancer cells

12 July 2018

1 reference

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Jetset: selecting the optimal microarray probe set to represent a gene

12 July 2018

1 reference

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Treatment of HER2-positive breast cancer: current status and future perspectives.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

Exploring the genomes of cancer cells: progress and promise

12 July 2018

1 reference

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A beta version of life: p110β takes center stage

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

Molecular therapy of breast cancer: progress and future directions

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

Activated phosphoinositide 3-kinase/AKT signaling confers resistance to trastuzumab but not lapatinib

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

PIKing the right isoform: the emergent role of the p110beta subunit in breast cancer.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

Pancreatic cancer: molecular pathogenesis and new therapeutic targets

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

High-throughput insertional mutagenesis screens in mice to identify oncogenic networks

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

12 July 2018

1 reference

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Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

PTEN-deficient cancers depend on PIK3CB.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

Functional identification of genes causing estrogen independence of human breast cancer cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

Comprehensive analysis of oncogenic effects of PIK3CA mutations in human mammary epithelial cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

Real-time definition of non-randomness in the distribution of genomic events

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

Delineation of molecular mechanisms of sensitivity to lapatinib in breast cancer cell lines using global gene expression profiles

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

High-resolution genomic profiles of breast cancer cell lines assessed by tiling BAC array comparative genomic hybridization

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

Lapatinib plus capecitabine for HER2-positive advanced breast cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

Relevance of breast cancer cell lines as models for breast tumours: an update

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1)

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

HIV-1 integration in the human genome favors active genes and local hotspots

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of bcar-1, a common integration site

12 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

12 July 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

High-resolution insertion-site analysis by linear amplification-mediated PCR (LAM-PCR).

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429698

The pea3 subfamily ets genes are required for HER2/Neu-mediated mammary oncogenesis

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FMT.2014.174

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/MT.2014.174

1 reference

9 August 2017

1 reference

9 August 2017

1 reference