(Q35604967)

English

Carbohydrate metabolism is perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) suppression

scientific article published on 14 October 2011

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scholarly article

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Europe PubMed Central

PubMed publication ID

9 August 2017

Carbohydrate metabolism is perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) suppression (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Sjoerd van den Berg

object named as

Sjoerd van den Berg

3

0 references

Ko Willems van Dijk

object named as

Ko Willems van Dijk

8

0 references

Peter Carmeliet

10

object named as

Peter Carmeliet

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Paul P Van Veldhoven

9

object named as

Paul P Van Veldhoven

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

author name string

Annelies Peeters

1

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Peter Fraisl

2

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Emiel Ver Loren van Themaat

4

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Antoine Van Kampen

5

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Mark H Rider

6

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Hiroshi Takemori

7

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Myriam Baes

11

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

language of work or name

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publication date

14 October 2011

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

9 August 2017

286

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

49

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

42162-42179

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Sensing of energy and nutrients by AMP-activated protein kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Role of PPAR in Hepatic Carbohydrate Metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

AMP-activated protein kinase and its downstream transcriptional pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Phosphorylation of the CREB-specific coactivator TORC2 at Ser(307) regulates its intracellular localization in COS-7 cells and in the mouse liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Signal transduction mechanism of TRB3 in rats with non-alcoholic fatty liver disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Coordinate induction of PPAR alpha and SREBP2 in multifunctional protein 2 deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Mitochondrial hepatopathies: advances in genetics and pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Peroxisome biogenesis disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Peroxisomes and oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Biochemistry of mammalian peroxisomes revisited

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

AMP-activated protein kinase--development of the energy sensor concept.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Absence of peroxisomes in mouse hepatocytes causes mitochondrial and ER abnormalities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Lack of evidence for a role of TRB3/NIPK as an inhibitor of PKB-mediated insulin signalling in primary hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Histopathologic approach to metabolic liver disease: Part 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Biochemical studies in the liver and muscle of patients with Zellweger syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Ultrastructure of the Liver in the Cerebrohepatorenal Syndrome of Zellweger

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Peroxisomal and mitochondrial defects in the cerebro-hepato-renal syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Table of nonprotein respiratory quotient: an update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Kinetic mechanism of phosphoenolpyruvate carboxykinase (GTP) from rat liver cytosol. Product inhibition, isotope exchange at equilibrium, and partial reactions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Light and electron microscopic liver changes in the cerebro-hepato-renal syndrome of Zellweger (Peroxisome deficiency) (author's transl)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234943

27 July 2018

Generation of Pex5-loxP mice allowing the conditional elimination of peroxisomes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.299727

21 January 2018

High levels of whole-body energy expenditure are associated with a lower coupling of skeletal muscle mitochondria in C57Bl/6 mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.299727

21 January 2018

Induction of PEPCK gene expression in insulinopenia in rat small intestine.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.299727

21 January 2018

Measurements of ATP in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.299727

21 January 2018

Beta-oxidation in hepatocyte cultures from mice with peroxisomal gene knockouts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.299727

21 January 2018

Hepatosteatosis in peroxisome deficient liver despite increased β-oxidation capacity and impaired lipogenesis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.299727

21 January 2018

PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.299727

21 January 2018

Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.299727

21 January 2018

AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.299727

21 January 2018

AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.299727

21 January 2018

Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.299727

21 January 2018

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.299727

21 January 2018

Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.299727

21 January 2018

Pathology of hepatic peroxisomes and mitochondria in patients with peroxisomal disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/22002056

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iodixanol (Optiprep), an improved density gradient medium for the iso-osmotic isolation of rat liver peroxisomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22002056

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of the peroxisomal multifunctional protein-2 in mice impedes the degradation of not only 2-methyl-branched fatty acids and bile acid intermediates but also of very long chain fatty acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/22002056

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver in the cerebro-hepato-renal syndrome: defective bile acid synthesis and abnormal mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/22002056

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22002056

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22002056

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22002056

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/22002056

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of benfluorex and fenofibrate treatment on mitochondrial and peroxisomal marker enzymes in rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/22002056

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A kinetic study of pyrophosphate: fructose-6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose 2,6-bisphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/22002056

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.299727

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

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