(Q35607710)

9 August 2017

title

A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activity (English)

1 reference

9 August 2017

Erick T Tjhin

2

0 references

Lizbé Koekemoer

Lizbé Koekemoer

5

0 references

Marianne de Villiers

Marianne de Villiers

6

0 references

Erick Strauss

Erick Strauss

8

0 references

Kevin J. Saliba

Kevin J Saliba

7

0 references

author name string

Cristiano J Macuamule

1

1 reference

9 August 2017

Collins E Jana

3

1 reference

9 August 2017

Leanne Barnard

4

1 reference

9 August 2017

language of work or name

English

0 references

publication date

6 April 2015

1 reference

Antimicrobial Agents and Chemotherapy

9 August 2017

published in

1 reference

9 August 2017

volume

59

1 reference

9 August 2017

issue

6

1 reference

9 August 2017

page(s)

3666-3668

1 reference

Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activity

9 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432145

Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432145

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432145

Four-year efficacy of RTS,S/AS01E and its interaction with malaria exposure

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432145

Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432145

Antimalarial activity of the anticancer histone deacetylase inhibitor SB939.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432145

Pantothenate utilization by Plasmodium as a target for antimalarial chemotherapy

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432145

Inhibition of Plasmodium falciparum pH regulation by small molecule indole derivatives results in rapid parasite death

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432145

Coenzyme A biosynthesis: an antimicrobial drug target

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432145

A class of pantothenic acid analogs inhibits Plasmodium falciparum pantothenate kinase and represses the proliferation of malaria parasites

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432145

Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432145

The nitrilase superfamily: classification, structure and function

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432145

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432145

Nutritional requirements of Plasmodium falciparum in culture. I. Exogenously supplied dialyzable components necessary for continuous growth

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432145

A novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432145

From crystal to compound: structure-based antimalarial drug discovery

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432145

Diverse biological activities of the vascular non-inflammatory molecules - the Vanin pantetheinases

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432145

CJ-15,801, a fungal natural product, inhibits the intraerythrocytic stage of Plasmodium falciparum in vitro via an effect on pantothenic acid utilisation

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4432145

Assay of the enzymatic hydrolysis of pantetheine

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25845876

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Purification and properties of a pantetheine-hydrolyzing enzyme from pig kidney

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25845876

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/AAC.04970-14

1 reference

9 August 2017

1 reference

9 August 2017

1 reference