(Q35612218)

English

Oncogenic HRAS Activates Epithelial-to-Mesenchymal Transition and Confers Stemness to p53-Deficient Urothelial Cells to Drive Muscle Invasion of Basal Subtype Carcinomas

scientific article published on 20 March 2015

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scholarly article

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3 March 2020

Oncogenic HRAS Activates Epithelial-to-Mesenchymal Transition and Confers Stemness to p53-Deficient Urothelial Cells to Drive Muscle Invasion of Basal Subtype Carcinomas (English)

1 reference

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3 March 2020

Jonathan Melamed

2

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3 March 2020

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3 March 2020

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3 March 2020

author name string

Feng He

1

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3 March 2020

Moon-Shong Tang

3

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20 March 2015

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3 March 2020

Cancer Research

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3 March 2020

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3 March 2020

10

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3 March 2020

2017-2028

1 reference

Europe PubMed Central

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3 March 2020

Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancers

1 reference

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Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin

1 reference

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Cellular origin of bladder neoplasia and tissue dynamics of its progression to invasive carcinoma

1 reference

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27 July 2018

Dragging ras back in the ring

1 reference

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27 July 2018

Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy

1 reference

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27 July 2018

Molecular subtyping of invasive bladder cancer: time to divide and rule?

1 reference

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27 July 2018

Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology

1 reference

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27 July 2018

Comprehensive molecular characterization of urothelial bladder carcinoma

1 reference

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27 July 2018

Pharmacogenomics in bladder cancer

1 reference

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27 July 2018

Blood- and tissue-based biomarkers for prediction of outcomes in urothelial carcinoma of the bladder

1 reference

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Accelerating cancer modeling with RNAi and nongermline genetically engineered mouse models

1 reference

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27 July 2018

Mutational landscape and significance across 12 major cancer types

1 reference

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27 July 2018

Retinoid signaling in progenitors controls specification and regeneration of the urothelium

1 reference

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27 July 2018

The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis

1 reference

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27 July 2018

Toward a molecular pathologic classification of urothelial carcinoma.

1 reference

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27 July 2018

Current preclinical models for the advancement of translational bladder cancer research

1 reference

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27 July 2018

A systematic review of neoadjuvant and adjuvant chemotherapy for muscle-invasive bladder cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433590

27 July 2018

Three differentiation states risk-stratify bladder cancer into distinct subtypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433590

27 July 2018

Urothelial tumor initiation requires deregulation of multiple signaling pathways: implications in target-based therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433590

27 July 2018

Combination of a novel gene expression signature with a clinical nomogram improves the prediction of survival in high-risk bladder cancer.

1 reference

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27 July 2018

Failsafe program escape and EMT: a deleterious partnership.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433590

27 July 2018

Phase III study of molecularly targeted adjuvant therapy in locally advanced urothelial cancer of the bladder based on p53 status

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433590

27 July 2018

K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433590

27 July 2018

p53 and its mutants in tumor cell migration and invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433590

27 July 2018

Molecular pathways of urothelial development and bladder tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433590

27 July 2018

Deficiency of pRb family proteins and p53 in invasive urothelial tumorigenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433590

27 July 2018

Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433590

27 July 2018

Potential new urinary markers in the early detection of bladder cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433590

27 July 2018

Uroplakins in urothelial biology, function, and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433590

27 July 2018

Inactivation of p53 and Pten promotes invasive bladder cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433590

27 July 2018

Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433590

27 July 2018

Persistent uroplakin expression in advanced urothelial carcinomas: implications in urothelial tumor progression and clinical outcome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433590

27 July 2018

Vimentin and epithelial-mesenchymal transition in human breast cancer--observations in vitro and in vivo.

1 reference

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27 July 2018

Investigations of rodent urinary bladder carcinogens: collection, processing, and evaluation of urine and bladders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433590

27 July 2018

Hyperactivation of Ha-ras oncogene, but not Ink4a/Arf deficiency, triggers bladder tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433590

27 July 2018

Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433590

27 July 2018

Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433590

27 July 2018

Urothelial tumorigenesis: a tale of divergent pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433590

27 July 2018

Focus on bladder cancer

1 reference

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27 July 2018

p53 deficiency provokes urothelial proliferation and synergizes with activated Ha-ras in promoting urothelial tumorigenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433590

27 July 2018

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

1 reference

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27 July 2018

Superficial bladder cancer: decreasing the risk of recurrence

1 reference

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27 July 2018

A Human Tissue Culture Cell Line from a Transitional Cell Tumour of the Urinary Bladder: Growth, Chromosome Pattern and Ultrastructure

1 reference

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27 July 2018

Bladder cancers arise from distinct urothelial sub-populations.

1 reference

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25 September 2018

Novel markers of squamous differentiation in the urinary bladder.

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25 September 2018

Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer

1 reference

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25 September 2018

Key concerns about the current state of bladder cancer: a position paper from the Bladder Cancer Think Tank, the Bladder Cancer Advocacy Network, and the Society of Urologic Oncology.

1 reference

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25 September 2018

Tumor suppressor genes of bladder cancer and potential for gene therapy.

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25 September 2018

FGFR3 and P53 characterize alternative genetic pathways in the pathogenesis of urothelial cell carcinoma.

1 reference

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25 September 2018

Overexpression of epidermal growth factor receptor in urothelium elicits urothelial hyperplasia and promotes bladder tumor growth.

1 reference

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25 September 2018

Regulation of the G2/M transition by p53.

1 reference

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25 September 2018

Urothelial dysplasia of the bladder: diagnostic features and clinical significance

1 reference

https://pubmed.ncbi.nlm.nih.gov/25795707

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allelic loss of p53 gene is associated with genesis and maintenance, but not invasion, of mouse carcinoma in situ of the bladder

1 reference

https://pubmed.ncbi.nlm.nih.gov/25795707

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic alterations in bladder cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25795707

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene deletion in urothelium by specific expression of Cre recombinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25795707

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-14-3067

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25795707%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25795707%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25795707%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

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